NSTL国家科技图书文献中心

1. Wasp Venom: Future Breakthrough in Production of Antimicrobial Peptides NSTL国家科技图书文献中心

Bhattacharya, Bikram... | Bhattacharya, Shresh...... - 《The protein journal》 - 2025,44(1) - 35～47 - 共13页

摘要：The emergence of multi-drug-resistant | pathogens and the decrease in the discovery of newer | antibiotics have led to a quest for novel alternatives | . Recently, wasp venom has spiked interest due to the | presence of various active compounds, showcasing a

关键词： Insects | Wasp | Venom | Protein | Polybia paulista | Antimicrobial agent

2. Impression of Insect's Proteolytic Enzyme Cocoonase and Its Application: A Comprehensive Review NSTL国家科技图书文献中心

Rani, Aruna | Pandey, Dev Mani ... - 《The protein journal》 - 2025,44(1) - 48～61 - 共14页

摘要：Cocoonase is a naturally secreted protease | responsible for facilitating moth emergence from inside of | cocoon. This protease is considered as of prime | importance for all the cocooning lepidopteron. It | specifically degrades sericin, the glue protein of the cocoon

关键词： Cocoonase | Trypsin-like | Serine protease | Degumming

3. Therapeutic Potential of FTO Demethylase in Metabolism and Disease Pathways NSTL国家科技图书文献中心

Somala, Chaitanya Sr... | Sathyapriya, Selvara...... - 《The protein journal》 - 2025,44(1) - 21～34 - 共14页

摘要：The crucial involvement of the Fat Mass and | Obesity-associated (FTO) protein in both metabolic and | non-metabolic diseases has been documented since its | discovery. This enzyme, known as FTO, is a demethylase | that belongs to the 2-oxoglutarate-dependent nucleic

关键词： FTO Protein | Metabolic diseases | Non-metabolic diseases | Obesity | Diabetes | Cardiovascular diseases | Cancer | Neurological disorders | Therapeutic implications.

4. Infrared Spectral Patterns of Thyroglobulin Bearing Thyroiditogenic Epitopes NSTL国家科技图书文献中心

Cherepanov, Igor | Sidorov, Alexandr ... - 《The protein journal》 - 2025,44(1) - 68～78 - 共11页

摘要：Thyroglobulin is a major autoantigen to which | autoimmune response, destroying the thyroid gland in | Hashimoto's thyroiditis, is directed. To detect a | pathological autoimmune response to thyroglobulin, as well as | the successful induction of experimental autoimmune

关键词： FTIR spectroscopy | Freshly isolated thyroglobulin | Lyophilized thyroglobulin | Thyroiditogenicity | Phenylmethylsulfonyl fluoride

5. Ferguson Plot Analysis of Chaperone ClpB from Moderate Halophile NSTL国家科技图书文献中心

Akuta, Teruo | Tomioka, Yui ... - 《The protein journal》 - 2025,44(1) - 79～87 - 共9页

摘要：The Ferguson plot is a simple method for | determining the molecular weight of native proteins and | their complexes. In this study, we tested the validity | of the Ferguson plot based on agarose native gel | electrophoresis using multimeric chaperone protein, ClpB

关键词： Ferguson plot | ClpB | Chaperone | Assembly

6. DAAO Mutant Sites among Different Mice Strains and Their Effects on Enzyme Activity NSTL国家科技图书文献中心

Zhou, Yu-Cong | Fu, Sheng-Ling ... - 《The protein journal》 - 2025,44(1) - 102～112 - 共11页

摘要：Previous studies reported that D-amino acid | oxidase (DAAO) activity was closely associated with | neuropathic pain, cognitive characteristics of schizophrenia | and so on. To determine DAAO mutant sites in | different strains of mice and their effects on enzyme

关键词： DAAO mutants | Enzyme activity | Compound SUN | CBIO | Heterologous expression | Kinetic constants | Affinity

7. The Root-Tuber Trypsin Inhibitor of Winged Bean and Its Anti-cancerous Activity Against Osteosarcoma Cell-Line NSTL国家科技图书文献中心

Lone, Rayees Ahmad | Kumar, Bhupendra ... - 《The protein journal》 - 2025,44(1) - 88～101 - 共14页

摘要：Trypsin inhibitor from the root-tuber of | underutilized legume Winged bean (Psophocarpus tetragonolobus | (L.) DC.) (WbT-TI) was purified using ion exchange | chromatography followed by size-exclusion chromatography. The | purified WbT-TI showed a molecular mass of 20,609 Da and

关键词： Trypsin inhibitor | Root-tuber | Winged bean | Kunitz-type | Anticancer

8. Antibody Aggregation: A Problem Within the Biopharmaceutical Industry and Its Role in AL Amyloidosis Disease NSTL国家科技图书文献中心

Sheehan, Kate | Jeon, Hyesoo ... - 《The protein journal》 - 2025,44(1) - 1～20 - 共20页

