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1. Allostatic load and cardiometabolic health in a young adult South African population: the African-PREDICT study

Wentzel, A. | Smith, W.... - 《american journal of physiology-heart and circulatory physiology》 - 2025,328(3) - H581～H593 - 共13页

摘要：Sustained stress, assessed as a high | allostatic load score (ALS), is an independent | cardiovascular disease (CVD) risk factor in older adults but | its associations in young people are undefined | . Since neurological maturation impacts stress

关键词： allostasis | cardiometabolic health | neurological age | South Africa | stress | STRESS | RISK | REACTIVITY | MARKER | LINK

2. Heart and health behavior responses to GLP-1 receptor agonists: a 12-wk study using wearable technology and causal inference

Grosicki, Gregory J. | Kim, Jeongeun ... - 《american journal of physiology-heart and circulatory physiology》 - 2025,328(2) - H235～H241 - 共7页

摘要：Glucagon-like peptide-1 receptor agonists (GLP | -1 RAs) were originally developed for the treatment | of type 2 diabetes but have recently been approved | for chronic weight management and reducing | cardiovascular risk in individuals with overweight and obesity

关键词： anti-obesity medication | heart rate | heart rate variability | obesity | physical activity | WEIGHT-LOSS

3. Reduced microvascular flow-mediated dilation in Syrian hamsters lacking δ-sarcoglycan is caused by increased oxidative stress

Richard, Alexis | Bocquet, Arnaud ... - 《american journal of physiology-heart and circulatory physiology》 - 2025,328(1) - H75～H83 - 共9页

摘要：delta-Sarcoglycan mutation reduces | mechanotransduction and induces dilated cardiomyopathy with aging | . We hypothesized that in young hamsters with delta | -sarcoglycan mutation, which do not show cardiomyopathy, flow | mechanotransduction might be affected in resistance arteries as the

关键词： mechanotransduction | mutation | myopathy | resistance arteries | shear stress | VASCULAR SMOOTH-MUSCLE | ENDOTHELIAL DYSFUNCTION | NITRIC-OXIDE | RESISTANCE ARTERIES | SKELETAL-MUSCLE...

4. Endothelial cell-selective adhesion molecule deficiency exhibits increased pulmonary vascular resistance due to impaired endothelial nitric oxide signaling

Buncha, Vadym | Lang, Liwei ... - 《american journal of physiology-heart and circulatory physiology》 - 2025,328(2) - H283～H293 - 共11页 - 被引量：1

摘要：Endothelial cell-selective adhesion molecule | (ESAM) is a member of tight junction molecules, highly | abundant in the heart and the lung, and plays a role in | regulating endothelial cell permeability. We previously | reported that mice with genetic ESAM deficiency (ESAM

关键词： ESAM | nitric oxide synthase | pulmonary artery | pulmonary vascular resistance | PRESERVED EJECTION FRACTION | HEART-FAILURE | HYPERTENSION | JUNCTIONS | MAGI-1

5. A minimally invasive swine model of chronic kidney disease-associated heart failure

Mavropoulos, Spyros ... | Aikawa, Tadao ... - 《american journal of physiology-heart and circulatory physiology》 - 2025,328(2) - H260～H270 - 共11页 - 被引量：1

摘要：Chronic kidney disease (CKD) is on the rise | , and over 50% of patients die from cardiac causes | . Patients develop heart failure due to unelucidated reno | -cardiac interactions, termed type 4 cardiorenal syndrome | (CRS4). The aim of this study is to establish and

关键词： diastolic dysfunction | HFpEF | large animal model | type 4 cardiorenal syndrome | CARDIORENAL SYNDROME TYPE-4 | MICROVASCULAR RAREFACTION | CARDIOVASCULAR RISK | PATHOPHYSIOLOGY

6. The role of mechanosignaling in the control of myocardial mass

Landim-Vieira, Maico... | Morales, Paula F. Ni...... - 《american journal of physiology-heart and circulatory physiology》 - 2025,328(3) - H622～H638 - 共17页

摘要：Regulation of myocardial mass is key for | maintaining cardiovascular health. This review highlights | the complex and regulatory relationship between | mechanosignaling and myocardial mass, influenced by many internal | and external factors including hemodynamic and

关键词： mechanotransduction | misfolding | proteasome | protein degradation | protein homeostasis | FOXO TRANSCRIPTION FACTORS | ACTIVATED PROTEIN-KINASES | RING FINGER 1 | INDUCED CARDIAC-HYPERTROPHY | CANINE LEFT-VENTRICLE...

