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1. Spatial gene regulatory networks driving cell state transitions during human liver disease

Hammond, Nigel L. |  Baker, Syed Murtuza... -  《embo molecular medicine》 - 2025, - 共23页

摘要：Liver fibrosis is a major cause of death |  worldwide. As a progressive step in chronic liver disease | , fibrosis is almost always diagnosed too late with limited |  treatment options. Here, we uncover the spatial |  transcriptional landscape driving human liver fibrosis using
关键词： Liver Fibrosis |  Spatial Transcriptomics |  scRNAseq |  scATACseq |  Cell State |  EXPRESSION |  PROLIFERATION |  HEPATOCYTE |  SOX9 |  REGENERATION...
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2. Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression

Lee, Sang-Hoon |  Kim, Hyun-Jun... -  《embo molecular medicine》 - 2025, - 共30页

摘要：Skeletal muscle wasting results from numerous |  conditions, such as sarcopenia, glucocorticoid therapy or |  intensive care. It prevents independent living in the |  elderly, predisposes to secondary diseases, and |  ultimately reduces lifespan. There is no approved drug
关键词： Skeletal Muscle Wasting |  DUSP22 |  Myofiber Atrophy |  FOXO3a |  BML-260 |  JNK |  RHODANINE |  INHIBITORS |  PATHWAY |  DRUGS...
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3. Improving the odds of survival: transgenerational effects of infections

Spanou, Victoria M. |  Andriopoulou, Theano...... -  《embo molecular medicine》 - 2025,17(4) - 609～624 - 共16页

摘要：Recent studies argue for a novel concept of |  the role of chromatin as a carrier of epigenetic |  memory through cellular and organismal generations | , defining and coordinating gene activity states and |  physiological functions. Environmental insults, such as
关键词： Epigenetic Memory |  Epigenetics |  Evolution |  Infections |  Transgenerational Epigenetic Inheritance |  RED FLOUR BEETLE |  MATERNAL TRANSFER |  CHROMATIN STATES |  MEALWORM BEETLE |  INFLUENZA...
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4. Targeting FKBP51 prevents stress-induced preterm birth

Guzeloglu-Kayisli, O... |  Ozmen, Asli... -  《embo molecular medicine》 - 2025,17(4) - 775～796 - 共22页

摘要：Preterm birth (PTB) is a leading cause of |  perinatal morbidity and mortality, with maternal stress | -related disorders, such as depression and anxiety | , linked to idiopathic PTB (iPTB). At the maternal-fetal |  interface, decidualized stromal cells (DSCs) exclusively
关键词： 15dPGJ2 |  Maternal Stress |  Preterm Birth |  FKBP51 |  Progesterone Receptor |  FUNCTIONAL PROGESTERONE WITHDRAWAL |  FACTOR-KAPPA-B |  DOUBLE-BLIND |  RECEPTOR EXPRESSION |  CO-CHAPERONE...
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5. Predictive modeling of glioblastoma recurrence for therapeutic target identification

Miletic, Hrvoje |  Daubon, Thomas -  《embo molecular medicine》 - 2025, - 共3页

摘要：Patient-derived xenograft (PDX) models are an |  essential resource in cancer research, enabling the |  discovery of novel molecular mechanisms and therapeutic |  targets, while providing a preclinical platform for the |  evaluation of experimental treatments. For glioblastoma (GB
关键词： TUMORS
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6. PARP7 as a new target for activating anti-tumor immunity in cancer

Popova, Katerina |  Benedum, Johannes... -  《embo molecular medicine》 - 2025, - 共17页

摘要：ADP-ribosyl transferases (ARTs) are a family |  of enzymes which catalyze the addition of a chain |  (PARylation) or a single moiety (MARylation) of ADP-ribose |  to their substrates. PARP7 is a mono-ADP-ribosyl |  transferase (mono-ART) which has recently gained attention
关键词： PARP7 |  ADP-ribosylation |  Type I Interferon Response |  Anti-tumor Immunity |  Nuclear Receptors |  ADP-RIBOSE POLYMERASE |  TIPARP |  SITE |  RIBOSYLATION |  INHIBITION...
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7. Soluble CD27 differentially predicts resistance to anti-PD1 alone but not with anti-CTLA-4 in melanoma

Sam, Ikuan |  Benhamouda, Nadine... -  《embo molecular medicine》 - 2025, - 共14页

摘要：Metastatic melanoma can be treated with anti | -PD-1 monotherapy or in combination with anti-CTLA-4 |  or anti-Lag3. However, combination therapy is |  associated with a high risk of toxicity. Recently, we |  reported that high plasma soluble CD27 (sCD27) levels
关键词： CD70-CD27 Interaction |  Immunotherapy |  Melanoma |  Predictive Biomarker |  Tumor Microenvironment |  CTLA-4 BLOCKADE |  PD-1 BLOCKADE |  IMMUNOTHERAPY |  BIOMARKERS |  DISCOVERY...
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8. Targeting cIAP2 in a novel senolytic strategy prevents glioblastoma recurrence after radiotherapy

Tomimatsu, Nozomi |  Di Cristofaro, Luis ...... -  《embo molecular medicine》 - 2025,17(4) - 645～678 - 共34页

摘要：Glioblastomas (GBM) are routinely treated with |  high doses of ionizing radiation (IR), yet these |  tumors recur quickly, and the recurrent tumors are |  highly therapy resistant. Here, we report that IR | -induced senescence of tumor cells counterintuitively
关键词： Glioblastoma Recurrence |  Radiation Therapy |  Therapy-induced Senescence |  Senescence-associated Secretory Phenotype |  Senolytic Therapy |  NF-KAPPA-B |  PI3K/MTOR INHIBITOR NVP-BEZ235 |  SENESCENT CELLS |  CELLULAR SENESCENCE |  SECRETORY PHENOTYPE...
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9. Repression of apelin Furin cleavage sites provides antimetastatic strategy in colorectal cancer

Demoures, Beatrice |  Soulet, Fabienne... -  《embo molecular medicine》 - 2025,17(3) - 504～534 - 共31页

摘要：The adipokine apelin has been directly |  implicated in various physiological processes during |  embryogenesis and human cancers. Nevertheless, the importance |  of the conversion of its precursor proapelin to |  mature apelin in tumorigenesis remains unknown. In this
关键词： Apelin |  Furin |  Colon Cancer |  Liver Metastasis |  Safety Pharmacology |  TUMOR-CELLS |  WEB SERVER |  LIVER |  EXPRESSION |  RECEPTOR...
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10. FABP4 as a therapeutic host target controlling SARS-CoV-2 infection

Baazim, Hatoon |  Koyuncu, Emre... -  《embo molecular medicine》 - 2025,17(3) - 414～440 - 共27页

摘要：Host metabolic fitness is a critical |  determinant of infectious disease outcomes. Obesity, aging | , and other related metabolic disorders are recognized |  as high-risk disease modifiers for respiratory |  infections, including coronavirus infections, though the
关键词： FABP4 |  SARS-CoV-2 |  COVID-19 |  Replication Organelles |  Lipid Droplets |  FATTY-ACID-BINDING |  ADIPOSE-TISSUE |  PROTEIN AP2 |  IDENTIFICATION |  INFLAMMATION...
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