Schnegg-Kaufmann, An... |  Thoms, Julie A. I.... -  《Blood: The Journal of the American Society of Hematology》 - 2023,141(11) - 1316～1321 - 共6页

摘要：Myelodysplastic neoplasms (MDSs) and chronic myelomonocytic leukemia (CMML) are clonal disorders driven by progressively acquired somatic mutations in hematopoietic stem cells (HSCs). Hypomethylating ...

关键词： MYELODYSPLASTIC SYNDROMES |  AZACITIDINE |  MUTATIONS |  CANCER

Zandavi, Seid Miad |  Koch, Forrest C.... -  《Nucleic Acids Research》 - 2022,50(10) - 5482～5492 - 共11页

摘要：Emerging single-cell technologies provide high-resolution measurements of distinct cellular modalities opening new avenues for generating detailed cellular atlases of many and diverse tissues. The hig...

关键词： GENE-EXPRESSION

Chandrakanthan, Vash... |  Rorimpandey, Prunell...... -  《Nature cell biology》 - 2022,24(8) - 1211～1225 - 共15页

摘要：Chandrakanthan et al. identify Mesp1-derived PDGFRA(+) stromal cells as aortic endothelial precursors that regulate long-term haematopoietic-stem-cell generation during development, thus providing a n...

关键词： DIFFERENTIAL EXPRESSION ANALYSIS |  SMOOTH-MUSCLE-CELLS |  PDGF RECEPTOR-ALPHA |  PROGENITOR CELLS |  BONE-MARROW |  DEFINITIVE HEMATOPOIESIS |  MYELOID PROGENITORS |  ENDOTHELIAL-CELLS |  AGM REGION |  YOLK-SAC

Thoms, Julie A. I. |  Truong, Peter... -  《Blood: The Journal of the American Society of Hematology》 - 2021,138(16) - 1441～1455 - 共15页

摘要：Changes in gene regulation and expression govern orderly transitions from hematopoietic stem cells to terminally differentiated blood cell types. These transitions are disrupted during leukemic transf...

关键词： ACUTE MYELOID-LEUKEMIA |  ACUTE LYMPHOBLASTIC-LEUKEMIA |  TRANSCRIPTION FACTOR ERG |  GENOME-WIDE ANALYSIS |  ETS-RELATED GENE |  HEMATOPOIETIC REGULATORS |  EXPRESSION LEVELS |  ANALYSIS REVEALS |  GATA2 |  OVEREXPRESSION

Pu, Szu-Yuan |  Xiao, Fei... -  《Antiviral Research》 - 2018,155 - 67～75 - 共9页

摘要：There is an urgent need for strategies to combat dengue virus (DENV) infection; a major global threat. We reported that the cellular kinases AAK1 and GAK regulate intracellular trafficking of multiple...

关键词： Dengue virus |  Antivirals |  Kinase inhibitors |  Drug repurposing |  Virus-host interactions

Zanini, Fabio |  Robinson, Makeda L.... -  《Proceedings of the National Academy of Sciences of the United States of America.》 - 2018,115(52) - E12363～E12369 - 共7页

摘要：Dengue virus (DENV) infection can result in severe complications. However, the understanding of the molecular correlates of severity is limited, partly due to difficulties in defining the peripheral b...

关键词： dengue |  single cell |  transcriptomics |  biomarkers |  virus-host interactions

Schiroli, Consuelo |  Carugati, Manuela... -  《Infection》 - 2015,43(6) - 647～653 - 共7页

摘要：Recurrence of tuberculosis (TB) can be the consequence of relapse or exogenous reinfection. The study aimed to assess the factors associated with exogenous TB reinfection.

关键词： Tuberculosis |  Exogenous reinfection |  Relapse |  Fingerprinting

Hartmann, Marcus D. |  Boichenko, Iuliia... -  《Journal of Structural Biology》 - 2014,188(3) - 225～232 - 共8页

摘要：Thalidomide and its derivatives lenalidomide and pomalidomide are important anticancer agents but can cause severe birth defects via an interaction with the protein cereblon. The ligand-binding domain...

关键词： Immunomodulatory drug |  IMiD |  Revlimid |  Pomalyst

Zanini, Fabio |  Carugati, Manuela... -  《Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases》 - 2014,25 - 14～19 - 共6页

摘要：The Mycobacterium tuberculosis Beijing genotype raises major concern because of global spreading, hypervirulence and association with multi-drug resistance (MDR). The aims of the study were to evaluat...

关键词： Mycobacterium tuberculosis |  Beijing family |  Tuberculosis |  Molecular typing |  Multi-drug resistance

Putri, Givanna H. |  Anders, Simon... -  《Bioinformatics》 - 2022,38(10) - 2943～2945 - 共3页

摘要：A Summary: HTSeq 2.0 provides a more extensive application programming interface including a new representation for sparse genomic data, enhancements for htseq-count to suit single-cell omics, a new s...