全部 |
  • 全部
  • 题名
  • 关键词
  • NSTL主题词
  • 摘要
  • 论文-出处
  • 论文-作者
  • 论文-机构
  • 论文-DOI
  • 期刊-出版者
  • 期刊-出版地
  • 期刊-主编
  • ISSN
  • EISSN
  • ISBN
  • EISBN
检索 搜索期刊 二次检索 AI检索
外文文献 中文文献
筛选条件:

2. Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis NSTL国家科技图书文献中心

Nightingale, Rebecca |  Reehorst, Camilla M.... -  《Developmental cell》 - 2024,59(15) - 共29页

摘要:The transcription factor EHF is highly |  expressed in the lactating mammary gland, but its role in |  mammary development and tumorigenesis is not fully |  understood. Utilizing a mouse model of Ehf deletion, herein | , we demonstrate that loss of Ehf impairs mammary
关键词: LUMINAL CELL-FATE |  GLAND DEVELOPMENT |  TRANSCRIPTION FACTORS |  DUCTAL MORPHOGENESIS |  EXPRESSION ANALYSIS |  GENE DELETION |  STEM-CELLS |  ETS FAMILY |  REVEALS |  ELF5

3. Dividing out quantification uncertainty allows efficient assessment of differential transcript expression with edgeR NSTL国家科技图书文献中心

Baldoni, Pedro L. |  Chen, Yunshun... -  《Nucleic Acids Research》 - 2024,52(3) - 共13页 - 被引量:1

摘要:Differential expression analysis of RNA-seq is |  one of the most commonly performed bioinformatics |  analyses. Transcript-level quantifications are inherently |  more uncertain than gene-level read counts because of |  ambiguous assignment of sequence reads to transcripts
关键词: RNA-SEQ

4. Radiolabelling and preclinical characterisation of [ 89 Zr]Zr-Df-ATG-101 bispecific to PD-L1/4-1BB NSTL国家科技图书文献中心

Cao, Zhipeng |  Wichmann, Christian ...... -  《European Journal of Nuclear Medicine and Molecular Imaging》 - 2024,51(11) - 3202~3214 - 共13页 - 被引量:2

摘要:Purpose ATG-101, a bispecific antibody that |  simultaneously targets the immune checkpoint PD-L1 and the |  costimulatory receptor 4-1BB, activates exhausted T cells upon |  PD-L1 crosslinking. Previous studies demonstrated |  promising anti-tumour efficacy of ATG-101 in preclinical
关键词: PD-L1 |  4-1BB |  ATG-101 |  PET |  Zirconium-89 |  UPTAKE RATIO SUR |  IMMUNE CHECKPOINT |  PD-L1 EXPRESSION |  MONOCLONAL-ANTIBODIES |  COMBINED NIVOLUMAB...

5. Targeting Fn14 as a therapeutic target for cachexia reprograms the glycolytic pathway in tumour and brain in mice NSTL国家科技图书文献中心

Burvenich, Ingrid Ju... |  Osellame, Laura Dani...... -  《European Journal of Nuclear Medicine and Molecular Imaging》 - 2024,51(13) - 3854~3862 - 共9页

摘要:Purpose Cachexia is a complex syndrome |  characterized by unintentional weight loss, progressive muscle |  wasting and loss of appetite. Anti-Fn14 antibody (mAb |  002) targets the TWEAK receptor (Fn14) in murine |  models of cancer cachexia and can extend the lifespan
关键词: Fn14 receptor |  TWEAK |  [F-18]FDG PET |  Cancer cachexia |  002 antibody |  CANCER |  METABOLISM |  WEIGHT

6. Targeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with 89 Zr-labelled CI-8993 NSTL国家科技图书文献中心

Burvenich, Ingrid Ju... |  Wichmann, Christian ...... -  《European Journal of Nuclear Medicine and Molecular Imaging》 - 2024,51(13) - 3863~3873 - 共11页

摘要:Background CI-8993 is a fully human IgG1 kappa |  monoclonal antibody (mAb) that binds specifically to immune |  checkpoint molecule VISTA (V-domain Ig suppressor of T-cell |  activation). Phase I safety has been established in |  patients with advanced cancer (NCT02671955). To determine
关键词: CI-8993 |  VISTA |  Zirconium-89 |  Theranostic |  Immune checkpoint |  PET |  ANTIBODY

7. Making recommendations to subsidize new health technologies in Australia: A qualitative study of decision-makers' perspectives on committee processes NSTL国家科技图书文献中心

Sellars, Marcus |  Carter, Stacy M.... -  《Health policy》 - 2024,139 - 104963~104963 - 共6页 - 被引量:1

摘要:Objectives: To explore experiences of, and |  perspectives on, health technology assessment (HTA) processes |  used to produce recommendations about subsidizing new |  medicines, and medical technologies in Australia, from the |  perspectives of those experienced in these processes. Methods
关键词: Health technology assessment |  Decision -making process |  Equity |  MSAC |  PBAC |  Semi -structured interviews |  Australia |  FUNDING DECISIONS |  ENGAGEMENT |  CRITERIA...

8. Activation of Ca 2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies NSTL国家科技图书文献中心

Marchesan, Elena |  Nardin, Alice... -  《Cell death and differentiation》 - 2024,31(2) - 217~238 - 共22页 - 被引量:2

摘要:Selective removal of dysfunctional |  mitochondria via autophagy is crucial for the maintenance of |  cellular homeostasis. This event is initiated by the |  translocation of the E3 ubiquitin ligase Parkin to damaged |  mitochondria, and it requires the Serine/Threonine-protein
关键词: E3 LIGASE PARKIN |  PINK1/PARKIN-MEDIATED MITOPHAGY |  DAMAGED MITOCHONDRIA |  QUALITY-CONTROL |  MITOFUSIN 2 |  PINK1 |  UBIQUITIN |  PROTEIN |  DISEASE |  MUTATIONS

9. Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism NSTL国家科技图书文献中心

Torres, Santiago Val... |  Man, Kevin... -  《Nature immunology》 - 2024,25(3) - 共39页 - 被引量:16

摘要:Visceral adipose tissue (VAT) is an energy |  store and endocrine organ critical for metabolic |  homeostasis. Regulatory T (Treg) cells restrain inflammation |  to preserve VAT homeostasis and glucose tolerance | . Here, we show that the VAT harbors two distinct Treg
关键词: PPAR-GAMMA |  REG CELLS |  INFLAMMATION |  IL-33 |  GENE |  BET |  EXPRESSION |  RECEPTOR |  FAT |  ACCUMULATION

10. Targeting Molecular Measurable Residual Disease and Low-Blast Relapse in AML With Venetoclax and Low-Dose Cytarabine: A Prospective Phase II Study (VALDAC) NSTL国家科技图书文献中心

Tiong, Ing Soo |  Hiwase, Devendra K.... -  《Journal of clinical oncology》 - 2024,42(18) - 2161~2173 - 共13页

摘要:PURPOSEA prospective phase II study examined |  the safety and efficacy of venetoclax combined with |  low-dose cytarabine (LDAC) in AML at first |  measurable residual disease (MRD) or oligoblastic |  relapse.METHODSPatients with either MRD (>= 1 log10 rise) or
关键词: ACUTE MYELOID-LEUKEMIA |  HEMATOPOIETIC-CELL TRANSPLANTATION |  ADULTS |  MRD
检索条件机构:Olivia Newton John Canc Res Inst
  • 检索词扩展

NSTL主题词

  • NSTL学科导航