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1. Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Hossain, Jubayer A. |  Latif, Md A.... -  《Neuro-oncology》 - 2019,21(7) - 890～900 - 共11页 - 被引量：16

摘要：Background Suicide gene therapy for malignant gliomas has shown encouraging results in the latest clinical trials. However, prodrug application was most often restricted to short-term treatment (14 da...
关键词： brain tumors |  EGFR |  glioblastoma |  lentiviral vectors |  suicide gene therapy
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2. The angiogenic switch leads to a metabolic shift in human glioblastoma SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Talasila, Krishna M. |  Rosland, Gro V.... -  《Neuro-oncology》 - 2017,19(3) - 383～393 - 共11页 - 被引量：20

摘要：Background. Invasion and angiogenesis are major hallmarks of glioblastoma (GBM) growth. While invasive tumor cells grow adjacent to blood vessels in normal brain tissue, tumor cells within neovascular...
关键词： angiogenesis |  glioblastoma |  glycolysis |  hypoxia |  invasion
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3. EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation NSTL国家科技图书文献中心

Eskilsson, Eskil |  Rosland, Gro V.... -  《Neuro-oncology》 - 2016,18(12) - 1644～1655 - 共12页 - 被引量：60

摘要：Background. Amplification of the epidermal growth factor receptor (EGFR) and its mutant EGFRvIII are among the most common genetic alterations in glioblastoma (GBM), the most frequent and most aggress...
关键词： angiogenesis |  EGFR |  EGFRvIII |  glioblastoma |  invasion
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4. Cathepsin L silencing enhances arsenic trioxide mediated in vitro cytotoxicity and apoptosis in glioblastoma U87MG spheroids SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Primon, Monika |  Huszthy, Peter C.... -  《Experimental Cell Research》 - 2013,319(17) - 2637～2648 - 共12页 - 被引量：14

摘要：Despite improved treatment options, glioblastoma multiforme (GBM) remains the most aggressive brain tumour with the shortest post-diagnostic survival. Arsenite (As2O3) is already being used in the tre...
关键词： Apoptosis |  Arsenic trioxide |  Cathepsin L |  Glioblastoma multiforme |  U87MG spheroids |  Multicellular resistance effect
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5. Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts

Leiss, Lina |  Mutlu, Ercan... -  《bmc cancer》 - 2017,17 - 共13页 - 被引量：6

摘要：Background: Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers.Methods: We isolated stromal...
关键词： Glioblastoma |  Tumour-host interplay |  Tumour-associated glial cells |  GFF-NOD/scid mice |  Xenograft tumours |  Gene expression analysis |  Stem cell markers |  POU3F2 |  CENTRAL-NERVOUS-SYSTEM |  MODEL...
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6. Expansive growth of two glioblastoma stem-like cell lines is mediated by bFGF and not by EGF

Podergajs, Neza |  Brekka, Narve... -  《radiology and oncology》 - 2013,47(4) - 330～337 - 共8页 - 被引量：15

摘要：

Background. Patient-derived glioblastoma (GBM) stem-like cells (GSCs) represent a valuable model for basic and therapeutic research. GSCs are usually propagated in serum-...

关键词： glioblastoma |  bFGF |  EGF |  EGFR |  stem cell cultures |  FACTOR RECEPTOR |  EXPRESSION |  CANCER |  TUMOR |  GLIOMA...
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7. Tumor versus Stromal Cells in Culture-Survival of the Fittest?

Talasila, Krishna M. |  Brekka, Narve... -  《plos one》 - 2013,8(12) - 共12页 - 被引量：5

摘要：Two of the signature genetic events that occur in human gliomas, EGFR amplification and IDH mutation, are poorly represented in experimental models in vitro. EGFR amplification, for example, occurs in...
关键词： MESENCHYMAL STEM-CELLS |  GROWTH-FACTOR RECEPTORS |  HUMAN GLIOBLASTOMA |  GLIOMA-CELLS |  FATE CHOICE |  IN-VIVO |  LINES |  EXPRESSION |  TUMORIGENICITY |  XENOGRAFTS
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