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1. Circulating insulin-like growth factor-1 and the risk of multiple sclerosis: a prospective cohort study NSTL国家科技图书文献中心

Pang, Xiao-Wei |  Yang, Sheng... -  《Multiple Sclerosis and Related Disorders》 - 2025,94 - 106281~106281 - 共6页

摘要:Background: Circulating insulin-like growth factor 1 (IGF-1) is positively associated with the risks of certain neurological disorders, including stroke, Alzheimer's disease, and Parkinson's disease. ...
关键词: Insulin-like growth factor-1 (IGF-1) |  Multiple sclerosis |  Biomarkers |  UK biobank

2. Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders NSTL国家科技图书文献中心

Qin, Chuan |  Chen, Man... -  《Brain: A journal of neurology》 - 2024,147(1) - 163~176 - 共14页

摘要:Microglia-mediated neuroinflammation contributes to acute demyelination in neuromyelitis optica spectrum disorders (NMOSD). Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in the CSF...
关键词: neuromyelitis optica spectrum disorders |  soluble TREM2 |  microglia |  CEREBROSPINAL-FLUID |  MULTIPLE-SCLEROSIS |  ALZHEIMERS-DISEASE |  CLEAVAGE |  INJURY |  STREM2

3. Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia

Zhang, Hang |  Yang, Sheng... -  《redox biology》 - 2025,79 - 共14页

摘要:Background: Oxidative stress and microglial activation are critical pathomechanisms in ischemic white matter injury. Microglia, as resident immune cells in the brain, are the main cells undergoing oxi...
关键词: Chronic cerebral hypoperfusion |  Oxidative stress |  Microglia |  Nrf2 |  Lipid metabolism |  Ferroptosis |  OXIDATIVE STRESS |  MITOCHONDRIAL DYSFUNCTION |  DAMAGE |  BRAIN...

4. Causal association between the peripheral immunity and the risk and disease severity of multiple sclerosis

Chen, Lian |  Zhu, Li-Fang... -  《frontiers in immunology》 - 2024,15 - 共9页

摘要:Background Growing evidence links immunological responses to Multiple sclerosis (MS), but specific immune factors are still unclear.Methods Mendelian randomization (MR) was performed to investigate th...
关键词: multiple sclerosis |  Mendelian randomization (MR) |  genome wide association study (GWAS) |  peripheral immune cells |  cytokines |  REGULATORY T-CELLS |  B-CELLS |  METAANALYSIS

5. The foam cell-derived exosomal miRNA Novel-3 drives neuroinflammation and ferroptosis during ischemic stroke

Qin, Chuan |  Dong, Ming-Hao... -  《Nature Aging》 - 2024,4(12) - 1845~+ - 共30页

摘要:Large artery atherosclerosis (LAA) is a prevalent cause of acute ischemic stroke (AIS). Understanding the mechanisms linking atherosclerosis to stroke is essential for developing appropriate intervent...
关键词: STRIATIN

6. Systematic Druggable Genome-Wide Mendelian Randomization Identifies Therapeutic Targets for Functional Outcome After Ischemic Stroke

Zhang, Lu-Yang |  Chu, Yun-Hui... -  《Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease》 - 2024,13(16) - 共13页

摘要:Background: Stroke is a leading cause of death worldwide, with a lack of effective treatments for improving the prognosis. The aim of the present study was to identify novel therapeutic targets for fu...
关键词: drug target |  functional outcome |  genetics |  Mendelian randomization |  stroke |  RECEPTOR-BINDING PROTEIN-1 |  BLOOD-BRAIN-BARRIER |  INSTRUMENTS |  INFERENCE |  SEX

7. TREM2-IGF1 Mediated Glucometabolic Enhancement Underlies Microglial Neuroprotective Properties During Ischemic Stroke

Yang, Sheng |  Qin, Chuan... -  《advanced science》 - 2024,11(10) - 共15页

摘要:Microglia, the major resident immune cells in the central nervous system, serve as the frontline soldiers against cerebral ischemic injuries, possibly along with metabolic alterations. However, signal...
关键词: ischemic stroke |  microglia |  oxidative phosphorylation |  Trem2-Igf1 signaling pathway |  MYELOID CELLS |  CREATINE |  CYCLOCREATINE |  INSULIN |  DRIVES |  DAMAGE

8. Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder

Chen, Man |  Chu, Yun-Hui... -  《neuroscience bulletin》 - 2024,40(8) - 1104~1114 - 共11页

摘要:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS) accompanied by blood-brain barrier (BBB) disruption. Dysfunction ...
关键词: Neuromyelitis optica spectrum disorder |  Low-density lipoprotein |  Microglia |  CHOLESTEROL |  RECEPTOR

9. TREM2 deficiency inhibits microglial activation and aggravates demyelinating injury in neuromyelitis optica spectrum disorder

You, Yun-Fan |  Chen, Man... -  《Journal of neuroinflammation》 - 2023,20(1) - 共14页

摘要:Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disorder of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are activated and play a pivo...
关键词: TREM2 |  Microglia |  Neuromyelitis optica spectrum disorder |  Demyelination |  DEBRIS CLEARANCE |  NERVOUS-TISSUE |  LIPIDS |  MYELIN

10. Microglial autophagy in cerebrovascular diseases

Chen, Man |  Zhang, Hang... -  《frontiers in aging neuroscience》 - 2022,14 - 共14页

摘要:Microglia are considered core regulators for monitoring homeostasis in the brain and primary responders to central nervous system (CNS) injuries. Autophagy affects the innate immune functions of micro...
关键词: microglia |  autophagy |  cerebrovascular diseases |  inflammation |  metabolism |  FOCAL CEREBRAL-ISCHEMIA |  MULTIVESICULAR BODIES |  BIOLOGICAL FUNCTIONS |  INFLAMMATORY INJURY |  OXIDATIVE STRESS...
检索条件作者:Pang, Xiao-Wei

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