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1. Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity NSTL国家科技图书文献中心

Wiederhold, Nathan P... | Patterson, Hoja P.... - 《Antimicrobial agents and chemotherapy.》 - 2025,69(1) - e0098824～e0098824 - 共5页

摘要：We evaluated the in vitro activity of olorofim | against Coccidioides species. Olorofim demonstrated | potent in vitro activity against all isolates tested | with a minimum inhibitory concentration (MIC) range | <= 0.008-0.06 mu g/mL and geometric mean MIC of 0.010 mu

关键词： olorofim | Coccidioides species | in vitro susceptibility | fluconazole

2. The microbiome-restorative potential of ibezapolstat for the treatment of Clostridioides difficile infection is predicted through variant PolC-type DNA polymerase III in Lachnospiraceae and Oscillospiraceae NSTL国家科技图书文献中心

Mcpherson, Jacob K. | Hurdle, Julian G.... - 《Antimicrobial agents and chemotherapy.》 - 2025,69(4) - e0167924～e0167924 - 共9页

摘要：Ibezapolstat (IBZ), a first-in-class | antibiotic targeting the PolC-type DNA polymerase III alpha | -subunit (PolC) in low G + C bacteria, is in clinical | development for the treatment of Clostridioides difficile | infection (CDI). In the phase 2 trials, IBZ had potent

关键词： DNA replication | PolC-type DNA polymerase III | Bacillota | Clostridioides difficile | Lachnospiraceae | Oscillospiraceae | ibezapolstat

3. Restoring cefepime activity against multidrug-resistant KPC-producing Klebsiella pneumoniae by combination with boronic acid inhibitors, MB076 and S02030 NSTL国家科技图书文献中心

Rojas, Laura J. | Nielsen, Travis B.... - 《Antimicrobial agents and chemotherapy.》 - 2025,69(3) - e0096424～e0096424 - 共13页

摘要：Foremost in the design of new beta-lactamase | inhibitors (BLIs) are the boronic acid transition state | inhibitors (BATSIs). Two highly potent BATSIs being | developed are S02030 and MB076 strategically designed to | be active against cephalosporinases and

关键词： BATSI | beta-lactamases | beta-lactamase inhibitor | KPC | MB076 | S02030 | cefepime | boronic acid inhibitor

4. Pharmacokinetics, tolerability, and safety of TBI-223, a novel oxazolidinone, in healthy participants NSTL国家科技图书文献中心

Lombardi, Antonio | Pappas, Fran ... - 《Antimicrobial agents and chemotherapy.》 - 2025,69(4) - e0154224～e0154224 - 共17页

摘要：TBI-223 is an oxazolidinone antibiotic under | clinical development for the treatment of tuberculosis | . Preclinical data indicate potent antituberculosis activity | and a potentially improved safety profile over | linezolid. In a single-ascending dose study and a multiple

关键词： TBI-223 | oxazolidinone | tuberculosis | pharmacokinetics | phase 1 | antimicrobial safety

5. How accurate is ceftriaxone at predicting susceptibility of enterobacterales isolates to oral higher-generation cephalosporins? NSTL国家科技图书文献中心

Claeys, Kimberly C. | Simner, Patricia J.... - 《Antimicrobial agents and chemotherapy.》 - 2025,69(2) - e0138724～e0138724 - 共6页

摘要：The reliability of ceftriaxone for inferring | susceptibility to higher-generation oral cephalosporins is | unknown. Overall, ceftriaxone susceptibility predicted | susceptibility to cefuroxime (89%), cefdinir (86%), cefpodoxime | (90%), and cefixime (94%) based on disk diffusion

关键词： ceftriaxone | cefdinir | cefpodoxime | cefixime | cefuroxime

6. Inhibitory effect of copper chelators on the budding in Candida albicans NSTL国家科技图书文献中心

Futamura, Yushi | Yamamoto, Kai ... - 《Antimicrobial agents and chemotherapy.》 - 2025,69(5) - e0003325～e0003325 - 共15页

摘要：Candida albicans exhibits a unique dimorphic | behavior, allowing it to switch between unicellular | budding yeast and filamentous hyphal growth. This | dimorphism is crucial for its pathogenicity, influencing | processes such as adhesion, invasion, immune evasion, and

关键词： Candida albicans | copper chelators | dimorphism | metal homeostasis | natural product screening

7. Efficacy and safety of switching from entecavir to tenofovir alafenamide in chronic hepatitis B patients with low-level viremia: a real-world 48-week extension study NSTL国家科技图书文献中心

He, Meng-Wen | Cui, Li ... - 《Antimicrobial agents and chemotherapy.》 - 2025,69(3) - e0182724～e0182724 - 共15页

摘要：Chronic hepatitis B (CHB) patients receiving | entecavir (ETV) treatment might develop low-level viremia | (LLV), which is proven to be associated with worse | clinical outcomes, such as risk of drug-related mutations | , progression to cirrhosis, and even hepatocellular carcinoma

关键词： low-level viremia | chronic hepatitis B | complete virological response | ALT normalization | lipid effect | renal safety

8. Stage-specific pharmacodynamic chloroquine and pyronaridine action on artemisinin ring-stage resistant Kelch C580Y mutation Plasmodium falciparum correlates to hemozoin inhibition process NSTL国家科技图书文献中心

Sayeed, Abeer | Atkinson, Revie ... - 《Antimicrobial agents and chemotherapy.》 - 2025,69(1) - e0120824～e0120824 - 共12页

