NSTL国家科技图书文献中心

1. Development and optimization of an mRNA-vectored single-chain IgA1 isotype monoclonal antibody with potential to treat or prevent dengue virus infection NSTL国家科技图书文献中心

Nguyen, Thanh | Gebo, Chad ... - 《Antiviral Research》 - 2025,234 - 106078～106078 - 共6页

摘要：Dengue virus (DENV) is a rapidly expanding | infectious disease threat that causes an estimated 100 | million symptomatic infections every year. A barrier to | preventing DENV infections with traditional vaccines or | prophylactic monoclonal antibody (mAb) therapies is the

关键词： Monoclonal antibody | Lipid nanoparticle | Dengue virus | Single chain | mRNA

2. "Insights in the RSV L polymerase function and structure" NSTL国家科技图书文献中心

Bonneux, Brecht | Ceconi, Martina ... - 《Antiviral Research》 - 2025,237 - Article 106148～Article 106148 - 共11页

摘要：Respiratory syncytial virus (RSV) continues to | have a large medical and economic impact worldwide | , mainly in infants, elderly, and immunocompromised | patients. While several vaccines and prophylactic | antibodies are now available, effective treatment options

关键词： Respiratory syncytial virus | RSV polymerase | AlphaFold3 modeling | Cryo-EM structure

3. Pellino-1, a therapeutic target for control of SARS-CoV-2 infection and disease severity NSTL国家科技图书文献中心

Wang, Binbin | Xia, Hongjie ... - 《Antiviral Research》 - 2025,233 - 106059～106059 - 共11页

摘要：Enhanced expression of Pellino-1 (Peli1), a | ubiquitin ligase is known to be associated with COVID-19 | susceptibility. The underlying mechanisms are not known. Here | , we report that mice deficient in Peli1 (Peli1 | -/-) had reduced viral load and attenuated inflammatory

关键词： Peli1 | SARS-CoV-2 | Pathogenesis | Therapeutic | Inflammation

4. Truncated rotavirus VP4 proteins induce stronger protective immunity compared to P2-VP8 in animal models NSTL国家科技图书文献中心

Chen, Yaling | Luo, Guoxing ... - 《Antiviral Research》 - 2025,238 - Article 106156～Article 106156 - 共9页

摘要：Group A rotavirus (RVA) is the primary | causative agent of acute gastroenteritis (AGE) in children | under five years of age, resulting in over 120,000 | deaths annually. In previous studies, we identified | truncated VP4 as a potentially more promising vaccine*

关键词： Rotavirus | Candidate vaccine | P2-VP8 | Protection | Neutralizing antibodies

5. Antiviral effect of pinostrobin, a bioactive constituent of Boesenbergia rotunda, against porcine epidemic diarrhea virus NSTL国家科技图书文献中心

Chutiwitoonchai, Nop... | Akkarawongsapat, Rad...... - 《Antiviral Research》 - 2025,234 - 106073～106073 - 共12页

摘要：Global swine industry has long been severely | affected by the periodic outbreaks of porcine epidemic | diarrhea (PED), a deadly infectious disease in piglets | caused by the porcine epidemic diarrhea virus (PEDV | ). Currently, available vaccines and antiviral drugs could

关键词： Boesenbergia rotunda extract | Pinostrobin | Porcine epidemic diarrhea virus | Antiviral

6. Overview on the management of herpes simplex virus infections: Current therapies and future directions NSTL国家科技图书文献中心

Alexander Birkmann | Rob Saunders - 《Antiviral Research》 - 2025,237 - Article 106152～Article 106152 - 共9页

摘要：Introduction: Herpes simplex virus type 1 (HSV | -1) and type 2 (HSV-2) are highly prevalent | , infecting approximately 64 % and 13 % of the world's | population, respectively. Traditionally, HSV-1 has been | associated with orofacial infections and HSV-2 with

关键词： Antiviral therapy; Gene therapy; Helicase primase inhibitors; Herpes simplex virus

7. Novel reporter constructs to accelerate antiviral and therapeutic discovery for Enterovirus-A71 NSTL国家科技图书文献中心

Bakhache, William | Shen, Ann ... - 《Antiviral Research》 - 2025,235 - 106094～106094 - 共9页

摘要：Enterovirus A71 (EV-A71) is an important human | pathogen and 'prototype pathogen' for studies of other | Enteroviruses of pandemic potential. Understanding the biology | of EV-A71 would inform generalizable strategies for | antiviral drug, vaccine, and monoclonal antibody

关键词： Enterovirus | Picornavirus | Reporter | Synthetic biology | Luminescent | Fluorescent | de novo protein design

