NSTL国家科技图书文献中心

1. Insufficient secretion of pancreatic FGF21 is the toxicological mechanism and therapeutic target of asparaginase-associated pancreatitis NSTL国家科技图书文献中心

He J. | Chen Y.... - 《Toxicology and Applied Pharmacology》 - 2024,485 - 116920～116920 - 共6页

摘要：? 2024 Elsevier Inc.Asparaginase-associated | pancreatitis (AAP) is a severe and potentially life | -threatening drug-induced pancreas targeted toxicity in the | combined chemotherapy of acute lymphoblastic leukemia | among children and adolescents. The toxicological

关键词： Asparaginase | Asparaginase-Associated Pancreatitis | Fibroblast Growth Factor 21

2. Berberine alleviated contrast-induced acute kidney injury by mitophagy-mediated NLRP3 inflammasome inactivation in a mice model NSTL国家科技图书文献中心

Yang Y. | Jiang S.... - 《Toxicology and Applied Pharmacology》 - 2024,486 - 116952～116952 - 共6页 - 被引量：2

摘要：? 2024The incidence of contrast-induced acute | kidney injury (CI-AKI) has escalated to become the | third most prevalent cause of hospital-acquired AKI | , with a lack of efficacious interventions. Berberine | (BBR) possesses diverse pharmacological effects and

关键词： Berberine | Contrast-induced acute kidney injury | Damage-associated molecular patterns | NLRP3 inflammasome | Mitophagy

3. BDNF mimetics recover palmitic acid-induced injury in cardiomyocytes by ameliorating Akt-dependent mitochondrial impairments NSTL国家科技图书文献中心

Zhang M.-R. | Zuo B.-Y.... - 《Toxicology and Applied Pharmacology》 - 2024,486 - 116951～116951 - 共6页

摘要：? 2024 Elsevier Inc.Cardiac lipotoxicity is a | prevalent consequence of lipid metabolism disorders | occurring in cardiomyocytes, which in turn precipitates | the onset of heart failure. Mimetics of brain | -derived neurotrophic factor (BDNF), such as 7,8

关键词： 7 | 8 | 3′-trihydroxyflavone | 8-dihydroxyflavone | Akt | Mitochondria | Palmitic acid

4. L-theanine abates oxidative stress and mitochondrial dysfunction in myocardial ischemia-reperfusion injury by positively regulating the antioxidant response NSTL国家科技图书文献中心

Garcia-Nino W.R. | Correa F.... - 《Toxicology and Applied Pharmacology》 - 2024,486 - 116940～116940 - 共6页

摘要：? 2024 Elsevier Inc.L-theanine (L-THE), a non | -protein amino acid isolated from Camelia sinensis, has | antioxidant properties that could prevent oxidative damage | and mitochondrial dysfunction generated by | myocardial ischemia and reperfusion (I/R) injury. The

关键词： Antioxidants | Cardioprotection | Mitochondrial dysfunction | Oxidative stress

5. Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury NSTL国家科技图书文献中心

Zhang S. | Zhao N.... - 《Toxicology and Applied Pharmacology》 - 2024,485 - 116890～116890 - 共6页

摘要：? 2024 Elsevier Inc.Ricin (ricin toxin, RT | ) has the potential to cause damage to multiple organs | and systems. Currently, there are no existing | antidotes, vaccinations, or effective therapies to prevent | or treat RT intoxication. Apart from halting

关键词： Autophagy | Interaction | NLRP3 inflammasome | Ricin | ROS

6. ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting CEMIP-mediated EMT NSTL国家科技图书文献中心

Gao L. | Qiao L.... - 《Toxicology and Applied Pharmacology》 - 2024,483 - 116807～116807 - 共6页 - 被引量：2

摘要：? 2024 Elsevier Inc.N6-methyladenosine (m6A | ) is the most prevalent mRNA modification, and it is | verified to be closely correlated with cancer occurrence | and progression. The m6A demethylase ALKBH5 (alkB | homolog 5) is dysregulated in various cancers. However

关键词： ALKBH5 | CEMIP | EMT | Non-small cell lung cancer | PTX-resistance

7. Predicting the in vivo developmental toxicity of fenarimol from in vitro toxicity data using PBTK modelling-facilitated reverse dosimetry approach NSTL国家科技图书文献中心

Bhateria M. | Taneja I.... - 《Toxicology and Applied Pharmacology》 - 2024,484 - 116879～116879 - 共6页

摘要：? 2024 Elsevier Inc.In vitro methods are | widely used in modern toxicological testing; however | , the data cannot be directly employed for risk | assessment. In vivo toxicity of chemicals can be predicted | from in vitro data using physiologically based

关键词： Developmental toxicity | Fungicides | Health risk assessment | Monte Carlo simulations | PBTK model | Uncertainty factor

8. MicroRNA-195-5p mediates arsenic-induced cytotoxicity in human lung epithelial cells: Beneficial role of plant-derived tannic acid NSTL国家科技图书文献中心

Mishra, Sehal | Kalra, Neetu ... - 《Toxicology and Applied Pharmacology》 - 2024,482 - 116775～116775 - 共6页 - 被引量：1

摘要：Arsenic (As), a highly toxic metalloid, which | causes environmental lung diseases and affects millions | of people worldwide. Respiratory epithelial cells | are essential for maintaining lung homeostasis | , aberrant epithelial damage and death due to exposure to a

关键词： Inorganic arsenic | Cytotoxicity | Lung epithelial ells | miRNA-195-5p | Tannic acid | Therapeutic role | OXIDATIVE STRESS | APOPTOSIS | P27

9. Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices NSTL国家科技图书文献中心

Bellomo A. | Herbert J.... - 《Toxicology and Applied Pharmacology》 - 2024,486 - 116941～116941 - 共6页 - 被引量：1

摘要：? 2024 The AuthorsNitrogen mustard (NM | ; mechlorethamine) is a cytotoxic vesicant known to cause acute | lung injury which can progress to chronic disease | . Due to the complex nature of NM injury, it has been | difficult to analyze early responses of resident lung

关键词： Lung injury | Mustard vesicants | Oxidative stress | Precision cut lung slices

10. Tetramethylpyrazine inhibits the inflammatory response by downregulating the TNFR1/IκB-α/NF-κB p65 pathway after spinal cord injury NSTL国家科技图书文献中心

Liu G. | Huo L.... - 《Toxicology and Applied Pharmacology》 - 2024,484 - 116872～116872 - 共6页 - 被引量：2

摘要：? 2024Previous studies have demonstrated that | tetramethylpyrazine (TMP) can enhance the recovery of motor function | in spinal cord injury (SCI) rats. However, the | underlying mechanism involved in this therapeutic effect | remains to be elucidated. We conducted RNA sequencing