Siemon, Thomas |  Steinhauer, Simon... -  《Angewandte Chemie》 - 2019,58(4) - 1120～1122 - 共3页 - 被引量：15

摘要：Darwinolide, a recently identified marine natural product from the Antarctic sponge Dendrilla membranosa, was previously shown to exhibit promising activity against the biofilm phase of methicillin-re...

关键词： antibiotics |  darwinolide |  marine natural products |  terpenoids |  total synthesis

Burkhardt, Immo |  Siemon, Thomas... -  《Angewandte Chemie》 - 2016,55(30) - 8748～8751 - 共4页 - 被引量：41

摘要：Two sesquiterpene cyclases from Fusarium fujikuroi were expressed in Escherichia coli and purified. The first enzyme was inactive because of a critical mutation, but activity was restored by sequence ...

关键词： enzyme mechanisms |  Fusarium fujikuroi |  isotopic labelling |  NMR spectroscopy |  terpenes

Siemon, Thomas |  Wang, Zhangqian... -  《Journal of the American Chemical Society》 - 2020,142(6) - 2760～2765 - 共6页 - 被引量：32

摘要：Herein, we report a short semisynthesis of the potent transient receptor potential canonical (TRPC) channel agonist englerin A (EA) and the related guaianes oxyphyllol and orientalol E. The guaia-6,10...

Burkhardt, Immo |  Siemon, Thomas... -  《angewandte chemie-international edition》 - 2016,55(30) - 8748～8751 - 共4页

摘要：Two sesquiterpene cyclases from Fusarium fujikuroi were expressed in Escherichia coli and purified. The first enzyme was inactive because of a critical mutation, but activity was restored by sequence ...

关键词： enzyme mechanisms |  Fusarium fujikuroi |  isotopic labelling |  NMR spectroscopy |  terpenes |  GENE-CLUSTER |  NATURAL-PRODUCTS |  BIOSYNTHESIS |  SYNTHASE |  STEREOCHEMISTRY...