8. CVA16 infection causes neurological injury by engaging TLR2/MYD88/ TNF-α/CXCL1 signalling pathway in hSCARB2 knock-in mice NSTL国家科技图书文献中心

Wang, Yu | Wu, Yong ... - 《Antiviral Research》 - 2025,237 - Article 106133～Article 106133 - 共11页

摘要：Coxsackievirus A16 (CVA16), a major pathogen | responsible for hand-foot-and-mouth disease (HFMD) in | children, has frequently replaced Enterovirus A71 as the | predominant causative agent in China and other Asia-Pacific | regions. The lack effective drugs and vaccines against

关键词： Coxsackievirus A16 | hSCARB2 mice | Nerve injury | TLR2/MYD88/TNF-alpha/Cxcl1 signaling pathway

9. Mechanisms of action of repurposed Ebola virus antivirals - the roles of phospholipidosis and cholesterol homeostasis NSTL国家科技图书文献中心

Kelly, Jamie A. | Aida-Ficken, Virgini...... - 《Antiviral Research》 - 2025,238 - Article 106167～Article 106167 - 共12页

摘要：Cell-based drug repurposing screens have been | a common approach to identifying compounds with | antiviral properties. For Ebola virus (EBOV), such screens | yield unexpectedly high hit rates. We investigated two | mechanisms underlying the anti-EBOV activities of

关键词： Ebola | Phospholipidosis | Antiviral | Cholesterol biosynthesis

10. Research progress of vimentin in viral infections NSTL国家科技图书文献中心

Zheng, Jiawei | Li, Xue ... - 《Antiviral Research》 - 2025,236 - 106121～106121 - 共10页

摘要：Vimentin, a type III intermediate filament | protein, has become a focal point in the research of | viral infections. It participates in multiple crucial | processes during the viral life cycle and the host's | antiviral response. During viral entry, it may function as

摘要：Dengue virus (DENV) is a rapidly expanding | infectious disease threat that causes an estimated 100 | million symptomatic infections every year. A barrier to | preventing DENV infections with traditional vaccines or | prophylactic monoclonal antibody (mAb) therapies is the

关键词： Monoclonal antibody | Lipid nanoparticle | Dengue virus | Single chain | mRNA

摘要：Respiratory syncytial virus (RSV) continues to | have a large medical and economic impact worldwide | , mainly in infants, elderly, and immunocompromised | patients. While several vaccines and prophylactic | antibodies are now available, effective treatment options

关键词： Respiratory syncytial virus | RSV polymerase | AlphaFold3 modeling | Cryo-EM structure

摘要：Enhanced expression of Pellino-1 (Peli1), a | ubiquitin ligase is known to be associated with COVID-19 | susceptibility. The underlying mechanisms are not known. Here | , we report that mice deficient in Peli1 (Peli1 | -/-) had reduced viral load and attenuated inflammatory

关键词： Peli1 | SARS-CoV-2 | Pathogenesis | Therapeutic | Inflammation

摘要：Group A rotavirus (RVA) is the primary | causative agent of acute gastroenteritis (AGE) in children | under five years of age, resulting in over 120,000 | deaths annually. In previous studies, we identified | truncated VP4 as a potentially more promising vaccine*

关键词： Rotavirus | Candidate vaccine | P2-VP8 | Protection | Neutralizing antibodies

摘要：Global swine industry has long been severely | affected by the periodic outbreaks of porcine epidemic | diarrhea (PED), a deadly infectious disease in piglets | caused by the porcine epidemic diarrhea virus (PEDV | ). Currently, available vaccines and antiviral drugs could

关键词： Boesenbergia rotunda extract | Pinostrobin | Porcine epidemic diarrhea virus | Antiviral

摘要：Introduction: Herpes simplex virus type 1 (HSV | -1) and type 2 (HSV-2) are highly prevalent | , infecting approximately 64 % and 13 % of the world's | population, respectively. Traditionally, HSV-1 has been | associated with orofacial infections and HSV-2 with

关键词： Antiviral therapy; Gene therapy; Helicase primase inhibitors; Herpes simplex virus

摘要：Enterovirus A71 (EV-A71) is an important human | pathogen and 'prototype pathogen' for studies of other | Enteroviruses of pandemic potential. Understanding the biology | of EV-A71 would inform generalizable strategies for | antiviral drug, vaccine, and monoclonal antibody

关键词： Enterovirus | Picornavirus | Reporter | Synthetic biology | Luminescent | Fluorescent | de novo protein design

摘要：Coxsackievirus A16 (CVA16), a major pathogen | responsible for hand-foot-and-mouth disease (HFMD) in | children, has frequently replaced Enterovirus A71 as the | predominant causative agent in China and other Asia-Pacific | regions. The lack effective drugs and vaccines against

