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1. Synthesis of (+)-Darwinolide, a Biofilm-Penetrating Anti-MRSA Agent NSTL国家科技图书文献中心

Siemon, Thomas |  Steinhauer, Simon... -  《Angewandte Chemie》 - 2019,58(4) - 1120~1122 - 共3页 - 被引量:15

摘要:Darwinolide, a recently identified marine natural product from the Antarctic sponge Dendrilla membranosa, was previously shown to exhibit promising activity against the biofilm phase of methicillin-re...
关键词: antibiotics |  darwinolide |  marine natural products |  terpenoids |  total synthesis

2. Mechanistic Characterisation of Two Sesquiterpene Cyclases from the Plant Pathogenic Fungus Fusarium fujikuroi NSTL国家科技图书文献中心

Burkhardt, Immo |  Siemon, Thomas... -  《Angewandte Chemie》 - 2016,55(30) - 8748~8751 - 共4页 - 被引量:41

摘要:Two sesquiterpene cyclases from Fusarium fujikuroi were expressed in Escherichia coli and purified. The first enzyme was inactive because of a critical mutation, but activity was restored by sequence ...
关键词: enzyme mechanisms |  Fusarium fujikuroi |  isotopic labelling |  NMR spectroscopy |  terpenes

3. Semisynthesis of Plant-Derived Englerin A Enabled by Microbe Engineering of Guaia-6,10(14)-diene as Building Block SCOPUS Scopus数据库 SCIE Web of Science核心 EI 工程索引 NSTL国家科技图书文献中心

Siemon, Thomas |  Wang, Zhangqian... -  《Journal of the American Chemical Society》 - 2020,142(6) - 2760~2765 - 共6页 - 被引量:31

摘要:Herein, we report a short semisynthesis of the potent transient receptor potential canonical (TRPC) channel agonist englerin A (EA) and the related guaianes oxyphyllol and orientalol E. The guaia-6,10...

4. Mechanistic Characterisation of Two Sesquiterpene Cyclases from the Plant Pathogenic Fungus Fusarium fujikuroi

Burkhardt, Immo |  Siemon, Thomas... -  《angewandte chemie-international edition》 - 2016,55(30) - 8748~8751 - 共4页

摘要:Two sesquiterpene cyclases from Fusarium fujikuroi were expressed in Escherichia coli and purified. The first enzyme was inactive because of a critical mutation, but activity was restored by sequence ...
关键词: enzyme mechanisms |  Fusarium fujikuroi |  isotopic labelling |  NMR spectroscopy |  terpenes |  GENE-CLUSTER |  NATURAL-PRODUCTS |  BIOSYNTHESIS |  SYNTHASE |  STEREOCHEMISTRY...
检索条件作者:Siemon, Thomas

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