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1. Targeting VEGF With 99mTc‐Labeled Ranibizumab for Noninvasive Diagnosis of Non‐Small Cell Lung Cancer NSTL国家科技图书文献中心

Muhammad Shehzad Sal... |  Syed Qaiser Shah -  《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(7/8) - e4150~e4150 - 共6页

摘要:ABSTRACT Angiogenesis, particularly driven by |  the overexpression of vascular endothelial growth |  factor (VEGF), plays a crucial role in the growth and |  metastasis of tumors, making VEGF a significant target in |  the diagnosis and therapy of non‐small cell lung
关键词: 99mTc |  labelling |  NSCLC |  ranibizumab

2. Preparation of Macrobicyclic Cryptands for Radiometal Complexation Preparation of Macropa-Based Cryptands for Efficient Complexation of Radiometals NSTL国家科技图书文献中心

Hoeffmann, Laura |  Blei, Magdalena... -  《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(3) - e4136~e4136 - 共9页

摘要:Macrobicyclic cryptands and especially |  derivatives with functionalized side arms (picolinate | , pyrimidine carboxylate, and bipyridine carboxylate) are |  able to complex metal ions effectively. In this |  regard, four new functionalized cryptands were prepared
关键词: cryptands |  NMR titration |  radiolabeling |  stability

3. Synthesis of 18F-Labeled FC-119S and Its Tosyl Precursor NSTL国家科技图书文献中心

Koichi Kato, Makoto ... -  《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(5/6) - e4145~e4145 - 共6页

摘要:Animal models of Alzheimer's disease (AD) are |  essential for developing therapeutics and evaluating the |  efficacy of new drug candidates. Positron emission |  tomography (PET) is a useful method to monitor a major |  hallmark of the onset of AD, namely, the deposition of
关键词: Alzheimer's disease; amyloid plaques; animal models; in vivo imaging; positron emission

4. Synthesis and Preliminary Evaluation of an In Vivo Stable 131I-Labeled Deuterated Tropane for Mapping Dopamine Transporter NSTL国家科技图书文献中心

Jiaojiao Zuo, Jing K... -  《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(5/6) - e4147~e4147 - 共9页

摘要:Dopamine transporter (DAT) is closely |  associated with neurodegenerative diseases such as |  Parkinson's disease (PD). To develop an in vivo stable |  radioligand targeting DAT, we synthesized a novel iodine-131 | -labeled tropane analog [131I]1 with deuteration on both
关键词: Parkinson's disease; deuterium; dopamine transporter.

5. A Novel 68 Ga-Labeled 2-Azabicyclo[3.1.0]Hexane-3-Carbonitrile-Based Fibroblast Activation Protein-Targeted Tracer for Cancer Imaging With Positron Emission Tomography NSTL国家科技图书文献中心

Chen, Chao-Cheng |  Wang, Lei... -  《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(3) - e4143~e4143 - 共6页

摘要:Most of the reported small molecule-based |  fibroblast activation protein (FAP)-targeted radioligands |  are derived from UAMC1110 and contain a 4-difluoro-2 | -cyanopyrrolidine moiety. In this study, we investigated the |  effect of replacing the 4-difluoro-2-cyanopyrrolidine
关键词: azabicyclohexane |  fibroblast activation protein inhibitor |  gallium‐68 |  positron emission tomography |  gallium-68

6. Automated Radiolabeling and Evaluation of [ 18 F]FPMBBG: A Novel Cardiac Neuronal PET Imaging Agent NSTL国家科技图书文献中心

Ju, Min |  Ren, Wanjie... -  《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(3) - e4139~e4139 - 共8页

摘要:This study reports the automated |  radiosynthesis and evaluation of [F-18]FPMBBG, a |  radiopharmaceutical designed to target the norepinephrine |  transporter (NET). A newly developed fully protected |  benzylguanidine precursor, which prevents interference from non
关键词: automated radiosynthesis |  cardiac sympathetic nervous system |  fluorine-18 |  norepinephrine transporter |  positron emission tomography |  fluorine‐18

7. Ultrasound-Assisted Microcontinuous Process Facilitates the Selective Deuteration of Steroid Hormones NSTL国家科技图书文献中心

Dan Wang, Xin Lv, Fa... -  《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(5/6) - e4146~e4146 - 共10页

摘要:Constructing deuterated molecules efficiently |  and practically has been a long-standing challenge | . Deuterated steroid hormones are essential for medical |  research and drug metabolism studies and are thus in high |  demand; mild and selective methods for the deuteration
关键词: H/D exchange; gram‐scale synthesis; microcontinuous; steroid hormones; ultrasound.

8. Evaluation of New-Modelled Recombinant Human Insulin (rh-Insulin) Analog Expressed in E. coli Using Radioiodination Technique Followed by In Vivo Biodistribution in Diabetes-Induced Mice NSTL国家科技图书文献中心

Abdelaziz, Gamal |  Abdelghany, Ibrahim ...... -  《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(1/2) - e4134~e4134 - 共7页

摘要:Biologists have significantly improved various |  techniques for confirming the physiological and |  pharmacological activity of new proteins produced by recombinant |  DNA technology, such as Western blotting, ELISA, and |  flow cytometry. Although these methods are costly and
关键词: I-125-rh-Insulin |  diabetes mellitus |  in vivo biodistribution |  RCY |  125I‐rh‐Insulin

9. Design and Synthesis of a 18 F-Radiolabeled Pyrrolo[2,3- d ]pyrimidine Ligand as a CSF1R Receptor PET Imaging Agent NSTL国家科技图书文献中心

Cherukupalli, Sriniv... |  Karlsen, Morten... -  《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(1/2) - e4131~e4131 - 共8页

摘要:Colony-stimulating factor 1 receptor (CSF1R or |  c-FMS), a class III receptor tyrosine kinase, is |  significantly expressed in mononuclear phagocytes and in the |  central nervous system. It has been identified as a |  potential drug and imaging target in numerous inflammatory
关键词: CSF1R receptor |  fluorine-18 |  pyrrolo[2,3-d]pyrimidine |  radiochemistry |  tosylate leaving group |  fluorine‐18 |  pyrrolo[2,3‐d]pyrimidine

10. Synthesis and Imaging of Novel CDK19-Targeted Tracers Incorporating an Albumin-Binding Moiety NSTL国家科技图书文献中心

Li, Panfeng |  Yang, Zhao... -  《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(3) - e4130~e4130 - 共10页

摘要:Cyclin-dependent kinase 19 (CDK19) is a |  potential target for the diagnosis and treatment of |  prostate cancer. We have previously studied a series of |  CDK19-targeted PET tracers, but in-depth drug |  optimization is needed to improve the physiochemical
关键词: albumin binder |  CDK19 |  PET imaging |  prostate cancer |  radiotraces
检索条件出处:Journal of labelled compounds & radiopharmaceuticals.
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