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1. A four in one nanoplatform: Theranostic bismuth-containing nanoMOFs for chemo-photodynamic- radiation therapy and CT scan imaging NSTL国家科技图书文献中心

Goji, Naeimeh Hassan... | Alibolandi, Mona ... - 《International Journal of Pharmaceutics》 - 2025,668 - 124971～124971 - 共18页

摘要：Integration of different therapeutic | performances into one platform is an innovative development | for using multiple applications in real-time. In | this paper, for the first time we exploited the | concurrent capacity of radio and photosensitizing in a

关键词： Metal-Organic-Frameworks | Multimodal therapy | Chemotherapy | Theranostics | Radiation therapy | Photodynamic therapy | CT imaging | Florescence imaging

2. Reverse engineering of Onivyde® - Irinotecan liposome injection NSTL国家科技图书文献中心

Gan, Jingyao | Juang, Vivian ... - 《International Journal of Pharmaceutics》 - 2025,669 - 125000～125000 - 共11页

摘要：Onivyde (R) is an intravenous irinotecan | liposomal injection approved by the FDA for the treatment | of gemcitabine-refractory metastatic adenocarcinoma | of the pancreas in combination with fluorouracil | and leucovorin. In the Onivyde (R) formulation

关键词： Onivyde (R) | Liposome | Characterization | Quantification | Analytical methods | Drug release

3. Utilising terahertz pulsed imaging to analyse the anhydrous-to-hydrate transformation of excipients during immediate release film coating hydration NSTL国家科技图书文献中心

Ma, Mingrui | Nassar, Marwa ... - 《International Journal of Pharmaceutics》 - 2025,670 - 125119～125119 - 共12页

摘要：Pharmaceutical tablets are routinely film | -coated to improve appearance, reduce medication errors | and enhance storage stability. Terahertz pulsed | imaging (TPI) can be utilised to study the liquid | penetration into the porous tablet matrix in real time

关键词： Tablet | Immediate release | Film coating | Terahertz pulsed imaging | Hydrate | Lactose | Mannitol

4. Rabies virus-mimicking liposomes for targeted gene therapy in Alzheimer's disease NSTL国家科技图书文献中心

Erel-Akbaba, Gulsah | Akbaba, Hasan ... - 《International Journal of Pharmaceutics》 - 2025,668 - 124962～124962 - 共13页

摘要：RNA interference (RNAi) harbors significant | potential for treating neurological disorders | ; nevertheless, limited efficacy has been discerned. The | presence of barriers within the central nervous system | , coupled with the inherent instability of nucleic acids

关键词： siRNA | BACE1 | RVG29 | Virus-mimic liposome | Alzheimer's disease

5. Peptide-based inhibitors and nanoparticles: Emerging therapeutics for Alzheimer's disease NSTL国家科技图书文献中心

Mojarad-Jabali, Solm... | Roh, Kyung-Ho - 《International Journal of Pharmaceutics》 - 2025,669 - 125055～125055 - 共22页

摘要：Alzheimer's disease (AD) is an age-related | progressive neurodegenerative disorder characterized by | memory loss, cognitive decline, and behavioral changes | , impacting millions of individuals worldwide. Despite | significant research into its cellular and molecular

关键词： Alzheimer's disease | Peptide-based inhibitors | Amyloid-(3 | Tau protein | Metal ions | Nanoparticles | Targeted delivery

6. Novel Nose-to-brain delivery of carbenoxolone via mucoadhesive solid lipid nanoparticles for Parkinson's symptoms management: In vitro and in vivo evaluation in a rotenone-induced rat model NSTL国家科技图书文献中心

Nematalla, Hisham A. | Elharoun, Mona ... - 《International Journal of Pharmaceutics》 - 2025,670 - 125197～125197 - 共12页

摘要：Parkinson's disease (PD) is a debilitating | neurodegenerative disorder characterized by motor and non-motor | symptoms, with limited effective treatment options. This | study proposes a novel approach utilizing intranasal | delivery of carbenoxolone (CBX) via chitosan-coated solid

关键词： Brain targeting | Chitosan | Solid Lipid Nanocarriers | Carbenoxolone | Parkinson's disease | Neuroinflammation

7. Tumor specific delivery and radiation-enhanced tumor penetration of mesoporous silica nanoparticles for effective radionuclide therapy of ovarian peritoneal metastasis NSTL国家科技图书文献中心

Hargrove, Derek | Ranjbar, Sheyda ... - 《International Journal of Pharmaceutics》 - 2025,669 - 125071～125071 - 共11页

摘要：Advanced ovarian cancer with peritoneal | metastasis is challenging to treat. Limited tumor delivery | and penetration of the therapeutics to deep tumor | regions are significant barriers to effective treatment | . The rising radiopharmaceuticals offer hopes for

关键词： Ovarian cancer | Peritoneal metastasis | Internal radiation therapy | Intraperitoneal delivery | Holmiun-166 | Neutron activation

8. Impact of route of particle engineering on dissolution performance of posaconazole NSTL国家科技图书文献中心

Xiang, Tianyi | Wang, Zijian ... - 《International Journal of Pharmaceutics》 - 2025,669 - 125025～125025 - 共8页

摘要：Even when they have similar particle size | , micron sized drug crystals prepared via different | process routes may still exhibit considerable | variability in pharmaceutical properties, due to the | anisotropy of molecular crystals. This study aims to

