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2. An LC-MS/MS method for bioanalysis of a molecular glue, pomalidomide, at sub-ng/mL levels in human plasma NSTL国家科技图书文献中心

Eshani Galermo |  Ebru Selen... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.2》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 494825~494825 - 共1页

摘要:1. Immunomodulatory drugs (IMiD), such as pomalidomide (Figure 1), are a novel group of orally available chemotherapy agents. Pomalidomide behaves as a molecular glue which is commonly administered as...

3. Quantitation of a glucagon-like peptide-1 (GLP-1) analog in rat plasma using an LC-MS/MS workflow NSTL国家科技图书文献中心

Amy Knight |  Ebru Selen... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.3》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 495999~495999 - 共1页

摘要:1. There has been an increased attention towards GLP-1 analogs as they aid in the regulation of systemic homeostasis. GLP-1 analogs, such as orally available semglutide, is clinically approved and use...

4. Electron Activated Dissociation (EAD) for elucidating the structures of synthetic small molecules MP099 NSTL国家科技图书文献中心

Shuai Wu |  Rahul Baghla... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.1》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 492999~492999 - 共1页

摘要:Sotorasib is an inhibitor of the RAS GTPase family that is used to treat KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer. Imidazolones were found to serve as amide bioisost...

5. Sensitive quantitation of glucagon-like peptide-1 (GLP-1) analog in rat plasma NSTL国家科技图书文献中心

Tanya Gamble |  Ebru Selen... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.3》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 496000~496000 - 共1页

摘要:1. GLP-1 analogs, including liraglutide, are clinically approved to improve glycemic control in patients with type 2 diabetes mellitus, with additional benefits on weight reduction and cardiovascular ...

6. Low-pg/mL quantitation of leucine-rich repeat kinase 2 (LRRK2) using LC-MS/MS in human cerebrospinal fluid (CSF) NSTL国家科技图书文献中心

Dylan Bennett |  Arash Rassoulpour... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.3》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 495039~495039 - 共1页

摘要:Mutations in the gene encoding for leucine-rich repeat kinase 2 (LRRK2) are among the most common causes of familial and sporadic cases of Parkinson's disease (PD). LRRK2 is therefore a promising targ...

7. Redefining bioanalysis: assessment of a mass spectrometer robustness versus complex matrix NSTL国家科技图书文献中心

Elliott Jones |  Rahul Baghla... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.3》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 495829~495829 - 共1页

摘要:1. To ensure accurate and precise results, analytical labs need reliable and robust instruments and methods. Bioanalytical methods that can handle the inherent variability of analyzing diverse samples...

8. Sensitive and selective quantitation of bimatoprost in human plasma using accurate mass spectrometry NSTL国家科技图书文献中心

Sujata Rajan |  Sashank Pillai... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.3》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 495828~495828 - 共1页

摘要:1. Bimatoprost is a widely used medication for treating glaucoma by reducing intraocular pressure. When one drop of 0.03% bimatoprost was administered to both eyes daily for 2 weeks, blood concentrati...

9. Enhancing BBB Integrity Biomarker Quantitation in Neurovascular Disorder Research through Microflow Solutions NSTL国家科技图书文献中心

Dhavalkumar Patel |  Ehsan Nozohouri... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.2》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 494406~494406 - 共1页

摘要:This study aims to develop a highly sensitive method for quantifying the integrity of the blood-brain barrier (BBB) using stable isotope-labeled sucrose, [13C12]Sucrose, as the biomarker in the Laser-...

10. Confident characterization and identification of glucuronide metabolites using diagnostic fragments from orthogonal MS/MS data NSTL国家科技图书文献中心

Rahul Baghla -  《71st ASMS Conference on Mass Spectrometry and Allied Topics, Vol.1: Houston, TX, USA.June 4-8 2023》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2023, - 474172.1-474172.1~ - 共1页

摘要:1.Electron activated dissociation combined with the Zeno trap shows great promise as a new fragmentation technique for delivering information that is complementary to CID. 2.Using examples such as dar...
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