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1. Attrition and discontinuation in amyotrophic lateral sclerosis clinical trials: a meta-analysis NSTL国家科技图书文献中心

van Eijk, Ruben P. A... |  van Loon, Floris T.... -  《Journal of neurology》 - 2025,272(1) - Article: 40~Article: 40 - 共8页

摘要:Objectives Attrition due to adverse events and disease progression impacts the integrity and generalizability of clinical trials. The aim of this study is to provide evidence-based estimates of attrit...
关键词: Treatment discontinuation |  Attrition |  Clinical trials |  Meta-analysis |  ALS

2. Cognitive impairment within and beyond the FTD spectrum in ALS: development of a complementary cognitive screen NSTL国家科技图书文献中心

Michielsen, Annebell... |  van Veenhuijzen, Kev...... -  《Journal of neurology》 - 2025,272(4) - Article 268~Article 268 - 共12页

摘要:ObjectiveTo investigate cognitive impairments in amyotrophic lateral sclerosis (ALS), extending both within and beyond the established frontotemporal dementia (FTD) spectrum, using the Complementary C...
关键词: Amyotrophic lateral sclerosis |  Motor neuron disease |  Cognition |  Frontotemporal dementia |  Cognitive screening instrument |  Social cognition

3. Diagnosing primary lateral sclerosis: a clinico-pathological study NSTL国家科技图书文献中心

de Boer, Eva M. J. |  de Vries, Balint S.... -  《Journal of neurology》 - 2025,272(1) - Article: 46~Article: 46 - 共12页

摘要:Background Primary lateral sclerosis (PLS) is a rare motor neuron disease characterized by upper motor neuron degeneration, diagnosed clinically due to the absence of a (neuropathological) gold standa...
关键词: Primary lateral sclerosis |  Amyotrophic lateral sclerosis |  TDP-43 |  Tau |  Neuropathology

4. Cultivating Patient Preferences in ALS Clinical Trials Reliability and Prognostic Value of the Patient-Ranked Order of Function NSTL国家科技图书文献中心

van Eijk, Ruben P. A... |  van den Berg, Leonar...... -  《Neurology.》 - 2024,103(2) - e209502~e209502 - 共6页

摘要:Background and Objectives The Patient-Ranked Order of Function (PROOF) is a novel approach to account for patient-reported preferences in the evaluation of treatments of amyotrophic lateral sclerosis ...
关键词: END-POINT

5. Harmonized standard operating procedures for administering the ALS functional rating scale-revised NSTL国家科技图书文献中心

Shefner, Jeremy M. |  Bunte, Tommy... -  《Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration》 - 2024,25(1/2) - 26~33 - 共8页 - 被引量:1

摘要:The ALS Functional Rating Scale-Revised is the most commonly used primary outcome measure in current ALS clinical trials. While rigorous training and certification is generally recognized as critical ...
关键词: Clinical trial |  ALSFRS-R |  training |  AMYOTROPHIC-LATERAL-SCLEROSIS |  ANTISENSE OLIGONUCLEOTIDE TOFERSEN |  DOUBLE-BLIND |  CLINICAL-TRIAL |  PLACEBO |  DEXPRAMIPEXOLE |  EFFICACY...

7. Familial motor neuron disease: co-occurrence of PLS and ALS (-FTD) NSTL国家科技图书文献中心

De Boer, Eva M. J. |  Demaegd, Koen C.... -  《Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration》 - 2024,25(1/2) - 53~60 - 共8页

摘要:ObjectiveTo report the frequency and characteristics of patients diagnosed with primary lateral sclerosis (PLS) with a positive family history for motor neuron diseases (MND) in the Netherlands and to...
关键词: primary lateral sclerosis |  motor neuron disease |  familial |  PRIMARY LATERAL SCLEROSIS |  FRONTOTEMPORAL DEMENTIA |  NEUROPATHOLOGY |  MUTATION

8. Assessment of risk of ALS conferred by the GGGGCC hexanucleotide repeat expansion in C9orf72 among first-degree relatives of patients with ALS carrying the repeat expansion NSTL国家科技图书文献中心

Van Wijk, Iris F. |  Van Eijk, Ruben P. A...... -  《Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration》 - 2024,25(1/2) - 188~196 - 共9页 - 被引量:5

摘要:Objectives We aimed to estimate the age-related risk of ALS in first-degree relatives of patients with ALS carrying the C9orf72 repeat expansion.Methods We included all patients with ALS carrying a C9...
关键词: penetrance |  c9orf72 |  ASSOCIATION ANALYSES |  PRESYMPTOMATIC ALS |  FAMILY-SIZE |  PENETRANCE |  IDENTIFY |  SPECTRUM

9. International network for ALS research and care (INARC) NSTL国家科技图书文献中心

Foucher, Juliette |  Bunte, Tommy M.... -  《Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration》 - 2024,25(7/8) - 795~796 - 共2页

摘要:The International Network for Amyotrophic Lateral Sclerosis (ALS) Research and Care (INARC) was founded in 2022. INARC's main goals are to offer a platform dedicated to staff members for ALS clinics a...
关键词: Amyotrophic lateral sclerosis |  network |  cooperation |  international |  report

10. Association Between Hypothalamic Volume and Metabolism, Cognition, and Behavior in Patients With Amyotrophic Lateral Sclerosis NSTL国家科技图书文献中心

Michielsen, Annebell... |  van Veenhuijzen, Kev...... -  《Neurology.》 - 2024,103(2) - e209603~e209603 - 共6页 - 被引量:1

摘要:Background and ObjectivesDysfunction of energy metabolism, cognition, and behavior are important nonmotor symptoms of amyotrophic lateral sclerosis (ALS), negatively affecting survival and quality of ...
关键词: ALS |  SPECTRUM |  ONSET
检索条件作者:van den Berg, Leonard H.

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