NSTL国家科技图书文献中心

1. Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir

Briganti, Lorenzo | Annamalai, Arun S.... - 《MBio》 - 2025,16(5) - 共22页

摘要：Lenacapavir (LEN) is the first-in-class viral | capsid protein (CA) targeting antiretroviral for | treating multi-drug-resistant HIV-1 infection. Clinical | trials and cell culture experiments have identified | resistance-associated mutations (RAMs) in the vicinity of

关键词： HIV-1 | antiretroviral agents | capsid | drug resistance | structure | HUMAN-IMMUNODEFICIENCY-VIRUS | RECOGNITION | HIV | INTEGRATION | INHIBITOR...

2. The AusAB non-ribosomal peptide synthetase of Staphylococcus aureus preferentially generates phevalin in host-mimicking media

Moldovan, Adriana | Krischke, Markus ... - 《MBio》 - 2025, - 共8页

摘要：Non-ribosomal peptide synthetases (NRPSs) are | modular multidomain enzymes responsible for the | biosynthesis of various secondary metabolites in an mRNA | template-independent manner. They are predominantly | present in bacteria and fungi, where they synthesize a

关键词： Staphylococcus aureus | non-ribosomal peptide synthetases | aureusimines | phevalin | tyrvalin | EXPRESSION

3. Dual oxic-anoxic co-culture enables direct study of anaerobe-host interactions at the airway epithelial interface

Moore, Patrick J. | Hoffman, Kayla ... - 《MBio》 - 2025,16(5) - 共22页

摘要：Strict and facultative anaerobic bacteria are | widely associated with both acute and chronic airway | diseases. However, their potential role(s) in disease | pathophysiology remains poorly understood due to inherent | limitations of existing laboratory models and conflicting

关键词： Fusobacterium nucleatum | airway epithelium | RNAseq | single-cell RNA sequencing | CHAIN FATTY-ACIDS | FUSOBACTERIUM-NUCLEATUM | PSEUDOMONAS-AERUGINOSA | PREVOTELLA-INTERMEDIA | BINDING-PROTEIN | ORAL BACTERIA...

4. Immunotherapy with nebulized pattern recognition receptor agonists restores severe immune paralysis and improves outcomes in mice with influenza-associated pulmonary aspergillosis

Garcia, Jezreel Pant... | Wurster, Sebastian ... - 《MBio》 - 2025,16(5) - 共18页

摘要：Influenza-associated pulmonary aspergillosis | (IAPA) is a potentially deadly superinfection in | patients with influenza pneumonia, especially those with | severe disease, underlying immunosuppression | , corticosteroid therapy, or requiring intensive care support

关键词： pneumonia | influenza | aspergillosis | immunotherapy | immunomodulation | cytokines | macrophages | epithelial pathogenesis | animal models | innate immunity recognition...

5. Naturally occurring influenza reassortment in pigs facilitates the emergence of intrahost virus subpopulations with distinct genotypes and replicative fitness

Li, Chong | Meliopoulos, Victori...... - 《MBio》 - 2025,16(1) - 共16页

摘要：Pigs are recognized as amplifying hosts for | influenza A virus (IAV) reassortant viruses. Understanding | the extent of IAV reassortment occurring at the | individual pig level in naturally infected pigs and how | reassortment impacts virus diversity, persistence, and

关键词： influenza A virus | reassortment | replicative fitness | pig | swine farm | RESPIRATORY-TRACT | HUMAN INFECTION | A(H1N1) VIRUS | A VIRUSES | SWINE...

