Wielenberg, Kevin. -  Chemistry.;Biochemis... -  Ph.D. -  Lin, Hening - 2022, - 1～150 - 共150页

摘要：My graduate research focuses on the |  development of small molecule probes or inhibitors that can |  be used in diverse sets of applications. In chapter |  1, I present a new biochemical probe called AP3B |  that crosslinks and biotinylates nucleic acids. The

关键词： Protein deacylation |  Cancer |  Colitis |  Nucleic acid |  Protein crosslinkers

Karim, Rezwana. -  Cornell University. -  Biochemistry.;Cellul... -  Ph.D. -  Lin, Hening - 2024, - 1～107 - 共108页

摘要：Mammalian cells possess intricate mechanisms |  to adapt to malnutrition and starvation, with de |  novo lipogenesis (DNL) emerging as a pivotal pathway |  during stress. This thesis explores the regulation of |  lipid metabolism under nutrient stress, focusing on

Latifkar, Arash. -  Cornell University. -  Biochemistry.;Biolog... -  Ph.D. -  Cerione, Richard |  Lin, Hening - 2020, - 1～202 - 共203页

摘要：Spread of tumor cells from their primary sites |  to vital distant organs and tissues, i.e.metastasis | , is the most devastating stage of cancer development | . Metastatic tumors grow rapidly, and they rarely respond to |  therapeutic interventions. Thus, a better understanding of

Jing, Hui. -  Cornell University. -  Chemistry.;Biochemis... -  Ph.D. -  Lin, Hening - 2017, - 共159页

摘要：SIRT2 belongs to the mammalian sirtuin or NAD | -dependent lysine deacylase family. Growing evidence |  suggests that SIRT2 plays important roles in cell cycle |  regulation, stress response, metabolism and differentiation |  by deacetylating a wide variety of substrates

Zhang, Xiaoyu. -  Cornell University. -  Cellular biology.;Ch... -  Ph.D. -  Lin, Hening - 2017, - 共166页

摘要：Sir2 (silencing information regulator 2 | ) family of enzymes (or sirtuins) are nicotinamide |  adenine dinucleotide (NAD+)-dependent protein lysine |  deacylases and play a variety of roles in biological |  systems. SIRT6 is one of the seven mammalian sirtuins

Aramsangtienchai, Po... -  Cornell University. -  Molecular biology.;G... -  Ph.D. -  Lin, Hening - 2016, - 共162页

摘要：S-palmitoylation has been implicated in |  numerous biological processes. Due to advances in |  proteomic technologies, the number of S-palmitoylated |  proteins has markedly increased. However, not all of the |  identified S-palmitoylated proteins have been well