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1. Early life adversity as a risk factor for cognitive impairment and Alzheimer's disease

Huang, Zhihai |  Jordan, J. Dedrick... -  《translational neurodegeneration》 - 2023,12(1) - 共18页

摘要:Neurological conditions, including |  cognitive impairment and Alzheimer's disease (AD), impose |  a huge burden on society, affecting millions of |  people globally. In addition to genetic factors, recent |  studies indicate that environmental and experiential
关键词: Early life adversity |  Cognitive impairment |  Alzheimer's disease |  Dementia |  Stress |  ADULT HIPPOCAMPAL NEUROGENESIS |  LONG-LASTING CONSEQUENCES |  PITUITARY-ADRENAL AXIS |  MATERNAL SEPARATION |  MOUSE MODEL...

2. Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges

Zhu, Longhong |  Li, Shihua... -  《translational neurodegeneration》 - 2023,12(1) - 共16页

摘要:In order to dissect amyotrophic lateral |  sclerosis (ALS), a multigenic, multifactorial, and |  progressive neurodegenerative disease with heterogeneous |  clinical presentations, researchers have generated |  numerous animal models to mimic the genetic defects
关键词: Amyotrophic lateral sclerosis |  Animal model |  Rodent |  Non-human primate |  CANINE DEGENERATIVE MYELOPATHY |  MOTOR-NEURON DEGENERATION |  SUPEROXIDE-DISMUTASE 1 |  HEXANUCLEOTIDE REPEAT EXPANSIONS |  TRANSGENIC RAT MODEL |  RNA-BINDING PROTEINS...

3. Head-to-head comparison of plasma and PET imaging ATN markers in subjects with cognitive complaints

Lu, Jiaying |  Ma, Xiaoxi... -  《translational neurodegeneration》 - 2023,12(1) - 共15页

摘要:BackgroundGaining more information about the |  reciprocal associations between different biomarkers within |  the ATN (Amyloid/Tau/Neurodegeneration) framework |  across the Alzheimer's disease (AD) spectrum is |  clinically relevant. We aimed to conduct a comprehensive
关键词: ATN biomarkers |  PET imaging |  Plasma |  Clinical severity |  PHOSPHORYLATED TAU 181 |  ALZHEIMERS-DISEASE |  CLINICAL-DIAGNOSIS |  AMYLOID PET |  PERFORMANCE |  IMPAIRMENT...

4. Seed amplification assay of nasal swab extracts for accurate and non-invasive molecular diagnosis of neurodegenerative diseases

Duan, Suying |  Yang, Jing... -  《translational neurodegeneration》 - 2023,12(1) - 共10页

摘要:Nasal swabs are non-invasive testing methods |  for detecting diseases by collecting samples from |  the nasal cavity or nasopharynx. Dysosmia is |  regarded as an early sign of coronavirus disease 2019 |  (COVID-19), and nasal swabs are the gold standard for
关键词: Nasal swab |  Seed amplification assay |  Prion disease |  Amyloid |  Neurodegenerative diseases |  QUAKING-INDUCED CONVERSION |  CREUTZFELDT-JAKOB-DISEASE |  SLEEP BEHAVIOR DISORDER |  HUMAN PRION DETECTION |  OLFACTORY-BULB...

5. Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model

Tallon, Carolyn |  Bell, Benjamin J.... -  《translational neurodegeneration》 - 2023,12(1) - 共20页

摘要:BackgroundCognitive decline in Alzheimer's |  disease (AD) is associated with hyperphosphorylated tau |  (pTau) propagation between neurons along synaptically |  connected networks, in part via extracellular vesicles |  (EVs). EV biogenesis is triggered by ceramide
关键词: Alzheimer's disease |  Extracellular vesicles |  Neutral sphingomyelinase 2 |  Tau |  Ceramide |  EXTRACELLULAR VESICLES |  CEREBROSPINAL-FLUID |  COGNITIVE DECLINE |  PLASMA CERAMIDES |  SYNAPSE LOSS...

6. Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis

Richardson, Peter J. |  Smith, Daniel P.... -  《translational neurodegeneration》 - 2023,12(1) - 共17页

摘要:Amyotrophic lateral sclerosis (ALS) is a |  poorly treated multifactorial neurodegenerative disease |  associated with multiple cell types and subcellular |  organelles. As with other multifactorial diseases, it is |  likely that drugs will need to target multiple disease
关键词: Janus kinase |  STAT3 |  Amyotrophic lateral sclerosis |  MITOCHONDRIAL-DNA RELEASE |  SKELETAL-MUSCLE |  MOUSE MODEL |  MOTOR-NEURONS |  SPINAL-CORD |  SELECTIVE VULNERABILITY |  MOLECULAR-MECHANISMS...

7. Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis

de Dios, Cristina |  Abadin, Xenia... -  《translational neurodegeneration》 - 2023,12(1) - 共23页

摘要:BackgroundPersistent inflammatory response in |  the brain can lead to tissue damage and |  neurodegeneration. In Alzheimer's disease (AD), there is an |  aberrant activation of inflammasomes, molecular platforms |  that drive inflammation through caspase-1-mediated
关键词: Neuroinflammation |  Mitochondrial oxidative stress |  Phagocytosis |  Alzheimer's disease |  DAM signature |  NLRP3 |  ALZHEIMERS-DISEASE |  AMYLOID-BETA |  A-BETA |  INTERLEUKIN-1-BETA...

8. Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer's disease

Arroyo-Garcia, Luis ... |  Bachiller, Sara... -  《translational neurodegeneration》 - 2023,12(1) - 共23页

摘要:BackgroundAlzheimer's disease (AD) is a |  progressive multifaceted neurodegenerative disorder for |  which no disease-modifying treatment exists | . Neuroinflammation is central to the pathology progression, with |  evidence suggesting that microglia-released galectin-3
关键词: Galectin-3 |  Gamma oscillations |  Neuronal network dynamics |  Fast-spiking interneurons |  Alzheimer's disease models |  Neuroinflammation |  TD139 |  Hippocampus |  AMYLOID-BETA |  MOUSE MODEL...

9. Research progress on the role of extracellular vesicles in neurodegenerative diseases

Li, Zhengzhe |  Wang, Xiaoling... -  《translational neurodegeneration》 - 2023,12(1) - 共19页

摘要:Neurodegenerative diseases, such as |  Alzheimer's disease, Parkinson's disease, amyotrophic |  lateral sclerosis, and Huntington's disease, affect |  millions of people worldwide. Tremendous efforts have |  been put into disease-related research, but few
关键词: Extracellular vesicle |  Neurodegenerative disease |  Central nervous system |  Neurodegeneration |  Pathogenesis |  Biomarker |  AMYOTROPHIC-LATERAL-SCLEROSIS |  DIPEPTIDE-REPEAT PROTEINS |  ALZHEIMERS-DISEASE |  ALPHA-SYNUCLEIN...

10. Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases

Shadfar, Sina |  Parakh, Sonam... -  《translational neurodegeneration》 - 2023,12(1) - 共34页

摘要:Redox homeostasis refers to the balance |  between the production of reactive oxygen species (ROS | ) as well as reactive nitrogen species (RNS), and |  their elimination by antioxidants. It is linked to all |  important cellular activities and oxidative stress is a
关键词: Redox dysregulation |  DNA damage |  Neurodegeneration |  Reactive oxygen species |  Oxidative stress |  AMYOTROPHIC-LATERAL-SCLEROSIS |  BASE-EXCISION-REPAIR |  PROTEIN DISULFIDE-ISOMERASE |  POLYCYCLIC AROMATIC-HYDROCARBONS |  SINGLE-NUCLEOTIDE POLYMORPHISMS...
检索条件出处:translational neurodegeneration
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