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1. Allostatic load and cardiometabolic health in a young adult South African population: the African-PREDICT study

Wentzel, A. |  Smith, W.... -  《american journal of physiology-heart and circulatory physiology》 - 2025,328(3) - H581~H593 - 共13页

摘要:Sustained stress, assessed as a high |  allostatic load score (ALS), is an independent |  cardiovascular disease (CVD) risk factor in older adults but |  its associations in young people are undefined | . Since neurological maturation impacts stress
关键词: allostasis |  cardiometabolic health |  neurological age |  South Africa |  stress |  STRESS |  RISK |  REACTIVITY |  MARKER |  LINK

2. Heart and health behavior responses to GLP-1 receptor agonists: a 12-wk study using wearable technology and causal inference

Grosicki, Gregory J. |  Kim, Jeongeun... -  《american journal of physiology-heart and circulatory physiology》 - 2025,328(2) - H235~H241 - 共7页

摘要:Glucagon-like peptide-1 receptor agonists (GLP | -1 RAs) were originally developed for the treatment |  of type 2 diabetes but have recently been approved |  for chronic weight management and reducing |  cardiovascular risk in individuals with overweight and obesity
关键词: anti-obesity medication |  heart rate |  heart rate variability |  obesity |  physical activity |  WEIGHT-LOSS

3. Reduced microvascular flow-mediated dilation in Syrian hamsters lacking δ-sarcoglycan is caused by increased oxidative stress

Richard, Alexis |  Bocquet, Arnaud... -  《american journal of physiology-heart and circulatory physiology》 - 2025,328(1) - H75~H83 - 共9页

摘要:delta-Sarcoglycan mutation reduces |  mechanotransduction and induces dilated cardiomyopathy with aging | . We hypothesized that in young hamsters with delta | -sarcoglycan mutation, which do not show cardiomyopathy, flow |  mechanotransduction might be affected in resistance arteries as the
关键词: mechanotransduction |  mutation |  myopathy |  resistance arteries |  shear stress |  VASCULAR SMOOTH-MUSCLE |  ENDOTHELIAL DYSFUNCTION |  NITRIC-OXIDE |  RESISTANCE ARTERIES |  SKELETAL-MUSCLE...

4. Endothelial cell-selective adhesion molecule deficiency exhibits increased pulmonary vascular resistance due to impaired endothelial nitric oxide signaling

Buncha, Vadym |  Lang, Liwei... -  《american journal of physiology-heart and circulatory physiology》 - 2025,328(2) - H283~H293 - 共11页 - 被引量:1

摘要:Endothelial cell-selective adhesion molecule |  (ESAM) is a member of tight junction molecules, highly |  abundant in the heart and the lung, and plays a role in |  regulating endothelial cell permeability. We previously |  reported that mice with genetic ESAM deficiency (ESAM
关键词: ESAM |  nitric oxide synthase |  pulmonary artery |  pulmonary vascular resistance |  PRESERVED EJECTION FRACTION |  HEART-FAILURE |  HYPERTENSION |  JUNCTIONS |  MAGI-1

5. A minimally invasive swine model of chronic kidney disease-associated heart failure

Mavropoulos, Spyros ... |  Aikawa, Tadao... -  《american journal of physiology-heart and circulatory physiology》 - 2025,328(2) - H260~H270 - 共11页 - 被引量:1

摘要:Chronic kidney disease (CKD) is on the rise | , and over 50% of patients die from cardiac causes | . Patients develop heart failure due to unelucidated reno | -cardiac interactions, termed type 4 cardiorenal syndrome |  (CRS4). The aim of this study is to establish and
关键词: diastolic dysfunction |  HFpEF |  large animal model |  type 4 cardiorenal syndrome |  CARDIORENAL SYNDROME TYPE-4 |  MICROVASCULAR RAREFACTION |  CARDIOVASCULAR RISK |  PATHOPHYSIOLOGY

