全部 |
  • 全部
  • 题名
  • 关键词
  • NSTL主题词
  • 摘要
  • 论文-出处
  • 论文-作者
  • 论文-机构
  • 论文-DOI
  • 期刊-出版者
  • 期刊-出版地
  • 期刊-主编
  • ISSN
  • EISSN
  • ISBN
  • EISBN
检索 搜索期刊 二次检索 AI检索
外文文献 中文文献
筛选条件:

1. Contemporary Approach to the Diagnosis and Classification of Myelodysplastic Neoplasms/Syndromes-Recommendations From the International Consortium for Myelodysplastic Neoplasms/Syndromes (MDS [icMDS]) NSTL国家科技图书文献中心

Fnu Aakash |  Savanah D Gisriel... -  《Modern pathology》 - 2024,37(12) - 100615~100615 - 共6页

摘要:Myelodysplastic neoplasms/syndromes (MDS) are a heterogeneous group of biologically distinct entities characterized by variable degrees of ineffective hematopoiesis. Recently, 2 classification systems...
关键词: MDS; classification; diagnosis; icMDS; myelodysplastic neoplasms; myelodysplastic syndromes

2. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission NSTL国家科技图书文献中心

M. Ryan Corces-Zimme... |  Wan-Jen Hong... -  《Proceedings of the National Academy of Sciences of the United States of America》 - 2014,111(7) - 2548~2553 - 共6页 - 被引量:414

摘要:Cancer is widely characterized by the sequential acquisition of genetic lesions in a single lineage of cells. Our previous studies have shown that, in acute myeloid leukemia (AML), mutation acquisitio...
关键词: preleukemia |  clonal evolution

3. Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia NSTL国家科技图书文献中心

Haijiao Zhang |  Yusuke Nakauchi... -  《Nature cancer.》 - 2020,1(8) - 826~839 - 共14页

摘要:Deregulation of the BCL2 gene family plays an important role in the pathogenesis of acute myeloid leukemia (AML). A BCL2 inhibitor, venetoclax, has received approval from the US Food and Drug Administ...

5. Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist NSTL国家科技图书文献中心

Michael R. McKeown |  M. Ryan Corces... -  《Cancer discovery.》 - 2017,7(10) - 1136~1153 - 共18页 - 被引量:76

摘要:We characterized the enhancer landscape of 66 patients with acute myeloid leukemia (AML), identifying 6 novel subgroups and their associated regulatory loci. These subgroups are defined by their super...

8. Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Steven M Chan |  Daniel Thomas... -  《Nature medicine》 - 2015,21(2) - 178~184 - 共7页 - 被引量:312

摘要:Mutant isocitrate dehydrogenase (IDH) 1 and 2 proteins alter the epigenetic landscape in acute myeloid leukemia (AML) cells through production of the oncometabolite (R)-2-hydroxyglutarate (2-HG). Here...

9. Programmed cell removal: a new obstacle in the road to developing cancer NSTL国家科技图书文献中心

Mark P. Chao |  Ravindra Majeti... -  《Nature reviews Cancer》 - 2012,12(1) - 58~67 - 共10页

摘要:The development of cancer involves mechanisms by which aberrant cells overcome normal regulatory pathways that limit their numbers and their migration. The evasion of programmed cell death is one of s...

10. Leukemic Stem Cell Gene Expression Signature and Clinical Outcomes in Acute Myeloid Leukemia—Reply SCIE Web of Science核心 NSTL国家科技图书文献中心

Andrew J. Gentles |  Ravindra Majeti... -  《JAMA: the Journal of the American Medical Association》 - 2011,305(11) - 1094~1094 - 共1页

摘要:In Reply: The important recent characterization of mutations in the DNA methyltransferase gene DNMT3A and association with adverse patient outcomes1 was performed on 1 of the patient cohorts included ...
检索条件作者:Ravindra Majeti

NSTL主题词

  • NSTL学科导航