关键词： Coxsackievirus A16 | hSCARB2 mice | Nerve injury | TLR2/MYD88/TNF-alpha/Cxcl1 signaling pathway

摘要：Cell-based drug repurposing screens have been | a common approach to identifying compounds with | antiviral properties. For Ebola virus (EBOV), such screens | yield unexpectedly high hit rates. We investigated two | mechanisms underlying the anti-EBOV activities of

关键词： Ebola | Phospholipidosis | Antiviral | Cholesterol biosynthesis

摘要：Vimentin, a type III intermediate filament | protein, has become a focal point in the research of | viral infections. It participates in multiple crucial | processes during the viral life cycle and the host's | antiviral response. During viral entry, it may function as

关键词： Vimentin | Viral infections | Immune response

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：Dengue virus (DENV) is a rapidly expanding | infectious disease threat that causes an estimated 100 | million symptomatic infections every year. A barrier to | preventing DENV infections with traditional vaccines or | prophylactic monoclonal antibody (mAb) therapies is the

关键词： Monoclonal antibody | Lipid nanoparticle | Dengue virus | Single chain | mRNA

摘要：Respiratory syncytial virus (RSV) continues to | have a large medical and economic impact worldwide | , mainly in infants, elderly, and immunocompromised | patients. While several vaccines and prophylactic | antibodies are now available, effective treatment options

关键词： Respiratory syncytial virus | RSV polymerase | AlphaFold3 modeling | Cryo-EM structure

摘要：Enhanced expression of Pellino-1 (Peli1), a | ubiquitin ligase is known to be associated with COVID-19 | susceptibility. The underlying mechanisms are not known. Here | , we report that mice deficient in Peli1 (Peli1 | -/-) had reduced viral load and attenuated inflammatory

关键词： Peli1 | SARS-CoV-2 | Pathogenesis | Therapeutic | Inflammation

摘要：Group A rotavirus (RVA) is the primary | causative agent of acute gastroenteritis (AGE) in children | under five years of age, resulting in over 120,000 | deaths annually. In previous studies, we identified | truncated VP4* as a potentially more promising vaccine

关键词： Rotavirus | Candidate vaccine | P2-VP8 | Protection | Neutralizing antibodies

摘要：Global swine industry has long been severely | affected by the periodic outbreaks of porcine epidemic | diarrhea (PED), a deadly infectious disease in piglets | caused by the porcine epidemic diarrhea virus (PEDV | ). Currently, available vaccines and antiviral drugs could

关键词： Boesenbergia rotunda extract | Pinostrobin | Porcine epidemic diarrhea virus | Antiviral

摘要：Introduction: Herpes simplex virus type 1 (HSV | -1) and type 2 (HSV-2) are highly prevalent | , infecting approximately 64 % and 13 % of the world's | population, respectively. Traditionally, HSV-1 has been | associated with orofacial infections and HSV-2 with

关键词： Antiviral therapy; Gene therapy; Helicase primase inhibitors; Herpes simplex virus

摘要：Enterovirus A71 (EV-A71) is an important human | pathogen and 'prototype pathogen' for studies of other | Enteroviruses of pandemic potential. Understanding the biology | of EV-A71 would inform generalizable strategies for | antiviral drug, vaccine, and monoclonal antibody

关键词： Enterovirus | Picornavirus | Reporter | Synthetic biology | Luminescent | Fluorescent | de novo protein design

摘要：Coxsackievirus A16 (CVA16), a major pathogen | responsible for hand-foot-and-mouth disease (HFMD) in | children, has frequently replaced Enterovirus A71 as the | predominant causative agent in China and other Asia-Pacific | regions. The lack effective drugs and vaccines against

关键词： Coxsackievirus A16 | hSCARB2 mice | Nerve injury | TLR2/MYD88/TNF-alpha/Cxcl1 signaling pathway

摘要：Cell-based drug repurposing screens have been | a common approach to identifying compounds with | antiviral properties. For Ebola virus (EBOV), such screens | yield unexpectedly high hit rates. We investigated two | mechanisms underlying the anti-EBOV activities of

关键词： Ebola | Phospholipidosis | Antiviral | Cholesterol biosynthesis

摘要：Vimentin, a type III intermediate filament | protein, has become a focal point in the research of | viral infections. It participates in multiple crucial | processes during the viral life cycle and the host's | antiviral response. During viral entry, it may function as

关键词： Vimentin | Viral infections | Immune response

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：Group A rotavirus (RVA) is the primary | causative agent of acute gastroenteritis (AGE) in children | under five years of age, resulting in over 120,000 | deaths annually. In previous studies, we identified | truncated VP4 as a potentially more promising vaccine*