NSTL国家科技图书文献中心

1. Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells NSTL国家科技图书文献中心

Sun, Jiandong | Lian, Xiuli ... - 《Cell Biology and Toxicology》 - 2023,39(6) - 3141～3157 - 共17页 - 被引量：1

摘要：Infertility has attracted global concern, and | disruption of testosterone is a common cause of male | infertility. Exploring the critical factors in testosterone | biosynthesis may provide new insights for disease research | and clinical therapy. Research on

关键词： Trichorhinophalangeal syndrome-1 gene | Leydig cells | Steroidogenesis | Histone acetylation | Adeno-associated virus | Conditional knockout models | SPERMATOGONIAL STEM-CELLS | INHIBITOR TRICHOSTATIN-A | MALE-INFERTILITY | TESTICULAR DYSFUNCTION...

2. CCL24 / CCR3 axis plays a central role in angiotensin II-induced heart failure by stimulating M2 macrophage polarization and fibroblast activation NSTL国家科技图书文献中心

Wang, Zhen | Xu, Hongfei ... - 《Cell Biology and Toxicology》 - 2023,39(4) - 1413～1431 - 共19页 - 被引量：7

摘要：Aims We aimed to investigate the effect and | mechanism of pleiotropic chemokine CCL24 in heart failure | . Methods and results Compared with normal donators, the | expression of CCL24 and number of cardiac M2 macrophages in | heart were higher in heart failure patients, the same

关键词： Heart failure | CCL24 | M2 macrophage | Cardiac fibroblast | CXC-CHEMOKINES | EXPRESSION | REPAIR | CONFERS | INJURY | CCR3

3. Tumor-derived exosomes orchestrate the microRNA-128-3p/ELF4/CDX2 axis to facilitate the growth and metastasis of gastric cancer via delivery of LINC01091 NSTL国家科技图书文献中心

Wang, Qiang | Zhang, Chunmei ... - 《Cell Biology and Toxicology》 - 2023,39(2) - 519～536 - 共18页 - 被引量：8

摘要：It has been manifested that tumor-derived | exosomes (Exos) can deliver long noncoding RNAs to | participate in gastric cancer (GC) progression. In this | research, we intended to dissect out whether tumor | -derived Exos carried LINC01091 to afflict the growth and

关键词： Gastric cancer | Tumor-derived exosomes | LINC01091 | MicroRNA-128-3p | ELF4 | CDX2 | Growth | Metastasis | PROMOTES STEMNESS | RESISTANCE...

4. Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK NSTL国家科技图书文献中心

Xu, Yujie | Xu, Haozhe ... - 《Cell Biology and Toxicology》 - 2023,39(6) - 2709～2724 - 共16页

摘要：Drug-induced liver injury (DILI) still poses a | major clinical challenge and is a leading cause of | acute liver failure. Inhibitor of nuclear factor kappa | B kinase subunit epsilon (IKBKE) is essential for | inflammation and metabolic disorders. However, it is unclear

关键词： IKBKE | RIPK1 | JNK | Acetaminophen | Liver injury | INDUCED LIVER-INJURY | TERMINAL KINASE | CELL-DEATH | APOPTOSIS | PHOSPHORYLATION...

5. Syringaresinol protects against diabetic nephropathy by inhibiting pyroptosis via NRF2-mediated antioxidant pathway NSTL国家科技图书文献中心

Li, Guangru | Liu, Chang ... - 《Cell Biology and Toxicology》 - 2023,39(3) - 621～639 - 共19页 - 被引量：8

摘要：Diabetic nephropathy (DN) is one of the | serious complications of diabetes that has limited | treatment options. As a lytic inflammatory cell death | , pyroptosis plays an important role in the pathogenesis of | DN. Syringaresinol (SYR) possesses anti

关键词： Diabetic nephropathy | Syringaresinol | Pyroptosis | Oxidative stress | INDUCED NLRP3 INFLAMMASOME | CELLS

