NSTL国家科技图书文献中心

1. Prolonged mitosis: A key indicator for detecting stressed and damaged cells NSTL国家科技图书文献中心

Sparr, Carmen | Meitinger, Franz - 《Current Opinion in Cell Biology》 - 2025,92 - 102449～102449 - 共9页

摘要：During mitosis, chromosomes condense, align to | form a metaphase plate and segregate to the two | daughter cells. Mitosis is one of the most complex | recurring transformations in the life of a cell and | requires a high degree of reliability to ensure the error

关键词： Prolonged mitosis | Mitotic surveillance | Mitotic stopwatch | 53BP1 | USP28 | p53 | Mitotic quality control | Genome stability | Cell integrity | Microcephaly...

2. Design principles of regulatory networks underlying epithelial mesenchymal plasticity in cancer cells NSTL国家科技图书文献中心

Sahoo S. | Hari K.... - 《Current Opinion in Cell Biology》 - 2025,92 - 102445～102445 - 共8页

摘要：© 2024 Elsevier LtdPhenotypic plasticity is a | hallmark of cancer and drives metastatic disease and drug | resistance. The dynamics of epithelial mesenchymal | plasticity is driven by complex interactions involving | multiple feedback loops in underlying networks operating

关键词： Attractor | Epigenetic memory | Epithelial-Mesenchymal Transition | Multistability | Phenotypic plasticity

3. Topological epigenetics: The biophysics of DNA supercoiling and its relation to transcription and genome instability NSTL国家科技图书文献中心

Gilbert, Nick | Marenduzzo, Davide - 《Current Opinion in Cell Biology》 - 2025,92 - 102448～102448 - 共11页

摘要：Whilst DNA encodes our genetic blueprint as | individual nucleobases, as well as epigenetic annotations | in the form of biochemical marks, it also carries | an extra layer of topological information -, the | local over or underwinding of the double helix, known

关键词： Supercoiling | chromatin | transcription | chromosome instability | common fragile sites

4. Cell competition and the regulation of protein homeostasis NSTL国家科技图书文献中心

Shruthi Krishnan | Pranab K. Paul ... - 《Current Opinion in Cell Biology》 - 2024,87 - 102323～102323 - 共6页

摘要：The process of embryonic development involves | remarkable cellular plasticity, which governs the | coordination between cells necessary to build an organism | . One role of this plasticity is to ensure that when | aberrant cells are eliminated, growth adjustment occurs

关键词： Cell competition | Mitochondrial dysregulation | Proteostasis | Cell fitness | Winners | Losers.

5. Molecular architecture of the actin cytoskeleton: From single cells to whole organisms using cryo-electron tomography NSTL国家科技图书文献中心

Jonathan Schneider | Marion Jasnin - 《Current Opinion in Cell Biology》 - 2024,88 - 102356～102356 - 共1页

摘要：Cryo-electron tomography (cryo-ET) has | begun to provide intricate views of cellular | architecture at unprecedented resolutions. Considerable | efforts are being made to further optimize and automate | the cryo-ET workflow, from sample preparation to

关键词： Actin filaments | Automation | Cryo-electron tomography | Deep learning-based data analysis | Lift-out | Molecular sociology | Tomogram acquisition.

6. Vertex remodeling during epithelial morphogenesis NSTL国家科技图书文献中心

Sugimura, Kaoru | Otani, Tetsuhisa - 《Current Opinion in Cell Biology》 - 2024,91 - 102427～102427 - 共10页

摘要：Epithelial cells adhere to each other via | intercellular junctions that can be classified into bicellular | junctions and tricellular rearrangement and requires | remodeling of bicellular junctions and vertices. Although | our understanding of how bicellular junction

关键词： Tricellular junction | Cell adhesion | Mechanics | Epithelium

7. Phosphatidylinositol 3,4-bisphosphate: Out of the shadows and into the spotlight NSTL国家科技图书文献中心

Jayatee Ray | David G Sapp ... - 《Current Opinion in Cell Biology》 - 2024,88 - 102372～102372 - 共1页 - 被引量：1

摘要：Phosphoinositide 3-kinases regulate many | cellular functions, including migration, growth | , proliferation, and cell survival. Early studies equated the | inhibition of Class I PI3Ks with loss of | ; phosphatidylinositol 3,4,5-trisphosphate (PIP3), but over time, it

关键词： AKT | PI(3 | 4)P(2) | Phosphoinositides | Signal transduction | endocytosis | mTOR | migration.

8. Forced back into shape: Mechanics of epithelial wound repair NSTL国家科技图书文献中心

Shu En Lim | Pablo Vicente-Munuer...... - 《Current Opinion in Cell Biology》 - 2024,87 - 102324～102324 - 共6页 - 被引量：1

摘要：Wound repair, the closing of a hole, is | inherently a physical process that requires the change of | shape of materials, in this case, cells and tissues | . Not only is efficient and accurate wound repair | critical for restoring barrier function and reducing

关键词： Tissue repair | Wound healing | Mechanics.

9. Spatial patterning of energy metabolism during tissue morphogenesis NSTL国家科技图书文献中心

Lemma, Bezia | Nelson, Celeste M. - 《Current Opinion in Cell Biology》 - 2023,85 - ARTN 102235～ - 共7页

摘要：Biophysical signaling organizes forces to | drive tissue morphogenesis, a process co-opted during | disease progression. The systematic buildup of forces at | the tissue scale is energetically demanding. Just as | mechanical forces, gene expression, and concentrations of

关键词： ATP HYDROLYSIS | MIGRATION | PRINCIPLES | GRADIENT

10. Endosome biogenesis is controlled by ER and the cytoskeleton at tripartite junctions NSTL国家科技图书文献中心

Striepen, Jonathan F... | Voeltz, Gia K. - 《Current Opinion in Cell Biology》 - 2023,80 - ARTN 102155～ - 共8页 - 被引量：8

摘要：The plasma membrane (PM) and its associated | cargo are internalized into small vesicles via | endocytosis funneling cargo into endosomes. The endosomal | system must efficiently deliver cargos, as well as | recycle cargo receptors and mem-brane to maintain