Stopper, Daniel |  Honin, Irina... -  《ACS medicinal chemistry letters》 - 2025,16(3) - 487～495 - 共9页

摘要：Histone deacetylases (HDACs) are promising targets for epigenetic drug discovery. Additionally, targeted degradation of HDACs has emerged as a novel approach in medicinal chemistry and chemical biolog...

关键词： histone deacetylase (HDAC) |  HDAC degradation |  proteolysis targeting chimeras (PROTACs) |  targeted proteindegradation (TPD) |  zinc-binding group (ZBG)

Stopper, Daniel |  Buntrock, Susanna... -  《European Journal of Medicinal Chemistry》 - 2025,281 - 117045～117045 - 共17页

摘要：In this study, we synthesized and evaluated novel histone deacetylase (HDAC) inhibitors derived from the clinical candidate quisinostat. A library of 16 compounds categorized in three novel chemotypes...

关键词： Histone deacetylase |  HDAC inhibitor |  Malaria |  Cancer |  Multicomponent reaction

Stopper, Daniel |  de Carvalho, Lais Pe...... -  《European Journal of Medicinal Chemistry: Chimie Therapeutique》 - 2024,277 - 116782～116782 - 共6页 - 被引量：1

摘要：Dynamics of epigenetic modifications such as acetylation and deacetylation of histone proteins have been shown to be crucial for the life cycle development and survival of Plasmodium falciparum, the d...

关键词： Histone deacetylase |  HDAC inhibitors |  Malaria |  Peptoid |  Multicomponent reaction |  PLASMODIUM |  DISCOVERY |  ASSAY

Stopper, Daniel |  Schroder-Turk, Gerd ...... -  《Molecular physics》 - 2021,119(15/16) - ARTN e1906968～ - 共10页 - 被引量：3

摘要：Using density functional theory for a simple fluid of hard spheres with a square-well attraction, we study the phase behaviour of the fluid confined in triply periodic porous material, where the pore ...

关键词： Density functional theory |  phase behaviour |  porous material

Stopper, Daniel |  Roth, Roland... -  《Journal of Physics. Condensed Matter》 - 2016,28(45) - 共14页 - 被引量：11

摘要：Within the Asakura-Oosawa model, we study structural relaxation in mixtures of colloids and polymers subject to Brownian motion in the overdamped limit. We obtain the time evolution of the self and di...

关键词： diffusion |  colloids |  classical density functional theory |  colloid polymer mixture |  dynamical density functional theory |  dynamical Monte Carlo simulation

Stopper, Daniel |  Hansen-Goos, Hendrik... -  《The Journal of Chemical Physics》 - 2020,152(11) - 共5页 - 被引量：8

摘要：For a standard model of patchy colloidal fluids with patch number M = 2, where chain formation (polymerization) occurs, we show that Wertheim theory predicts critical behavior at vanishing density and...

Stopper, Daniel |  Hansen-Goos, Hendrik... -  《The Journal of Chemical Physics》 - 2019,151(1) - 共11页 - 被引量：17

摘要：We revisit the competition between attractive and repulsive interparticle forces in simple fluids and how this governs and connects the macroscopic phase behavior and structural properties, as manifes...

Stopper, Daniel |  Thorneywork, Alice L...... -  《The Journal of Chemical Physics》 - 2018,148(10) - 共7页 - 被引量：21

摘要：Using dynamical density functional theory (DDFT), we theoretically study Brownian self-diffusion and structural relaxation of hard disks and compare to experimental results on quasi two-dimensional co...

Stopper, Daniel |  Hirschmann, Frank... -  《The Journal of Chemical Physics》 - 2018,149(22) - 共14页 - 被引量：9

摘要：We investigate bulk structural properties of tetravalent associating particles within the framework of classical density functional theory, building uponWertheim's thermodynamic perturbation theory. T...

Stopper, Daniel |  Roth, Roland -  《The Journal of Chemical Physics》 - 2017,147(6) - 共12页 - 被引量：26

摘要：In this paper, we discuss the ability to numerically minimize the grand potential of hard disks in two-dimensional and of hard spheres in three-dimensional space within the framework of classical dens...