NSTL国家科技图书文献中心

1. Prospects for Disease Slowing in Parkinson Disease NSTL国家科技图书文献中心

Menozzi, Elisa | Schapira, Anthony H.... - 《Annual Review of Pharmacology and Toxicology》 - 2025,65 - 237～258 - 共22页

摘要：The increasing prevalence of Parkinson disease (PD) highlights the need to develop interventions aimed at slowing or halting its progression. As a result of sophisticated disease modeling in preclinic...

关键词： Parkinson disease | disease progression | disease modifying | c-synuclein | genetics | α-synuclein

2. The Gut Microbiota in Parkinson Disease: Interactions with Drugs and Potential for Therapeutic Applications NSTL国家科技图书文献中心

Menozzi, Elisa | Schapira, Anthony H.... - 《CNS drugs》 - 2024,38(5) - 315～331 - 共17页 - 被引量：4

摘要：The concept of a 'microbiota-gut-brain axis' has recently emerged as an important player in the pathophysiology of Parkinson disease (PD), not least because of the reciprocal interaction between gut b...

关键词： INTESTINAL BACTERIAL OVERGROWTH | HELICOBACTER-PYLORI INFECTION | INTERNATIONAL SCIENTIFIC ASSOCIATION | L-DOPA ABSORPTION | ALPHA-SYNUCLEIN | DOUBLE-BLIND | CONSENSUS STATEMENT | LEVODOPA ABSORPTION | MOTOR FLUCTUATIONS | PROBIOTICS

3. Identification of novel glucocerebrosidase chaperones by unexpected skeletal rearrangement reaction NSTL国家科技图书文献中心

Takeda, Kunitoshi | Watanabe, Toru ... - 《Bioorganic and Medicinal Chemistry Letters》 - 2023,96 - 129531～129531 - 共6页

摘要：Compound 5 was identified from a high-throughput screening campaign as a small molecule pharmacological chaperone of glucocerebrocidase (GCase), a lysosomal hydrolase encoded by the GBA1 gene, variant...

关键词： Glucocerebrosidase | Pharmacological chaperone | Parkinson disease | Gaucher disease | Rearrangement reaction | GAUCHER-DISEASE

4. Retinal Optical Coherence Tomography Features Associated With Incident and Prevalent Parkinson Disease NSTL国家科技图书文献中心

Wagner, Siegfried Ka... | Romero-Bascones, Dav...... - 《Neurology.》 - 2023,101(16) - E1581～E1593 - 共13页 - 被引量：18

摘要：Background and ObjectivesCadaveric studies have shown disease-related neurodegeneration and other morphological abnormalities in the retina of individuals with Parkinson disease (PD); however, it rema...

关键词： SLEEP BEHAVIOR DISORDER | MULTIPLE-SCLEROSIS | DOPAMINE | RECOMMENDATIONS | DEGENERATION | PROGRESSION | MODEL

5. Bile acids and neurological disease NSTL国家科技图书文献中心

Hurley, Michael J. | Bates, Rachel ... - 《Pharmacology and Therapeutics: The Journal of the International Encyclopedia of Pharmacology and Therapeutics》 - 2022,240 - 108311～108311 - 共8页 - 被引量：18

摘要：This review will focus on how bile acids are being used in clinical trials to treat neurological diseases due to their central involvement with the gut-liver-brain axis and their physiological and pat...

关键词： Bile acids | Parkinson's disease | Neurodegeneration | Microbiome | FARNESOID-X-RECEPTOR | CENTRAL-NERVOUS-SYSTEM | BLOOD-BRAIN-BARRIER | VITAMIN-D-RECEPTOR | NUCLEAR RECEPTOR | PARKINSONS-DISEASE...

6. Glucocerebrosidase mutations and synucleinopathies: Toward a model of precision medicine SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Blandini, Fabio | Cilia, Roberto ... - 《Movement disorders》 - 2019,34(1) - 9～21 - 共13页 - 被引量：50

摘要：Glucocerebrosidase is a lysosomal enzyme. The characterization of a direct link between mutations in the gene coding for glucocerebrosidase (GBA1) with the development of Parkinson's disease and demen...

关键词： alpha-synuclein | GBA1 | GCase | Lewy bodies | Parkinson's disease

7. Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Watson, Lisa | Keatinge, Marcus ... - 《Neurobiology of disease》 - 2019,127 - 563～569 - 共7页 - 被引量：7

摘要：Bi-allelic mutations in the glucocerebrosidase gene (GBA1) cause Gaucher's disease, the most common human lysosomal storage disease. We previously reported a marked increase in miR-155 transcript leve...

关键词： Neuroinflammation | miR-155 | Zebrafish | Gaucher's disease | Parkinson's disease | Neurodegeneration

8. Insights into the structural biology of Gaucher disease SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Smith, Laura | Mullin, Stephen ... - 《Experimental Neurology》 - 2017,298(Pt.B) - 180～190 - 共11页 - 被引量：32

摘要：Gaucher disease, the most common lysosomal storage disorder, is caused by mutations in the gene encoding the acid-beta-glucosidase lysosomal hydrolase enzyme that cleaves glucocerebroside into glucose...

关键词： Glueocerebrosidase | Parkinson disease | Protein structure | Lysosome | Alpha-synuclein

9. Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Migdalska-Richards, ... | Ko, Wai Kin D.... - 《Synapse》 - 2017,71(7) - 共3页 - 被引量：61

摘要：Mutations in the glucocerebrosidase 1 (GBA1) gene are related to both Parkinson disease (PD) and Gaucher disease (GD). In both cases, the condition is associated with deficiency of glucocerebrosidase ...

关键词： ambroxol | glucocerebrosidase | Parkinson disease | nonhuman primate

10. The relationship between glucocerebrosidase mutations and Parkinson disease SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Migdalska-Richards, ... | Schapira, Anthony H.... - 《Journal of neurochemistry.》 - 2016,139(Suppl.1) - 77～90 - 共14页 - 被引量：108

摘要：Parkinson disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease, whereas Gaucher disease (GD) is the most frequent lysosomal storage disorder caused by homozygous m...