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1. Targeting VEGF With 99mTc‐Labeled Ranibizumab for Noninvasive Diagnosis of Non‐Small Cell Lung Cancer NSTL国家科技图书文献中心

Muhammad Shehzad Sal... | Syed Qaiser Shah - 《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(7/8) - e4150～e4150 - 共6页

摘要：ABSTRACT Angiogenesis, particularly driven by | the overexpression of vascular endothelial growth | factor (VEGF), plays a crucial role in the growth and | metastasis of tumors, making VEGF a significant target in | the diagnosis and therapy of non‐small cell lung

关键词： 99mTc | labelling | NSCLC | ranibizumab

2. Preparation of Macrobicyclic Cryptands for Radiometal Complexation Preparation of Macropa-Based Cryptands for Efficient Complexation of Radiometals NSTL国家科技图书文献中心

Hoeffmann, Laura | Blei, Magdalena ... - 《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(3) - e4136～e4136 - 共9页

摘要：Macrobicyclic cryptands and especially | derivatives with functionalized side arms (picolinate | , pyrimidine carboxylate, and bipyridine carboxylate) are | able to complex metal ions effectively. In this | regard, four new functionalized cryptands were prepared

关键词： cryptands | NMR titration | radiolabeling | stability

3. Synthesis of 18F-Labeled FC-119S and Its Tosyl Precursor NSTL国家科技图书文献中心

Koichi Kato, Makoto ... - 《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(5/6) - e4145～e4145 - 共6页

摘要：Animal models of Alzheimer's disease (AD) are | essential for developing therapeutics and evaluating the | efficacy of new drug candidates. Positron emission | tomography (PET) is a useful method to monitor a major | hallmark of the onset of AD, namely, the deposition of

关键词： Alzheimer's disease; amyloid plaques; animal models; in vivo imaging; positron emission

4. Synthesis and Preliminary Evaluation of an In Vivo Stable 131I-Labeled Deuterated Tropane for Mapping Dopamine Transporter NSTL国家科技图书文献中心

Jiaojiao Zuo, Jing K... - 《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(5/6) - e4147～e4147 - 共9页

摘要：Dopamine transporter (DAT) is closely | associated with neurodegenerative diseases such as | Parkinson's disease (PD). To develop an in vivo stable | radioligand targeting DAT, we synthesized a novel iodine-131 | -labeled tropane analog [131I]1 with deuteration on both

关键词： Parkinson's disease; deuterium; dopamine transporter.

5. A Novel 68 Ga-Labeled 2-Azabicyclo[3.1.0]Hexane-3-Carbonitrile-Based Fibroblast Activation Protein-Targeted Tracer for Cancer Imaging With Positron Emission Tomography NSTL国家科技图书文献中心

Chen, Chao-Cheng | Wang, Lei ... - 《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(3) - e4143～e4143 - 共6页

摘要：Most of the reported small molecule-based | fibroblast activation protein (FAP)-targeted radioligands | are derived from UAMC1110 and contain a 4-difluoro-2 | -cyanopyrrolidine moiety. In this study, we investigated the | effect of replacing the 4-difluoro-2-cyanopyrrolidine

关键词： azabicyclohexane | fibroblast activation protein inhibitor | gallium‐68 | positron emission tomography | gallium-68

6. Automated Radiolabeling and Evaluation of [ 18 F]FPMBBG: A Novel Cardiac Neuronal PET Imaging Agent NSTL国家科技图书文献中心

Ju, Min | Ren, Wanjie ... - 《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(3) - e4139～e4139 - 共8页

摘要：This study reports the automated | radiosynthesis and evaluation of [F-18]FPMBBG, a | radiopharmaceutical designed to target the norepinephrine | transporter (NET). A newly developed fully protected | benzylguanidine precursor, which prevents interference from non

关键词： automated radiosynthesis | cardiac sympathetic nervous system | fluorine-18 | norepinephrine transporter | positron emission tomography | fluorine‐18

7. Ultrasound-Assisted Microcontinuous Process Facilitates the Selective Deuteration of Steroid Hormones NSTL国家科技图书文献中心

Dan Wang, Xin Lv, Fa... - 《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(5/6) - e4146～e4146 - 共10页

摘要：Constructing deuterated molecules efficiently | and practically has been a long-standing challenge | . Deuterated steroid hormones are essential for medical | research and drug metabolism studies and are thus in high | demand; mild and selective methods for the deuteration

关键词： H/D exchange; gram‐scale synthesis; microcontinuous; steroid hormones; ultrasound.

