Thiede, Joshua M. |  Gress, Abigail R.... -  《The Journal of Infectious Diseases》 - 2021,223(8) - 1339～1344 - 共6页 - 被引量：3

摘要：Coronavirus disease 2019 (COVID-19) outcomes are linked to host immune responses and may be affected by antiviral therapy. We investigated antibody and cytokine responses in ACTT-1 study participants ...

关键词： COVID-19 |  remdesivir |  ACTT-1 |  neutralization |  serology |  cytokine |  trajectory

Gniadek, Thomas J. |  Thiede, Joshua M.... -  《Transfusion: The Journal of the American Association of Blood Banks》 - 2021,61(1) - 17～23 - 共7页 - 被引量：10

摘要：Background The transfer of passive immunity with convalescent plasma is a promising strategy for treatment and prevention of COVID-19, but donors with a history of nonsevere disease are serologically ...

Minato, Yusuke |  Thiede, Joshua M.... -  《Antimicrobial agents and chemotherapy.》 - 2015,59(9) - 5097～5106 - 共10页 - 被引量：50

摘要：para-Aminosalicylic acid (PAS) entered clinical use in 1946 as the second exclusive drug for the treatment of tuberculosis (TB). While PAS was initially a first-line TB drug, the introduction of more ...

Gress, Abigail R. |  Ronayne, Christine E...... -  《Nature Communications》 - 2023,14(1) - 共16页

摘要：After Mycobacterium tuberculosis (Mtb) infection, many effector T cells traffic to the lungs, but few become activated. Here we use an antigen receptor reporter mouse (Nur77-GFP) to identify recently ...

关键词： IFN-GAMMA |  INFECTION |  MEMORY |  DIFFERENTIATION |  PROTECTION |  SURVIVAL |  IMMUNITY |  DRIVES |  4-1BB |  MICE

Fiege, Jessica K. |  Thiede, Joshua M.... -  《plos pathogens》 - 2021,17(1) - 共15页 - 被引量：42

摘要：The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how the heterogeneity of this diverse cell population contr...

关键词： DYNAMICS

Ubah, Obinna C. |  Lake, Eric W.... -  《Nature Communications》 - 2021,12(1) - 共12页

摘要：Shark antibodies (Variable New Antigen Receptors, VNARs) are the smallest naturally occurring antibody fragments. Here, the authors screen a VNAR phage display library against the SARS-CoV2 receptor b...

关键词： IMMUNODEFICIENCY-VIRUS TYPE-1 |  BINDING DOMAIN |  ANTIBODIES |  VPR

Minato, Yusuke |  Gohl, Daryl M.... -  《msystems》 - 2019,4(4) - 共13页 - 被引量：41

摘要：A better understanding of essential cellular functions in pathogenic bacteria is important for the development of more effective antimicrobial agents. We performed a comprehensive identification of es...

关键词： comparative genomics |  metabolic modeling |  metabolism |  Tn-seq |  tuberculosis |  CONSTRAINT-BASED MODELS |  QUANTITATIVE PREDICTION |  CELLULAR-METABOLISM |  ESSENTIAL GENES |  DATABASE...

Thiede, Joshua M. |  Kordus, Shannon L.... -  《scientific reports》 - 2016,6 - 共8页 - 被引量：18

摘要：The ability to revitalize and re-purpose existing drugs offers a powerful approach for novel treatment options against Mycobacterium tuberculosis and other infectious agents. Antifolates are an underu...

关键词： PARA-AMINOSALICYLIC ACID |  MYCOBACTERIUM-TUBERCULOSIS |  FOLATE METABOLISM |  RESISTANCE |  DETERMINANTS |  EXPRESSION |  SYNTHASE