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1. Impacts of heatwaves on electricity reliability: Evidence from power outage data in China

Liang, Jing |  Qiu, Yueming (Lucy)... -  《iscience》 - 2025,28(2) - 共15页

摘要：Heatwaves, driven by climate change, have |  increasingly challenged energy systems with increased demand |  and reduced supply, leading to power outages. This |  study empirically examines the impact of heatwaves on |  power outages, employing fixed-effects models and
关键词： AIR-POLLUTION |  CLIMATE |  TEMPERATURE |  WEATHER |  MORTALITY |  EXTREMES |  HEALTH |  LEARN
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2. Mapping the chromothripsis landscape in urothelial carcinoma unravels great intratumoral and inter tumoral heterogeneity

Zeng, Yuchen |  Lv, Wei... -  《iscience》 - 2025,28(1) - 共15页

摘要：Chromothripsis, a hallmark of cancer, is |  characterized by extensive and localized DNA rearrangements |  involving one or a few chromosomes. However, its genome | -wide frequency and characteristics in urothelial |  carcinoma (UC) remain largely unknown. Here, by analyzing
关键词： CANCER |  REARRANGEMENT |  DNA
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3. Assessing the impacts of coal-to-electricity transition in China's regional power system and "2

Zhu, Lei |  Liang, Zhuang... -  《iscience》 - 2025,28(2) - 共17页

摘要：Compared to air pollution, the Coal to |  Electricity (CtE) policy's impacts on the power system are |  less discussed. As China transitions to carbon |  neutrality, unstable wind, and photovoltaic (PV) units |  exacerbate power dispatching challenges amid increased
关键词： Highlights |  pressure |  heating |  BUILDING ENERGY EFFICIENCY |  MODEL
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4. TRIM47 promotes head and neck squamous cell carcinoma malignant progression by degrading XAF1 through ubiquitination

Yu, Changyun |  Zhang, Chen... -  《iscience》 - 2025,28(1) - 共20页

摘要：Tripartite motif-containing 47 (TRIM47) is a |  member of the TRIM family, which has E3 ligase activity |  and has been demonstrated to be involved in tumor |  development. In this work, we found that TRIM47 is highly |  expressed in head and neck squamous cell carcinomas (HNSCC
关键词： AUTOPHAGY |  PROTEINS |  DISEASE
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5. Application of nanomaterials in precision treatment of lung cancer

Zhang, Chengcheng |  Fan, Jiang... -  《iscience》 - 2025,28(1) - 共13页

摘要：Lung cancer remains one of the most prevalent |  and lethal malignancies worldwide, characterized by |  high mortality rates due to its aggressive nature | , metastatic potential, and drug resistance. Despite |  advancements in conventional therapies, their efficacy is
关键词： PHOTODYNAMIC THERAPY |  GOLD NANOPARTICLES |  DELIVERY |  CHEMOTHERAPY |  RESISTANCE |  NANOMEDICINE |  DOXORUBICIN |  MECHANISMS |  PACLITAXEL |  CISPLATIN
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6. Origin and development of uniparental and polyploid blastomeres

Zhao, Yan |  Fernandez-Montoro, A...... -  《iscience》 - 2025,28(5) - 共19页

摘要：Whole-genome (WG) abnormalities, such as |  uniparental diploidy and triploidy, cause fetal death | . Occasionally, they coexist with biparental diploid cells in |  live births. Understanding the origin and early |  development of WG abnormal blastomeres is crucial for
关键词： GENE-EXPRESSION |  PREIMPLANTATION DEVELOPMENT |  BOVINE EMBRYOS |  CELLS |  STAGE |  RNA |  IMPLANTATION |  ACTIVATION |  BLASTOCYST |  CHIMERISM
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7. Mixed-method analysis of published national one health strategic plans

Wilhelm, Caroline S. |  Desvars-Larrive, Ame...... -  《iscience》 - 2025,28(2) - 共21页

摘要：In this article, we used a mixed analytical |  framework to assess existing National One Health Strategic |  Plans (NOHSPs) and evaluate their alignment with |  recognized One Health principles. Eight NOHSPs were |  examined following a qualitative content analysis and key
关键词： POLICY-ANALYSIS |  AGENDA |  TOOL
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8. Parallel tempered Bayesian inference for characterizing non-ideal semiconductors: Carrier trapping in cadmium telluride thin films

Fai, Calvin |  Ladd, Anthony J. C.... -  《iscience》 - 2025,28(2) - 共16页

摘要：We describe an improved Bayesian inference |  methodology to characterize photovoltaic materials by |  matching charge carrier simulations to spectroscopy data | . A "parallel tempering"scheme is introduced, which |  efficiently and reliably locates the global maximum in the
关键词： MINORITY
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9. Article UFMylation maintains YAP stability to promote vascular endothelial cell senescence

Liu, Yanan |  Zuo, Min... -  《iscience》 - 2025,28(2) - 共17页

摘要：Endothelial cell (EC) senescence is an |  accomplice for vascular aging, which leads to |  cardiovascular diseases (CVDs). Evidences showed that Hippo-Yes | -associated protein (YAP) signaling pathway plays an |  essential role in aging-associated CVDs. Here, we reported
关键词： ORGAN SIZE CONTROL |  HIPPO PATHWAY |  REGENERATION |  DYSFUNCTION |  MECHANISMS |  DELETION
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10. Modeling autoregulation of cardiac excitation-Ca-contraction and arrhythmogenic activities in response to mechanical load changes

Hatano, Asuka |  Izu, Leighton T.... -  《iscience》 - 2025,28(2) - 共16页

摘要：The heart has intrinsic abilities to |  autoregulate contractile force in response to mechanical load | . Recent experimental studies show that cardiomyocytes |  have mechano-chemo-transduction (MCT) mechanisms that |  form a closed feedback loop in the excitation-Ca2
关键词： ACTION-POTENTIAL REPOLARIZATION |  EARLY AFTERDEPOLARIZATIONS |  CHEMO-TRANSDUCTION |  ION CHANNELS |  NITRIC-OXIDE |  QT INTERVAL |  PIG HEARTS |  STRETCH |  ALTERNANS |  DYNAMICS
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