6. Reduced prevalence of phage defense systems in Pseudomonas aeruginosa strains from cystic fibrosis patients

van den Berg, Daan F... | Brouns, Stan J. J. - 《MBio》 - 2025, - 共5页

摘要：Cystic fibrosis is a genetic disorder that | affects mucus clearance, particularly of the lungs. As a | result, cystic fibrosis patients often experience | infections from bacteria, which contribute to the disease | progression. Pseudomonas aeruginosa is one of the most

关键词： phage defense systems | Pseudomonas aeruginosa | cystic fibrosis | phage therapy | mucus | Zorya | CRISPR-Cas | Wadjet | plasmid-restrictive mechanisms

7. 3D meshwork architecture of the outer coat protein CotE: implications for bacterial endospore sporulation and germination

Lee, Dukwon | Baek, Yeongjin ... - 《MBio》 - 2025, - 共20页

摘要：Bacillus cereus, a Gram-positive aerobic | bacterium commonly found in soil, food, and water, forms | endospores that can withstand harsh environmental | conditions. The endospores are encased in a protective | spore coat consisting of multiple layers of proteins

关键词： CotE | endospore | Bacillus cereus | cryo-electron microscopy | cryo-electron tomography | BACILLUS-SUBTILIS | DIPICOLINIC ACID | SPORE GERMINATION | ALGORITHMS | GROMACS

8. The Rickettsia actin-based motility effectors RickA and Sca2 contribute differently to cell-to-cell spread and pathogenicity

Tran, Cuong J. | Zubair-Nizami, Zahra ... - 《MBio》 - 2025,16(2) - 共20页

摘要：Rickettsia parkeri is an obligate | intracellular, tick-borne bacterial pathogen that can cause | eschar-associated rickettsiosis in humans. R. parkeri | invades host cells, escapes from vacuoles into the | cytosol, and undergoes two independent modes of actin

关键词： Rickettsia | cell biology | actin-based motility | cell-to-cell spread | animal models | SHIGELLA-FLEXNERI DISSEMINATION | LISTERIA-MONOCYTOGENES | ARP2/3 COMPLEX | INTERCELLULAR SPREAD | PROTRUSION FORMATION...

9. The Mla pathway promotes Vibrio cholerae re-expansion from stationary phase

Leitner, Deborah R. | Zingl, Franz G.... - 《MBio》 - 2025,16(2) - 共17页

摘要：Bacteria have evolved diverse strategies to | ensure survival under nutrient-limited conditions | , where rapid energy generation is not achievable. Here | , we performed a transposon insertion site sequencing | loss-of-function screen to identify Vibrio cholerae

关键词： Vibrio cholerae | maintenance of lipid asymmetry | stationary phase | culturability | ESCHERICHIA-COLI | SURVIVAL | GROWTH

10. Signaling pathways governing the pathobiological features and antifungal drug resistance of Candida auris

Cha, Hyunjin | Won, Doyeon ... - 《MBio》 - 2025,16(5) - 共14页

摘要：Candida auris is an emerging multidrug | -resistant fungal pathogen that poses a significant global | health threat. Since its discovery in 2009, C. auris | has rapidly spread worldwide, causing severe | infections with high mortality rates, particularly in

关键词： C. auris | signaling pathways | virulence | antifungal drug resistance | candidiasis | UNITED-STATES | VIRULENCE | SUSCEPTIBILITY | CALCINEURIN | EMERGENCE...

摘要：Lenacapavir (LEN) is the first-in-class viral | capsid protein (CA) targeting antiretroviral for | treating multi-drug-resistant HIV-1 infection. Clinical | trials and cell culture experiments have identified | resistance-associated mutations (RAMs) in the vicinity of

关键词： HIV-1 | antiretroviral agents | capsid | drug resistance | structure | HUMAN-IMMUNODEFICIENCY-VIRUS | RECOGNITION | HIV | INTEGRATION | INHIBITOR...

