Kyle, Ryan L. |  Prout, Melanie... -  《Immunology and cell biology.》 - 2024,102(3) - 194～211 - 共18页

摘要：T helper 2 (Th2) cells stochastically express from the Il4 locus but it has not been determined whether allelic expression is linked or independent. Here, we provide evidence that alleles are independ...

关键词： allelic biasing |  gene regulation |  IL-4 |  Th2 cells |  transcription |  IN-VIVO |  TH2 CELLS |  PROBABILISTIC REGULATION |  MONOALLELIC EXPRESSION |  GENE-EXPRESSION...

Torres, Santiago Val... |  Man, Kevin... -  《Nature immunology》 - 2024,25(3) - 共39页 - 被引量：16

摘要：Visceral adipose tissue (VAT) is an energy store and endocrine organ critical for metabolic homeostasis. Regulatory T (Treg) cells restrain inflammation to preserve VAT homeostasis and glucose toleran...

关键词： PPAR-GAMMA |  REG CELLS |  INFLAMMATION |  IL-33 |  GENE |  BET |  EXPRESSION |  RECEPTOR |  FAT |  ACCUMULATION

Ochiai, Sotaro |  Jagot, Ferdinand... -  《Proceedings of the National Academy of Sciences of the United States of America.》 - 2018,115(5) - 1033～1038 - 共6页 - 被引量：41

摘要：T helper 2 (Th2) cells are pivotal in the development of allergy. Allergen exposure primes IL-4(+) Th2 cells in lymph node, but production of effector cytokines including IL-5 and IL-13 is thought to ...

关键词： TSLP |  Th2 cells |  effector T cells |  IL-13 |  IL-4

Robinson, Marcus J. |  Prout, Melanie... -  《The Journal of Immunology: Official Journal of the American Association of Immunologists》 - 2017,198(5) - 1815～1822 - 共8页 - 被引量：13

摘要：Polymorphisms in genes involved in IL-4 responses segregate with allergic disease risk and correlate with IgE levels in humans, and IL-4 promotes IgE and IgG1 Ab production against allergens in mice. ...

Pellefigues, Christo... |  Mehta, Palak... -  《frontiers in immunology》 - 2019,10 - 共13页 - 被引量：16

摘要：

Basophils are granulocytes involved in parasite immunity and allergic diseases, known for their potent secretion of type 2 cytokines. Identifying their functions has prov...

关键词： basophil |  Basoph8 |  depletion |  flow cytometry |  phenotype |  MAST-CELLS |  DENDRITIC CELLS |  HELPER-CELLS |  SKIN |  IL-4...

Prout, Melanie Sarah |  Kyle, Ryan L.... -  《frontiers in immunology》 - 2018,9 - 共11页 - 被引量：14

摘要：

Although IL-4 is long associated with CD4 Th2 immune responses, its role in Th2 subset development in non-lymphoid tissues is less clear. We sought to better define IL-4'...

关键词： Th2 |  IL-4 |  IL-13 |  skin |  lymph node |  lung |  non-lymphoid tissues |  FOLLICULAR-HELPER-CELLS |  INTESTINAL HELMINTH INFECTION |  IN-VIVO...