摘要：Due to the large size and rapid growth of the | global therapeutic antibody market, there is major | interest in understanding the aggregation of protein | products as it can compromise efficacy, concentration | , and safety. Various production and storage

关键词： Antibody | Aggregation | Protein misfolding | Monoclonal antibody | Excipient | AL amyloidosis

9. Exploring Acoustic Detection of α-Synuclein Fibrils NSTL国家科技图书文献中心

Brun-Cosme-Bruny, M. | Gerfault, L.... - 《The protein journal》 - 2025,44(1) - 62～67 - 共6页

摘要：Over the past decades, the incidence of | Parkinson's disease (PD) cases has doubled in industrialized | countries. While patients over 70 years old still | represent more than half of the cases, the disease is | increasingly affecting younger individuals. Environmental

关键词： alpha-synuclein | Fibrils | Frequency | Spectrum | Ultrasounds

10. Exploring the Potential of Arginine to Increase Coelenterazine- Renilla Luciferase Affinity and Enzyme Stability: Kinetic and Molecular Dynamics Studies NSTL国家科技图书文献中心

Salehian, Maryam | Emamzadeh, Rahman ... - 《The protein journal》 - 2024,43(4) - 739～750 - 共12页

摘要：Renilla luciferase catalyzes the oxidation of | coelenterazine to coelenteramide and results in the emission of | a photon of light. Although Renilla luciferase has | various applications in biotechnology, its low thermal | stability limits the development of its applications

摘要：The emergence of multi-drug-resistant | pathogens and the decrease in the discovery of newer | antibiotics have led to a quest for novel alternatives | . Recently, wasp venom has spiked interest due to the | presence of various active compounds, showcasing a

关键词： Insects | Wasp | Venom | Protein | Polybia paulista | Antimicrobial agent

摘要：Cocoonase is a naturally secreted protease | responsible for facilitating moth emergence from inside of | cocoon. This protease is considered as of prime | importance for all the cocooning lepidopteron. It | specifically degrades sericin, the glue protein of the cocoon

关键词： Cocoonase | Trypsin-like | Serine protease | Degumming

摘要：The crucial involvement of the Fat Mass and | Obesity-associated (FTO) protein in both metabolic and | non-metabolic diseases has been documented since its | discovery. This enzyme, known as FTO, is a demethylase | that belongs to the 2-oxoglutarate-dependent nucleic

关键词： FTO Protein | Metabolic diseases | Non-metabolic diseases | Obesity | Diabetes | Cardiovascular diseases | Cancer | Neurological disorders | Therapeutic implications.

摘要：Thyroglobulin is a major autoantigen to which | autoimmune response, destroying the thyroid gland in | Hashimoto's thyroiditis, is directed. To detect a | pathological autoimmune response to thyroglobulin, as well as | the successful induction of experimental autoimmune

关键词： FTIR spectroscopy | Freshly isolated thyroglobulin | Lyophilized thyroglobulin | Thyroiditogenicity | Phenylmethylsulfonyl fluoride

摘要：The Ferguson plot is a simple method for | determining the molecular weight of native proteins and | their complexes. In this study, we tested the validity | of the Ferguson plot based on agarose native gel | electrophoresis using multimeric chaperone protein, ClpB

关键词： Ferguson plot | ClpB | Chaperone | Assembly

摘要：Previous studies reported that D-amino acid | oxidase (DAAO) activity was closely associated with | neuropathic pain, cognitive characteristics of schizophrenia | and so on. To determine DAAO mutant sites in | different strains of mice and their effects on enzyme

关键词： DAAO mutants | Enzyme activity | Compound SUN | CBIO | Heterologous expression | Kinetic constants | Affinity

摘要：Trypsin inhibitor from the root-tuber of | underutilized legume Winged bean (Psophocarpus tetragonolobus | (L.) DC.) (WbT-TI) was purified using ion exchange | chromatography followed by size-exclusion chromatography. The | purified WbT-TI showed a molecular mass of 20,609 Da and

关键词： Trypsin inhibitor | Root-tuber | Winged bean | Kunitz-type | Anticancer

摘要：Due to the large size and rapid growth of the | global therapeutic antibody market, there is major | interest in understanding the aggregation of protein | products as it can compromise efficacy, concentration | , and safety. Various production and storage

关键词： Antibody | Aggregation | Protein misfolding | Monoclonal antibody | Excipient | AL amyloidosis

摘要：Over the past decades, the incidence of | Parkinson's disease (PD) cases has doubled in industrialized | countries. While patients over 70 years old still | represent more than half of the cases, the disease is | increasingly affecting younger individuals. Environmental

关键词： alpha-synuclein | Fibrils | Frequency | Spectrum | Ultrasounds

摘要：Renilla luciferase catalyzes the oxidation of | coelenterazine to coelenteramide and results in the emission of | a photon of light. Although Renilla luciferase has | various applications in biotechnology, its low thermal | stability limits the development of its applications

关键词： Renilla luciferase | Arginine | Catalytic efficiency | Molecular dynamics simulation | Coelenteramide

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