Shemesh, Colby S. |  Chan, Phyllis... -  《Clinical Pharmacology and Therapeutics》 - 2023,114(3) - 644～651 - 共8页

摘要：We assess the longitudinal tumor growth inhibition (TGI) metrics and overall survival (OS) predictions applied to patients with advanced biliary tract cancer (BTC) enrolled in IMbrave151 a multicenter...

关键词： SIZE RESPONSE METRICS |  PREDICT SURVIVAL |  SIMULATIONS |  BEVACIZUMAB |  ONCOLOGY

Samineni, Divya |  Gibiansky, Leonid... -  《Advances in therapy.》 - 2022,39(8) - 3635～3653 - 共19页

摘要：Introduction This study aims to investigate pharmacokinetics (PK) and exposure-response parameters of the 400 mg once-daily venetoclax dose regimen in combination with obinutuzumab, which was approved...

关键词： Drug safety |  Effectiveness |  Cancer |  Pharmacokinetics |  BCL-2 INHIBITOR |  17P DELETION |  OPEN-LABEL |  CHLORAMBUCIL |  MULTICENTER |  RITUXIMAB...

Lu, Dan |  Li, Chunze... -  《Cancer chemotherapy and pharmacology.》 - 2019,84(1) - 175～185 - 共11页

摘要：PurposeThe phase III MARIANNE study investigated single-agent trastuzumab emtansine (T-DM1) and combination T-DM1 plus pertuzumab as the first-line treatment for human epidermal growth factor receptor...

关键词： Trastuzumab emtansine (T-DM1) |  HER2 |  Pharmacokinetics |  Previously untreated metastatic breast cancer |  MARIANNE

Zhu, Rui |  Zheng, Yanan... -  《Pulmonary pharmacology & therapeutics》 - 2017,46 - 88～98 - 共11页

摘要：Lebrikizumab is a humanized monoclonal antibody that binds to interleukin-13 and has been evaluated as a treatment for moderate-to-severe asthma. Objectives of this work were to characterize lebrikizu...

关键词： Asthma |  Anti-IL-13 |  Lebrikizumab |  Population PK |  Exposure-response |  Monoclonal antibody

Wang, Nina X. |  Liu, Qi... -  《Journal of pharmacokinetics and pharmacodynamics》 - 2016,43(Suppl.) - S72～S73 - 共2页

Chan, Phyllis |  Marchand, Mathilde... -  《CPT: Pharmacometrics & Systems Pharmacology》 - 2021,10(10) - 1171～1182 - 共12页

摘要：The objectives of the study were to use tumor size data from 10 phase II/III atezolizumab studies across five solid tumor types to estimate tumor growth inhibition (TGI) metrics and assess the impact ...

关键词： OPEN-LABEL |  CANCER |  MULTICENTER |  ONCOLOGY |  SIZE |  THERAPEUTICS |  ASSOCIATION |  SIMULATION |  DOCETAXEL |  KINETICS

Svensson, Robin J. |  Ribbing, Jakob... -  《CPT: Pharmacometrics & Systems Pharmacology》 - 2021,10(10) - 1221～1235 - 共15页

摘要：Identification of covariates, including biomarkers, spirometry, and diaries/questionnaires, that predict asthma exacerbations would allow better clinical predictions, shorter phase II trials and infor...

关键词： UNCONTROLLED ASTHMA |  END-POINTS |  MODEL |  DISEASE |  TRIALS |  COUNT |  PSN