7. BRD4 inhibition rewires cardiac macrophages toward a protective phenotype marked by low MHC class II expression

Schuetze, Katherine ... | Stratton, Matthew S.... - 《american journal of physiology-heart and circulatory physiology》 - 2025,328(2) - H294～H309 - 共16页

摘要：Bromodomain and extraterminal domain (BET | ) proteins, including BRD4, bind acetylated chromatin and | coactivate gene transcription. A BET inhibitor, JQ1 | , prevents and reverses pathological cardiac remodeling in | preclinical models of heart failure. However, the underlying

关键词： BRD4 | cardiac | macrophage | SUPER-ENHANCERS | CELL IDENTITY | P-TEFB | TRANSCRIPTIONAL ELONGATION | SELECTIVE-INHIBITION | HEART | RECRUITMENT...

8. Reduced cofilin activity as a mechanism contributing to endothelial cell stiffening in type 2 diabetes

Power, Gavin | Lateef, Olubodun M.... - 《american journal of physiology-heart and circulatory physiology》 - 2025,328(1) - H84～H92 - 共9页

摘要：An emerging instigator of endothelial | dysfunction in type 2 diabetes (T2D) is the stiffening of | the cell. Previous reports suggest that | polymerization of filamentous actin (F-actin) is a potential | mediator of endothelial stiffening. Actin polymerization

关键词： cofilin | endothelial dysfunction | endothelial stiffening | F-actin | type 2 diabetes | FLOW-MEDIATED DILATION | OXIDATIVE STRESS | ACTIN

9. Comprehensive echocardiographic protocol for pigs with emphasis on diastolic function: advantages over MRI assessment

Naya, Nadia Martinez | Sharp, Thomas E.... - 《american journal of physiology-heart and circulatory physiology》 - 2025,328(3) - H401～H414 - 共14页

摘要：Swine are increasingly used in cardiovascular | research due to their anatomical and physiological | similarities to humans, particularly for studying diastolic | dysfunction. Although MRI offers excellent structural | imaging, echocardiography provides superior real-time

关键词： cardiac imaging | diastolic function | echocardiography | veterinary cardiology | Yorkshire pigs | HEART | ANESTHESIA | SWINE

10. Cardiac energy metabolism in diabetes: emerging therapeutic targets and clinical implications

Panwar, Archee | Malik, Sufyan O.... - 《american journal of physiology-heart and circulatory physiology》 - 2025,328(5) - H1089～H1112 - 共24页

摘要：Patients with diabetes are at an increased | risk for developing diabetic cardiomyopathy and other | cardiovascular complications. Alterations in cardiac energy | metabolism in patients with diabetes, including an increase | in mitochondrial fatty acid oxidation and a

关键词： diabetic cardiomyopathy | fatty acid beta-oxidation | glucose oxidation | mitochondria | FATTY-ACID OXIDATION | GLYCATION END-PRODUCTS | ACTIVATED RECEPTOR-ALPHA | NECROSIS-FACTOR-ALPHA | CHAIN AMINO-ACIDS | NF-KAPPA-B...

摘要：Sustained stress, assessed as a high | allostatic load score (ALS), is an independent | cardiovascular disease (CVD) risk factor in older adults but | its associations in young people are undefined | . Since neurological maturation impacts stress

关键词： allostasis | cardiometabolic health | neurological age | South Africa | stress | STRESS | RISK | REACTIVITY | MARKER | LINK

摘要：Glucagon-like peptide-1 receptor agonists (GLP | -1 RAs) were originally developed for the treatment | of type 2 diabetes but have recently been approved | for chronic weight management and reducing | cardiovascular risk in individuals with overweight and obesity

关键词： anti-obesity medication | heart rate | heart rate variability | obesity | physical activity | WEIGHT-LOSS

摘要：delta-Sarcoglycan mutation reduces | mechanotransduction and induces dilated cardiomyopathy with aging | . We hypothesized that in young hamsters with delta | -sarcoglycan mutation, which do not show cardiomyopathy, flow | mechanotransduction might be affected in resistance arteries as the

关键词： mechanotransduction | mutation | myopathy | resistance arteries | shear stress | VASCULAR SMOOTH-MUSCLE | ENDOTHELIAL DYSFUNCTION | NITRIC-OXIDE | RESISTANCE ARTERIES | SKELETAL-MUSCLE...