摘要：The antimalarial quinolines pyronaridine and | chloroquine both inhibit hemozoin crystallization | , predominately produced by Plasmodium falciparum | intraerythrocytic trophozoite stage parasites. Pyronaridine | extends activity to ring-stage chloroquine-sensitive

关键词： hemozoin | chloroquine | pyronaridine | artemisinin | drug resistance

9. Harnessing the effect of iron deprivation to attenuate the growth of opportunistic pathogen Acinetobacter baumannii NSTL国家科技图书文献中心

Saha, Sujata | Roychowdhury, Debasr...... - 《Antimicrobial agents and chemotherapy.》 - 2025,69(5) - e0168924～e0168924 - 共16页

摘要：Acinetobacter baumannii is an opportunistic | pathogen having high infectivity among immunocompromised | patients. The bacteria are resistant to major first-line | antibiotics and have become a serious concern in the aspect | of nosocomial and community-acquired infections. To

关键词： Acinetobacter baumannii | multidrug resistance | beta-Thujaplicin | iron chelator

10. Combination therapy delays antimicrobial resistance after adaptive laboratory evolution of Staphylococcus aureus NSTL国家科技图书文献中心

Petersen, Maiken Eng... | Khamas, Amanda Batou...... - 《Antimicrobial agents and chemotherapy.》 - 2025,69(4) - e0148324～e0148324 - 共18页

摘要：Antibiotic resistance, driven by misuse and | overuse of antibiotics, is one of the greatest threats | against human health. The antimicrobial pressure during | prolonged antibiotic treatment of chronic bacterial | infections selects for resistance. While antibiotic

摘要：We evaluated the in vitro activity of olorofim | against Coccidioides species. Olorofim demonstrated | potent in vitro activity against all isolates tested | with a minimum inhibitory concentration (MIC) range | <= 0.008-0.06 mu g/mL and geometric mean MIC of 0.010 mu

关键词： olorofim | Coccidioides species | in vitro susceptibility | fluconazole

摘要：Ibezapolstat (IBZ), a first-in-class | antibiotic targeting the PolC-type DNA polymerase III alpha | -subunit (PolC) in low G + C bacteria, is in clinical | development for the treatment of Clostridioides difficile | infection (CDI). In the phase 2 trials, IBZ had potent

关键词： DNA replication | PolC-type DNA polymerase III | Bacillota | Clostridioides difficile | Lachnospiraceae | Oscillospiraceae | ibezapolstat

摘要：Foremost in the design of new beta-lactamase | inhibitors (BLIs) are the boronic acid transition state | inhibitors (BATSIs). Two highly potent BATSIs being | developed are S02030 and MB076 strategically designed to | be active against cephalosporinases and

关键词： BATSI | beta-lactamases | beta-lactamase inhibitor | KPC | MB076 | S02030 | cefepime | boronic acid inhibitor

摘要：TBI-223 is an oxazolidinone antibiotic under | clinical development for the treatment of tuberculosis | . Preclinical data indicate potent antituberculosis activity | and a potentially improved safety profile over | linezolid. In a single-ascending dose study and a multiple

关键词： TBI-223 | oxazolidinone | tuberculosis | pharmacokinetics | phase 1 | antimicrobial safety

摘要：The reliability of ceftriaxone for inferring | susceptibility to higher-generation oral cephalosporins is | unknown. Overall, ceftriaxone susceptibility predicted | susceptibility to cefuroxime (89%), cefdinir (86%), cefpodoxime | (90%), and cefixime (94%) based on disk diffusion

关键词： ceftriaxone | cefdinir | cefpodoxime | cefixime | cefuroxime

摘要：Candida albicans exhibits a unique dimorphic | behavior, allowing it to switch between unicellular | budding yeast and filamentous hyphal growth. This | dimorphism is crucial for its pathogenicity, influencing | processes such as adhesion, invasion, immune evasion, and

关键词： Candida albicans | copper chelators | dimorphism | metal homeostasis | natural product screening

摘要：Chronic hepatitis B (CHB) patients receiving | entecavir (ETV) treatment might develop low-level viremia | (LLV), which is proven to be associated with worse | clinical outcomes, such as risk of drug-related mutations | , progression to cirrhosis, and even hepatocellular carcinoma

关键词： low-level viremia | chronic hepatitis B | complete virological response | ALT normalization | lipid effect | renal safety

摘要：The antimalarial quinolines pyronaridine and | chloroquine both inhibit hemozoin crystallization | , predominately produced by Plasmodium falciparum | intraerythrocytic trophozoite stage parasites. Pyronaridine | extends activity to ring-stage chloroquine-sensitive

关键词： hemozoin | chloroquine | pyronaridine | artemisinin | drug resistance

摘要：Acinetobacter baumannii is an opportunistic | pathogen having high infectivity among immunocompromised | patients. The bacteria are resistant to major first-line | antibiotics and have become a serious concern in the aspect | of nosocomial and community-acquired infections. To

关键词： Acinetobacter baumannii | multidrug resistance | beta-Thujaplicin | iron chelator

摘要：Antibiotic resistance, driven by misuse and | overuse of antibiotics, is one of the greatest threats | against human health. The antimicrobial pressure during | prolonged antibiotic treatment of chronic bacterial | infections selects for resistance. While antibiotic

关键词： AMR | Staphylococcus aureus | antibiotic resistance | adaptive mutations

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