NSTL国家科技图书文献中心

1. Circulating insulin-like growth factor-1 and the risk of multiple sclerosis: a prospective cohort study NSTL国家科技图书文献中心

Pang, Xiao-Wei | Yang, Sheng ... - 《Multiple Sclerosis and Related Disorders》 - 2025,94 - 106281～106281 - 共6页

摘要：Background: Circulating insulin-like growth factor 1 (IGF-1) is positively associated with the risks of certain neurological disorders, including stroke, Alzheimer's disease, and Parkinson's disease. ...

关键词： Insulin-like growth factor-1 (IGF-1) | Multiple sclerosis | Biomarkers | UK biobank

2. Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders NSTL国家科技图书文献中心

Qin, Chuan | Chen, Man ... - 《Brain: A journal of neurology》 - 2024,147(1) - 163～176 - 共14页 - 被引量：8

摘要：Microglia-mediated neuroinflammation contributes to acute demyelination in neuromyelitis optica spectrum disorders (NMOSD). Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in the CSF...

关键词： neuromyelitis optica spectrum disorders | soluble TREM2 | microglia | CEREBROSPINAL-FLUID | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | CLEAVAGE | INJURY | STREM2

3. Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia

Zhang, Hang | Yang, Sheng ... - 《redox biology》 - 2025,79 - 共14页

摘要：Background: Oxidative stress and microglial activation are critical pathomechanisms in ischemic white matter injury. Microglia, as resident immune cells in the brain, are the main cells undergoing oxi...

关键词： Chronic cerebral hypoperfusion | Oxidative stress | Microglia | Nrf2 | Lipid metabolism | Ferroptosis | OXIDATIVE STRESS | MITOCHONDRIAL DYSFUNCTION | DAMAGE | BRAIN...

4. Causal association between the peripheral immunity and the risk and disease severity of multiple sclerosis

Chen, Lian | Zhu, Li-Fang ... - 《frontiers in immunology》 - 2024,15 - 共9页

摘要：Background Growing evidence links immunological responses to Multiple sclerosis (MS), but specific immune factors are still unclear.Methods Mendelian randomization (MR) was performed to investigate th...

关键词： multiple sclerosis | Mendelian randomization (MR) | genome wide association study (GWAS) | peripheral immune cells | cytokines | REGULATORY T-CELLS | B-CELLS | METAANALYSIS

5. TREM2-IGF1 Mediated Glucometabolic Enhancement Underlies Microglial Neuroprotective Properties During Ischemic Stroke

Yang, Sheng | Qin, Chuan ... - 《advanced science》 - 2024,11(10) - 共15页

摘要：Microglia, the major resident immune cells in the central nervous system, serve as the frontline soldiers against cerebral ischemic injuries, possibly along with metabolic alterations. However, signal...

关键词： ischemic stroke | microglia | oxidative phosphorylation | Trem2-Igf1 signaling pathway | MYELOID CELLS | CREATINE | CYCLOCREATINE | INSULIN | DRIVES | DAMAGE

6. The foam cell-derived exosomal miRNA Novel-3 drives neuroinflammation and ferroptosis during ischemic stroke

Qin, Chuan | Dong, Ming-Hao ... - 《Nature Aging》 - 2024,4(12) - 1845～+ - 共30页

摘要：Large artery atherosclerosis (LAA) is a prevalent cause of acute ischemic stroke (AIS). Understanding the mechanisms linking atherosclerosis to stroke is essential for developing appropriate intervent...

关键词： STRIATIN

7. Systematic Druggable Genome-Wide Mendelian Randomization Identifies Therapeutic Targets for Functional Outcome After Ischemic Stroke

Zhang, Lu-Yang | Chu, Yun-Hui ... - 《Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease》 - 2024,13(16) - 共13页

摘要：Background: Stroke is a leading cause of death worldwide, with a lack of effective treatments for improving the prognosis. The aim of the present study was to identify novel therapeutic targets for fu...

关键词： drug target | functional outcome | genetics | Mendelian randomization | stroke | RECEPTOR-BINDING PROTEIN-1 | BLOOD-BRAIN-BARRIER | INSTRUMENTS | INFERENCE | SEX

8. Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder

Chen, Man | Chu, Yun-Hui ... - 《neuroscience bulletin》 - 2024,40(8) - 1104～1114 - 共11页

摘要：Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS) accompanied by blood-brain barrier (BBB) disruption. Dysfunction ...

关键词： Neuromyelitis optica spectrum disorder | Low-density lipoprotein | Microglia | CHOLESTEROL | RECEPTOR

9. TREM2 deficiency inhibits microglial activation and aggravates demyelinating injury in neuromyelitis optica spectrum disorder

You, Yun-Fan | Chen, Man ... - 《Journal of neuroinflammation》 - 2023,20(1) - 共14页 - 被引量：6

摘要：Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disorder of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are activated and play a pivo...

关键词： TREM2 | Microglia | Neuromyelitis optica spectrum disorder | Demyelination | DEBRIS CLEARANCE | NERVOUS-TISSUE | LIPIDS | MYELIN

10. Microglial autophagy in cerebrovascular diseases

Chen, Man | Zhang, Hang ... - 《frontiers in aging neuroscience》 - 2022,14 - 共14页

摘要：Microglia are considered core regulators for monitoring homeostasis in the brain and primary responders to central nervous system (CNS) injuries. Autophagy affects the innate immune functions of micro...

关键词： microglia | autophagy | cerebrovascular diseases | inflammation | metabolism | FOCAL CEREBRAL-ISCHEMIA | MULTIVESICULAR BODIES | BIOLOGICAL FUNCTIONS | INFLAMMATORY INJURY | OXIDATIVE STRESS...