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1. Locally administered nanosuspension increases delivery of estradiol for the treatment of vaginal atrophy in mice NSTL国家科技图书文献中心

Shapiro, Rachel L. | Bethiana, Titania ... - 《Drug delivery and translational research》 - 2025,15(2) - 609～620 - 共12页

摘要：Vaginal atrophy affects up to 57% of post | -menopausal women, with symptoms ranging from vaginal | burning to dysuria. Estradiol hormone replacement | therapy may be prescribed to alleviate these symptoms | , though many vaginal products have drawbacks including

关键词： Vaginal drug delivery | Vaginal atrophy | Estradiol | Nanosuspension | Menopause

2. Amelioration of breast cancer therapies through normalization of tumor vessels and microenvironment: paradigm shift to improve drug perfusion and nanocarrier permeation NSTL国家科技图书文献中心

Famta, Paras | Shah, Saurabh ... - 《Drug delivery and translational research》 - 2025,15(2) - 389～406 - 共18页

摘要：Breast cancer (BC) is the most commonly | diagnosed cancer among women. Chemo-, immune- and | photothermal therapies are employed to manage BC. However | , the tumor microenvironment (TME) prevents free drugs | and nanocarriers (NCs) from entering the tumor

关键词： Angiogenesis | Tumor microenvironment normalization | Mechanotherapeutics | Chemotherapy | Immunotherapy

3. The penetration efficiency of a dissolved model drug into hair follicles depends on the concentration of added nanoparticles NSTL国家科技图书文献中心

Busch, Loris | Asadzadeh, Darya ... - 《Drug delivery and translational research》 - 2025,15(4) - 1444～1452 - 共9页

摘要：Hair follicles have recently emerged as | promising drug delivery targets and gates for skin | penetration. The so-called ratchet effect, which is based on | an interaction between the hair shaft surface, the | intrafollicular stratum corneum and nanoparticles, has proven to

关键词： Confocal laser scanning microscopy | Ratchet effect | Adhesion effect | Skin penetration

4. Exploration of Abiraterone acetate loaded Nanostructured lipid carriers for bioavailability improvement and circumvention of fast-fed variability NSTL国家科技图书文献中心

Shah, Saurabh | Famta, Paras ... - 《Drug delivery and translational research》 - 2025,15(3) - 1074～1091 - 共18页

摘要：Abiraterone acetate (ABA), a biopharmaceutical | class IV drug suffers from solubility and permeability | pitfalls resulting in limited oral bioavailability and | positive food effect, i.e. multi-fold enhancement in drug | absorption in the presence of food. This poses difficulties

关键词： Abiraterone | Nanostructured lipid carriers | Fast-fed variability | Lymphatic uptake

5. 3D printed microneedles: revamping transdermal drug delivery systems NSTL国家科技图书文献中心

Prabhu, Ashlesh | Baliga, Vishal ... - 《Drug delivery and translational research》 - 2025,15(2) - 436～454 - 共19页

摘要：One of the advancements of the transdermal | drug delivery system (TDDS) is the development of | microneedles (MNs). These micron-sized needles are used for | delivering various types of drugs to address the | disadvantage of other transdermal techniques as well as oral

关键词： 3D printing | Microneedles | Transdermal drug delivery systems | Fused deposition modelling | Stereolithography

6. PBPK model of pegylated liposomal doxorubicin to simultaneously predict the concentration-time profile of encapsulated and free doxorubicin in tissues NSTL国家科技图书文献中心

Cao, Xuewei | Li, Kejun ... - 《Drug delivery and translational research》 - 2025,15(4) - 1342～1362 - 共21页

摘要：The objective of this study was to develop a | physiologically based pharmacokinetic (PBPK) model to predict | the concentrations of encapsulated and free | doxorubicin in plasma and tissues in mice after intravenous | injection of PEGylated liposomes (Doxil (R)). The PBPK

关键词： PBPK model | Doxorubicin | Liposome | Distribution | Pharmacokinetics

7. Revolutionizing rheumatoid arthritis therapy: harnessing cytomembrane biomimetic nanoparticles for novel treatment strategies NSTL国家科技图书文献中心

Ma, Lan | Jiang, Xinchi ... - 《Drug delivery and translational research》 - 2025,15(1) - 66～83 - 共18页

摘要：Rheumatoid arthritis (RA) is a systemic immune | disease with severe implications for joint health. The | issue of non-specific drug distribution potentially | limits the therapeutic efficacy and increases the risk | associated with RA treatment. Researchers employed

关键词： Cytomembrane | Biomimetic nanoparticle | Rheumatoid arthritis | Polymer nanoparticle

8. Evodiamine encapsulated by hyaluronic acid modified zeolitic imidazolate framework-8 for tumor targeted therapy NSTL国家科技图书文献中心

Zhou, Qiang | Xie, Dandan ... - 《Drug delivery and translational research》 - 2025,15(3) - 978～991 - 共14页

摘要：Evodiamine (EVO), a natural bioactive compound | extracted from Evodia rutaecarpa, shows therapeutic | ability against malignant melanoma. However, the poor | solubility and bioavailability of EVO limit its clinical | application. Metal-organic frameworks (MOFs) have shown