8. Evaluation of New-Modelled Recombinant Human Insulin (rh-Insulin) Analog Expressed in E. coli Using Radioiodination Technique Followed by In Vivo Biodistribution in Diabetes-Induced Mice NSTL国家科技图书文献中心

Abdelaziz, Gamal | Abdelghany, Ibrahim ...... - 《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(1/2) - e4134～e4134 - 共7页

摘要：Biologists have significantly improved various | techniques for confirming the physiological and | pharmacological activity of new proteins produced by recombinant | DNA technology, such as Western blotting, ELISA, and | flow cytometry. Although these methods are costly and

关键词： I-125-rh-Insulin | diabetes mellitus | in vivo biodistribution | RCY | 125I‐rh‐Insulin

9. Design and Synthesis of a 18 F-Radiolabeled Pyrrolo[2,3- d ]pyrimidine Ligand as a CSF1R Receptor PET Imaging Agent NSTL国家科技图书文献中心

Cherukupalli, Sriniv... | Karlsen, Morten ... - 《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(1/2) - e4131～e4131 - 共8页

摘要：Colony-stimulating factor 1 receptor (CSF1R or | c-FMS), a class III receptor tyrosine kinase, is | significantly expressed in mononuclear phagocytes and in the | central nervous system. It has been identified as a | potential drug and imaging target in numerous inflammatory

关键词： CSF1R receptor | fluorine-18 | pyrrolo[2,3-d]pyrimidine | radiochemistry | tosylate leaving group | fluorine‐18 | pyrrolo[2,3‐d]pyrimidine

10. Synthesis and Imaging of Novel CDK19-Targeted Tracers Incorporating an Albumin-Binding Moiety NSTL国家科技图书文献中心

Li, Panfeng | Yang, Zhao ... - 《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(3) - e4130～e4130 - 共10页

摘要：Cyclin-dependent kinase 19 (CDK19) is a | potential target for the diagnosis and treatment of | prostate cancer. We have previously studied a series of | CDK19-targeted PET tracers, but in-depth drug | optimization is needed to improve the physiochemical

摘要：ABSTRACT Angiogenesis, particularly driven by | the overexpression of vascular endothelial growth | factor (VEGF), plays a crucial role in the growth and | metastasis of tumors, making VEGF a significant target in | the diagnosis and therapy of non‐small cell lung

关键词： 99mTc | labelling | NSCLC | ranibizumab

摘要：Macrobicyclic cryptands and especially | derivatives with functionalized side arms (picolinate | , pyrimidine carboxylate, and bipyridine carboxylate) are | able to complex metal ions effectively. In this | regard, four new functionalized cryptands were prepared

关键词： cryptands | NMR titration | radiolabeling | stability

摘要：Animal models of Alzheimer's disease (AD) are | essential for developing therapeutics and evaluating the | efficacy of new drug candidates. Positron emission | tomography (PET) is a useful method to monitor a major | hallmark of the onset of AD, namely, the deposition of

关键词： Alzheimer's disease; amyloid plaques; animal models; in vivo imaging; positron emission

摘要：Dopamine transporter (DAT) is closely | associated with neurodegenerative diseases such as | Parkinson's disease (PD). To develop an in vivo stable | radioligand targeting DAT, we synthesized a novel iodine-131 | -labeled tropane analog [131I]1 with deuteration on both

关键词： Parkinson's disease; deuterium; dopamine transporter.

摘要：Most of the reported small molecule-based | fibroblast activation protein (FAP)-targeted radioligands | are derived from UAMC1110 and contain a 4-difluoro-2 | -cyanopyrrolidine moiety. In this study, we investigated the | effect of replacing the 4-difluoro-2-cyanopyrrolidine

关键词： azabicyclohexane | fibroblast activation protein inhibitor | gallium‐68 | positron emission tomography | gallium-68

摘要：This study reports the automated | radiosynthesis and evaluation of [F-18]FPMBBG, a | radiopharmaceutical designed to target the norepinephrine | transporter (NET). A newly developed fully protected | benzylguanidine precursor, which prevents interference from non

关键词： automated radiosynthesis | cardiac sympathetic nervous system | fluorine-18 | norepinephrine transporter | positron emission tomography | fluorine‐18

摘要：Constructing deuterated molecules efficiently | and practically has been a long-standing challenge | . Deuterated steroid hormones are essential for medical | research and drug metabolism studies and are thus in high | demand; mild and selective methods for the deuteration

关键词： H/D exchange; gram‐scale synthesis; microcontinuous; steroid hormones; ultrasound.

摘要：Biologists have significantly improved various | techniques for confirming the physiological and | pharmacological activity of new proteins produced by recombinant | DNA technology, such as Western blotting, ELISA, and | flow cytometry. Although these methods are costly and

关键词： I-125-rh-Insulin | diabetes mellitus | in vivo biodistribution | RCY | 125I‐rh‐Insulin

摘要：Colony-stimulating factor 1 receptor (CSF1R or | c-FMS), a class III receptor tyrosine kinase, is | significantly expressed in mononuclear phagocytes and in the | central nervous system. It has been identified as a | potential drug and imaging target in numerous inflammatory

关键词： CSF1R receptor | fluorine-18 | pyrrolo[2,3-d]pyrimidine | radiochemistry | tosylate leaving group | fluorine‐18 | pyrrolo[2,3‐d]pyrimidine

摘要：Cyclin-dependent kinase 19 (CDK19) is a | potential target for the diagnosis and treatment of | prostate cancer. We have previously studied a series of | CDK19-targeted PET tracers, but in-depth drug | optimization is needed to improve the physiochemical

关键词： albumin binder | CDK19 | PET imaging | prostate cancer | radiotraces

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