摘要：Endothelial cell-selective adhesion molecule | (ESAM) is a member of tight junction molecules, highly | abundant in the heart and the lung, and plays a role in | regulating endothelial cell permeability. We previously | reported that mice with genetic ESAM deficiency (ESAM

关键词： ESAM | nitric oxide synthase | pulmonary artery | pulmonary vascular resistance | PRESERVED EJECTION FRACTION | HEART-FAILURE | HYPERTENSION | JUNCTIONS | MAGI-1

摘要：Chronic kidney disease (CKD) is on the rise | , and over 50% of patients die from cardiac causes | . Patients develop heart failure due to unelucidated reno | -cardiac interactions, termed type 4 cardiorenal syndrome | (CRS4). The aim of this study is to establish and

关键词： diastolic dysfunction | HFpEF | large animal model | type 4 cardiorenal syndrome | CARDIORENAL SYNDROME TYPE-4 | MICROVASCULAR RAREFACTION | CARDIOVASCULAR RISK | PATHOPHYSIOLOGY

摘要：Regulation of myocardial mass is key for | maintaining cardiovascular health. This review highlights | the complex and regulatory relationship between | mechanosignaling and myocardial mass, influenced by many internal | and external factors including hemodynamic and

关键词： mechanotransduction | misfolding | proteasome | protein degradation | protein homeostasis | FOXO TRANSCRIPTION FACTORS | ACTIVATED PROTEIN-KINASES | RING FINGER 1 | INDUCED CARDIAC-HYPERTROPHY | CANINE LEFT-VENTRICLE...

摘要：Bromodomain and extraterminal domain (BET | ) proteins, including BRD4, bind acetylated chromatin and | coactivate gene transcription. A BET inhibitor, JQ1 | , prevents and reverses pathological cardiac remodeling in | preclinical models of heart failure. However, the underlying

关键词： BRD4 | cardiac | macrophage | SUPER-ENHANCERS | CELL IDENTITY | P-TEFB | TRANSCRIPTIONAL ELONGATION | SELECTIVE-INHIBITION | HEART | RECRUITMENT...

摘要：An emerging instigator of endothelial | dysfunction in type 2 diabetes (T2D) is the stiffening of | the cell. Previous reports suggest that | polymerization of filamentous actin (F-actin) is a potential | mediator of endothelial stiffening. Actin polymerization

关键词： cofilin | endothelial dysfunction | endothelial stiffening | F-actin | type 2 diabetes | FLOW-MEDIATED DILATION | OXIDATIVE STRESS | ACTIN

摘要：Swine are increasingly used in cardiovascular | research due to their anatomical and physiological | similarities to humans, particularly for studying diastolic | dysfunction. Although MRI offers excellent structural | imaging, echocardiography provides superior real-time

关键词： cardiac imaging | diastolic function | echocardiography | veterinary cardiology | Yorkshire pigs | HEART | ANESTHESIA | SWINE

摘要：Patients with diabetes are at an increased | risk for developing diabetic cardiomyopathy and other | cardiovascular complications. Alterations in cardiac energy | metabolism in patients with diabetes, including an increase | in mitochondrial fatty acid oxidation and a

关键词： diabetic cardiomyopathy | fatty acid beta-oxidation | glucose oxidation | mitochondria | FATTY-ACID OXIDATION | GLYCATION END-PRODUCTS | ACTIVATED RECEPTOR-ALPHA | NECROSIS-FACTOR-ALPHA | CHAIN AMINO-ACIDS | NF-KAPPA-B...

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