关键词： Evodiamine | Drug delivery system | Zeolitic imidazolate framework-8 | Hyaluronic acid | Melanoma

9. Brain targeted lactoferrin coated lipid nanocapsules for the combined effects of apocynin and lavender essential oil in PTZ induced seizures NSTL国家科技图书文献中心

Youssef, Julie R. | Boraie, Nabila A.... - 《Drug delivery and translational research》 - 2025,15(2) - 534～555 - 共22页

摘要：Apocynin (APO) is a plant derived antioxidant | exerting specific NADPH oxidase inhibitory action | substantiating its neuroprotective effects in various CNS | disorders, including epilepsy. Due to rapid elimination | and poor bioavailability, treatment with APO is

关键词： NADPH-oxidase inhibitor | Essential oil | Epilepsy | Subcutaneous | Bioavailability | Log BB

10. Manufacturing and characterisation of 3D-printed sustained-release Timolol implants for glaucoma treatment NSTL国家科技图书文献中心

Paleel, Fathima | Qin, Mengqi ... - 《Drug delivery and translational research》 - 2025,15(1) - 242～252 - 共11页

摘要：Timolol maleate (TML) is a beta-blocker drug | that is commonly used to lower the intraocular | pressure in glaucoma. This study focused on using a 3D | printing (3DP) method for the manufacturing of an ocular | , implantable, sustained-release drug delivery system (DDS

摘要：Vaginal atrophy affects up to 57% of post | -menopausal women, with symptoms ranging from vaginal | burning to dysuria. Estradiol hormone replacement | therapy may be prescribed to alleviate these symptoms | , though many vaginal products have drawbacks including

关键词： Vaginal drug delivery | Vaginal atrophy | Estradiol | Nanosuspension | Menopause

摘要：Breast cancer (BC) is the most commonly | diagnosed cancer among women. Chemo-, immune- and | photothermal therapies are employed to manage BC. However | , the tumor microenvironment (TME) prevents free drugs | and nanocarriers (NCs) from entering the tumor

关键词： Angiogenesis | Tumor microenvironment normalization | Mechanotherapeutics | Chemotherapy | Immunotherapy

摘要：Hair follicles have recently emerged as | promising drug delivery targets and gates for skin | penetration. The so-called ratchet effect, which is based on | an interaction between the hair shaft surface, the | intrafollicular stratum corneum and nanoparticles, has proven to

关键词： Confocal laser scanning microscopy | Ratchet effect | Adhesion effect | Skin penetration

摘要：Abiraterone acetate (ABA), a biopharmaceutical | class IV drug suffers from solubility and permeability | pitfalls resulting in limited oral bioavailability and | positive food effect, i.e. multi-fold enhancement in drug | absorption in the presence of food. This poses difficulties

关键词： Abiraterone | Nanostructured lipid carriers | Fast-fed variability | Lymphatic uptake

摘要：One of the advancements of the transdermal | drug delivery system (TDDS) is the development of | microneedles (MNs). These micron-sized needles are used for | delivering various types of drugs to address the | disadvantage of other transdermal techniques as well as oral

关键词： 3D printing | Microneedles | Transdermal drug delivery systems | Fused deposition modelling | Stereolithography

摘要：The objective of this study was to develop a | physiologically based pharmacokinetic (PBPK) model to predict | the concentrations of encapsulated and free | doxorubicin in plasma and tissues in mice after intravenous | injection of PEGylated liposomes (Doxil (R)). The PBPK

关键词： PBPK model | Doxorubicin | Liposome | Distribution | Pharmacokinetics

摘要：Rheumatoid arthritis (RA) is a systemic immune | disease with severe implications for joint health. The | issue of non-specific drug distribution potentially | limits the therapeutic efficacy and increases the risk | associated with RA treatment. Researchers employed

关键词： Cytomembrane | Biomimetic nanoparticle | Rheumatoid arthritis | Polymer nanoparticle

摘要：Evodiamine (EVO), a natural bioactive compound | extracted from Evodia rutaecarpa, shows therapeutic | ability against malignant melanoma. However, the poor | solubility and bioavailability of EVO limit its clinical | application. Metal-organic frameworks (MOFs) have shown

关键词： Evodiamine | Drug delivery system | Zeolitic imidazolate framework-8 | Hyaluronic acid | Melanoma

摘要：Apocynin (APO) is a plant derived antioxidant | exerting specific NADPH oxidase inhibitory action | substantiating its neuroprotective effects in various CNS | disorders, including epilepsy. Due to rapid elimination | and poor bioavailability, treatment with APO is

关键词： NADPH-oxidase inhibitor | Essential oil | Epilepsy | Subcutaneous | Bioavailability | Log BB

摘要：Timolol maleate (TML) is a beta-blocker drug | that is commonly used to lower the intraocular | pressure in glaucoma. This study focused on using a 3D | printing (3DP) method for the manufacturing of an ocular | , implantable, sustained-release drug delivery system (DDS

关键词： Glaucoma | Timolol | 3D printing | Drug-eluting implants | Sustained-release

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