6. Reduced cofilin activity as a mechanism contributing to endothelial cell stiffening in type 2 diabetes

Power, Gavin |  Lateef, Olubodun M.... -  《american journal of physiology-heart and circulatory physiology》 - 2025,328(1) - H84~H92 - 共9页

摘要:An emerging instigator of endothelial |  dysfunction in type 2 diabetes (T2D) is the stiffening of |  the cell. Previous reports suggest that |  polymerization of filamentous actin (F-actin) is a potential |  mediator of endothelial stiffening. Actin polymerization
关键词: cofilin |  endothelial dysfunction |  endothelial stiffening |  F-actin |  type 2 diabetes |  FLOW-MEDIATED DILATION |  OXIDATIVE STRESS |  ACTIN

7. Comprehensive echocardiographic protocol for pigs with emphasis on diastolic function: advantages over MRI assessment

Naya, Nadia Martinez |  Sharp, Thomas E.... -  《american journal of physiology-heart and circulatory physiology》 - 2025,328(3) - H401~H414 - 共14页

摘要:Swine are increasingly used in cardiovascular |  research due to their anatomical and physiological |  similarities to humans, particularly for studying diastolic |  dysfunction. Although MRI offers excellent structural |  imaging, echocardiography provides superior real-time
关键词: cardiac imaging |  diastolic function |  echocardiography |  veterinary cardiology |  Yorkshire pigs |  HEART |  ANESTHESIA |  SWINE

8. Cardiac energy metabolism in diabetes: emerging therapeutic targets and clinical implications

Panwar, Archee |  Malik, Sufyan O.... -  《american journal of physiology-heart and circulatory physiology》 - 2025,328(5) - H1089~H1112 - 共24页

摘要:Patients with diabetes are at an increased |  risk for developing diabetic cardiomyopathy and other |  cardiovascular complications. Alterations in cardiac energy |  metabolism in patients with diabetes, including an increase |  in mitochondrial fatty acid oxidation and a
关键词: diabetic cardiomyopathy |  fatty acid beta-oxidation |  glucose oxidation |  mitochondria |  FATTY-ACID OXIDATION |  GLYCATION END-PRODUCTS |  ACTIVATED RECEPTOR-ALPHA |  NECROSIS-FACTOR-ALPHA |  CHAIN AMINO-ACIDS |  NF-KAPPA-B...

9. Associations of circulating T cell subsets with endothelial function: the Multi-Ethnic Study of Atherosclerosis

Deconne, Theodore M. |  Sitlani, Colleen M.... -  《american journal of physiology-heart and circulatory physiology》 - 2025,328(6) - H1374~H1379 - 共6页

摘要:Endothelial dysfunction has emerged as a risk |  factor for many age-related diseases such as |  cardiovascular disease and Alzheimer's disease and related |  dementias. T-lymphocytes (T cells) have been identified as |  important regulators of endothelial function in multiple
关键词: aging |  endothelial function |  epidemiology |  risk factors |  T cells |  DISEASE

10. PVAT adipocyte: energizing, modulating, and structuring vascular function during normotensive and hypertensive states

Rendon, C. Javier |  Watts, Stephanie W.... -  《american journal of physiology-heart and circulatory physiology》 - 2025,328(6) - H1204~H1217 - 共14页

摘要:Hypertension represents the most common form |  of cardiovascular disease. It is characterized by |  significant remodeling of the various layers of the vascular |  system, including the outermost layer: the perivascular |  adipose tissue (PVAT). Given the tissue's pivotal role
关键词: adipocyte |  cardiovascular disease |  hypertension |  inflammation |  perivascular adipose tissue |  PERIVASCULAR ADIPOSE-TISSUE |  RENIN-ANGIOTENSIN SYSTEM |  ACTIVATED-RECEPTOR-GAMMA |  AORTIC ADVENTITIAL FIBROBLASTS |  II-INDUCED HYPERTENSION...
检索条件出处:american journal of physiology-heart and circulatory physiology
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