摘要：Non-ribosomal peptide synthetases (NRPSs) are | modular multidomain enzymes responsible for the | biosynthesis of various secondary metabolites in an mRNA | template-independent manner. They are predominantly | present in bacteria and fungi, where they synthesize a

关键词： Staphylococcus aureus | non-ribosomal peptide synthetases | aureusimines | phevalin | tyrvalin | EXPRESSION

摘要：Strict and facultative anaerobic bacteria are | widely associated with both acute and chronic airway | diseases. However, their potential role(s) in disease | pathophysiology remains poorly understood due to inherent | limitations of existing laboratory models and conflicting

关键词： Fusobacterium nucleatum | airway epithelium | RNAseq | single-cell RNA sequencing | CHAIN FATTY-ACIDS | FUSOBACTERIUM-NUCLEATUM | PSEUDOMONAS-AERUGINOSA | PREVOTELLA-INTERMEDIA | BINDING-PROTEIN | ORAL BACTERIA...

摘要：Influenza-associated pulmonary aspergillosis | (IAPA) is a potentially deadly superinfection in | patients with influenza pneumonia, especially those with | severe disease, underlying immunosuppression | , corticosteroid therapy, or requiring intensive care support

关键词： pneumonia | influenza | aspergillosis | immunotherapy | immunomodulation | cytokines | macrophages | epithelial pathogenesis | animal models | innate immunity recognition...

摘要：Pigs are recognized as amplifying hosts for | influenza A virus (IAV) reassortant viruses. Understanding | the extent of IAV reassortment occurring at the | individual pig level in naturally infected pigs and how | reassortment impacts virus diversity, persistence, and

关键词： influenza A virus | reassortment | replicative fitness | pig | swine farm | RESPIRATORY-TRACT | HUMAN INFECTION | A(H1N1) VIRUS | A VIRUSES | SWINE...

摘要：Cystic fibrosis is a genetic disorder that | affects mucus clearance, particularly of the lungs. As a | result, cystic fibrosis patients often experience | infections from bacteria, which contribute to the disease | progression. Pseudomonas aeruginosa is one of the most

关键词： phage defense systems | Pseudomonas aeruginosa | cystic fibrosis | phage therapy | mucus | Zorya | CRISPR-Cas | Wadjet | plasmid-restrictive mechanisms

摘要：Bacillus cereus, a Gram-positive aerobic | bacterium commonly found in soil, food, and water, forms | endospores that can withstand harsh environmental | conditions. The endospores are encased in a protective | spore coat consisting of multiple layers of proteins

关键词： CotE | endospore | Bacillus cereus | cryo-electron microscopy | cryo-electron tomography | BACILLUS-SUBTILIS | DIPICOLINIC ACID | SPORE GERMINATION | ALGORITHMS | GROMACS

摘要：Rickettsia parkeri is an obligate | intracellular, tick-borne bacterial pathogen that can cause | eschar-associated rickettsiosis in humans. R. parkeri | invades host cells, escapes from vacuoles into the | cytosol, and undergoes two independent modes of actin

关键词： Rickettsia | cell biology | actin-based motility | cell-to-cell spread | animal models | SHIGELLA-FLEXNERI DISSEMINATION | LISTERIA-MONOCYTOGENES | ARP2/3 COMPLEX | INTERCELLULAR SPREAD | PROTRUSION FORMATION...

摘要：Bacteria have evolved diverse strategies to | ensure survival under nutrient-limited conditions | , where rapid energy generation is not achievable. Here | , we performed a transposon insertion site sequencing | loss-of-function screen to identify Vibrio cholerae

关键词： Vibrio cholerae | maintenance of lipid asymmetry | stationary phase | culturability | ESCHERICHIA-COLI | SURVIVAL | GROWTH

摘要：Candida auris is an emerging multidrug | -resistant fungal pathogen that poses a significant global | health threat. Since its discovery in 2009, C. auris | has rapidly spread worldwide, causing severe | infections with high mortality rates, particularly in

关键词： C. auris | signaling pathways | virulence | antifungal drug resistance | candidiasis | UNITED-STATES | VIRULENCE | SUSCEPTIBILITY | CALCINEURIN | EMERGENCE...

4008-161-200 800-990-8900

国家科技图书文献中心