6. Early transcriptomic signatures and biomarkers of renal damage due to prolonged exposure to embedded metal NSTL国家科技图书文献中心

Wen, Yuan | Vechetti, Ivan J.... - 《Cell Biology and Toxicology》 - 2023,39(6) - 2861～2880 - 共20页 - 被引量：2

摘要：Background Prolonged exposure to toxic heavy | metals leads to deleterious health outcomes including | kidney injury. Metal exposure occurs through both | environmental pathways including contamination of drinking | water sources and from occupational hazards, including

关键词： Renal toxicity | High-throughput transcriptomics | Embedded metal | Mitochondria | DEPLETED URANIUM | OXIDATIVE STRESS | MOLECULE-1 KIM-1 | TREFOIL FACTOR-3 | KIDNEY INJURY | LEAD...

7. Transcriptional activation of budding yeast DDI2 / 3 through chemical modifications of Fzf1 NSTL国家科技图书文献中心

Lin, Aiyang | Chumala, Paulos ... - 《Cell Biology and Toxicology》 - 2023,39(4) - 1531～1547 - 共17页

摘要：DDI2 and DDI3 (DDI2/3) are two identical genes | in Saccharomyces cerevisiae encoding cyanamide (CY | ) hydratase. They are not only highly induced by CY, but | also by a DNA-damaging agent methyl methanesulfonate | (MMS), and the regulatory mechanism is unknown. In

关键词： Saccharomyces cerevisiae | DDI2/3 | Transcriptional regulation | Fzf1 | Cyanamide | Methylation | INDUCED GENE-EXPRESSION | SACCHAROMYCES-CEREVISIAE | DAMAGE | CYANAMIDE...

8. Oncoprotein SET dynamically regulates cellular stress response through nucleocytoplasmic transport in breast cancer NSTL国家科技图书文献中心

Zhao, Guomeng | Zhang, Hongying ... - 《Cell Biology and Toxicology》 - 2023,39(4) - 1795～1814 - 共20页

摘要：SET beta is the predominant isoform of | oncoprotein SE translocation (SET) in various breast cancer | cell lines. Interactome-transcriptome analysis has | shown that SET beta is intimately associated with | cellular stress response. Among various exogenous stimuli

关键词： SET | Formaldehyde | HER2 | p38 alpha | Stress granule | SET/TAF-I-BETA | PROTEIN SET | KINASE | FORMALDEHYDE | INHIBITION...

9. Direct transcriptomic comparison of xenobiotic metabolism and toxicity pathway induction of airway epithelium models at an air-liquid interface generated from induced pluripotent stem cells and primary bronchial epithelial cells NSTL国家科技图书文献中心

Djidrovski, Ivo | Georgiou, Maria ... - 《Cell Biology and Toxicology》 - 2023,39(1) - 31～31 - 共1页 - 被引量：2

摘要：The airway epithelium represents the main | barrier between inhaled air and the tissues of the | respiratory tract and is therefore an important point of | contact with xenobiotic substances into the human body | . Several studies have recently shown that in vitro models

关键词： Induced pluripotent stem cells | Airway epithelium | Air-liquid interface | Toxicity assessment | Transcriptomics | CYTOCHROMES P450 1A1 | HUMAN LUNG | EXPRESSION | ENZYMES | GENE...

10. METTL14 promotes doxorubicin-induced cardiomyocyte ferroptosis by regulating the KCNQ1OT1-miR-7-5p-TFRC axis NSTL国家科技图书文献中心

Zhuang, Shaowei | Ma, Yan ... - 《Cell Biology and Toxicology》 - 2023,39(3) - 1015～1035 - 共21页 - 被引量：44

摘要：Doxorubicin (DOX) has toxic effects on the | heart, causing cardiomyopathy and heart injury, but | the underlying mechanisms of these effects require | further investigation. This study investigated the role | of DOX in promoting ferroptosis to induce