关键词： Posaconazole | Dissolution | Agglomeration | Stability | Micronization

9. Dihydromyricetin/montmorillonite intercalation compounds ameliorates DSS-induced colitis: Role of intestinal epithelial barrier, NLRP3 inflammasome pathway and gut microbiota NSTL国家科技图书文献中心

Jiang, Luxia | Ma, Xueni ... - 《International Journal of Pharmaceutics》 - 2025,670 - 125155～125155 - 共13页

摘要：Dihydromyricetin (DHM), the primary active | compound in vine tea possesses various pharmacological | effects such as anti-inflammatory and antioxidant | properties, along with high biosafety. However, its oral | delivery remains a significant challenge. Montmorillonite

关键词： Dihydromyricetin | Montmorillonite | Ulcerative colitis | Intestinal barrier | NLRP3 | Gut microbiota

10. In vivo pharmacokinetic study and PBPK modeling: Comparison between 3D-printed nanocrystals and solid dispersions NSTL国家科技图书文献中心

Lopez-Vidal, Lucia | Tinti, Mariano ... - 《International Journal of Pharmaceutics》 - 2025,669 - 125063～125063 - 共15页 - 被引量：1

摘要：The solubility of drugs remains one of the | most challenging aspects of formulation development | . Several technologies exist to enhance the properties of | poorly soluble drugs, with nanocrystal (NC) and solid | dispersion (SD) technologies being among the most important

关键词： Albendazole | Pharmacokinetic study | Dogs | Bioequivalence analysis | PBPK model | Parameter Sensitivity Analysis | 3D-printing technology | MESO-PP

摘要：Integration of different therapeutic | performances into one platform is an innovative development | for using multiple applications in real-time. In | this paper, for the first time we exploited the | concurrent capacity of radio and photosensitizing in a

关键词： Metal-Organic-Frameworks | Multimodal therapy | Chemotherapy | Theranostics | Radiation therapy | Photodynamic therapy | CT imaging | Florescence imaging

摘要：Onivyde (R) is an intravenous irinotecan | liposomal injection approved by the FDA for the treatment | of gemcitabine-refractory metastatic adenocarcinoma | of the pancreas in combination with fluorouracil | and leucovorin. In the Onivyde (R) formulation

关键词： Onivyde (R) | Liposome | Characterization | Quantification | Analytical methods | Drug release

摘要：Pharmaceutical tablets are routinely film | -coated to improve appearance, reduce medication errors | and enhance storage stability. Terahertz pulsed | imaging (TPI) can be utilised to study the liquid | penetration into the porous tablet matrix in real time

关键词： Tablet | Immediate release | Film coating | Terahertz pulsed imaging | Hydrate | Lactose | Mannitol

摘要：RNA interference (RNAi) harbors significant | potential for treating neurological disorders | ; nevertheless, limited efficacy has been discerned. The | presence of barriers within the central nervous system | , coupled with the inherent instability of nucleic acids

关键词： siRNA | BACE1 | RVG29 | Virus-mimic liposome | Alzheimer's disease

摘要：Alzheimer's disease (AD) is an age-related | progressive neurodegenerative disorder characterized by | memory loss, cognitive decline, and behavioral changes | , impacting millions of individuals worldwide. Despite | significant research into its cellular and molecular

关键词： Alzheimer's disease | Peptide-based inhibitors | Amyloid-(3 | Tau protein | Metal ions | Nanoparticles | Targeted delivery

摘要：Parkinson's disease (PD) is a debilitating | neurodegenerative disorder characterized by motor and non-motor | symptoms, with limited effective treatment options. This | study proposes a novel approach utilizing intranasal | delivery of carbenoxolone (CBX) via chitosan-coated solid

关键词： Brain targeting | Chitosan | Solid Lipid Nanocarriers | Carbenoxolone | Parkinson's disease | Neuroinflammation

摘要：Advanced ovarian cancer with peritoneal | metastasis is challenging to treat. Limited tumor delivery | and penetration of the therapeutics to deep tumor | regions are significant barriers to effective treatment | . The rising radiopharmaceuticals offer hopes for

关键词： Ovarian cancer | Peritoneal metastasis | Internal radiation therapy | Intraperitoneal delivery | Holmiun-166 | Neutron activation

摘要：Even when they have similar particle size | , micron sized drug crystals prepared via different | process routes may still exhibit considerable | variability in pharmaceutical properties, due to the | anisotropy of molecular crystals. This study aims to

关键词： Posaconazole | Dissolution | Agglomeration | Stability | Micronization

摘要：Dihydromyricetin (DHM), the primary active | compound in vine tea possesses various pharmacological | effects such as anti-inflammatory and antioxidant | properties, along with high biosafety. However, its oral | delivery remains a significant challenge. Montmorillonite

关键词： Dihydromyricetin | Montmorillonite | Ulcerative colitis | Intestinal barrier | NLRP3 | Gut microbiota

摘要：The solubility of drugs remains one of the | most challenging aspects of formulation development | . Several technologies exist to enhance the properties of | poorly soluble drugs, with nanocrystal (NC) and solid | dispersion (SD) technologies being among the most important

关键词： Albendazole | Pharmacokinetic study | Dogs | Bioequivalence analysis | PBPK model | Parameter Sensitivity Analysis | 3D-printing technology | MESO-PP

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