NSTL国家科技图书文献中心

1. A functional assay using human whole blood and flow cytometry analysis to evaluate cytotoxicity and immunomodulatory effect of anti-Trypanosoma cruzi drugs NSTL国家科技图书文献中心

Lopes, Mariana Eduar... | Ribeiro, Juliana M.... - 《Experimental parasitology》 - 2023,247 - ARTN 108490～ - 共8页 - 被引量：1

摘要：The discovery and development of new drugs for the treatment of Chagas disease is urgent due to the high toxicity and low cure efficacy, mainly during the chronic phase of this disease. Other chemothe...

关键词： Chagas disease | Trypanosoma cruzi | Whole blood | Flow cytometry | Cytokines | Chemokines | CHAGAS-DISEASE | ETIOLOGIC TREATMENT | IN-VITRO | BENZNIDAZOLE...

2. Novel 2-Nitroimidazole and Imidazooxazole Derivatives and their Activity against Trypanosoma cruzi and Mycobacterium tuberculosis SCIE Web of Science核心 NSTL国家科技图书文献中心

Faria, Jessica V. | Passos, Fernanda P. ...... - 《Medicinal chemistry》 - 2022,18(6) - 701～709 - 共9页 - 被引量：5

摘要：Background: Tuberculosis (TB) is one of the top ten causes of death worldwide, while Chagas disease (CD) is the parasitic disease that kills the largest number of people in the Americas. TB is the lea...

关键词： Chagas disease | tuberculosis | nitroimidazole | 1H-1 | 2 | 3-triazole | imidazooxazole | Trypanosoma cruzi | Mycobacterium tuberculosis | DRUG DISCOVERY...

3. Synthesis, Antitrypanosomal and Antimycobacterial Activities of Coumarin N-acylhydrazonic Derivatives SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Capelini, Camila | Camara, Vitoria R. F...... - 《Medicinal chemistry》 - 2021,17(6) - 630～637 - 共8页 - 被引量：3

摘要：Background: Near to 5-7 million people are infected with T. cruzi in the world, and about 10,000 people per year die of problems associated with this disease.

关键词： Antitrypanosomal | antimycobacterial | coumarine | N-Acylhydrazone | chagas | tuberculosis

4. Cultivable fungi present in Antarctic soils: taxonomy, phylogeny, diversity, and bioprospecting of antiparasitic and herbicidal metabolites SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Gomes, Eldon C. Q. | Godinho, Valeria M.... - 《Extremophiles: Life under extreme conditions》 - 2018,22(3) - 381～393 - 共13页 - 被引量：35

摘要：Molecular biology techniques were used to identify 218 fungi from soil samples collected from four islands of Antarctica. These consisted of 22 taxa of 15 different genera belonging to the Zygomycota,...

关键词： Antarctica | Fungi | Neglected tropical diseases | Mortierella | Pseudogymnoascus

5. Ornithine decarboxylase or gamma-glutamylcysteine synthetase overexpression protects Leishmania (Vianna) guyanensis against antimony SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Fonseca, Maisa S. | Comini, Marcelo A.... - 《Experimental parasitology》 - 2017,177 - 36～43 - 共8页 - 被引量：9

摘要：Trypanosomatids present a unique mechanism for detoxification of peroxides that is dependent on trypanothione (bisglutathionylspermidine). Ornithine decarboxylase (ODC) and gamma-glutamylcysteine synt...

关键词： Leishmania guyanensis | Ornithine decarboxylase | Gamma-glutamylcysteine synthetase | Antimony-resistance | Trypanothione

6. Novel gold(I) complexes with 5-phenyl-1,3,4-oxadiazole-2-thione and phosphine as potential anticancer and antileishmanial agents SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Chaves, Joana Darc S... | Tunes, Luiza Guimara...... - 《European Journal of Medicinal Chemistry: Chimie Therapeutique》 - 2017,127 - 727～739 - 共13页 - 被引量：49

摘要：The current anticancer and antileishmanial drug arsenal presents several limitations concerning their specificity, efficacy, costs and the emergence of drug-resistant cells lines, which encourages the...

关键词： Gold(I) complexes | 5-Phenyl-1 | 3 | 4-oxadiazole-2-thione | Antitumor activity | Antileishmania

7. Molecular characterization and functional analysis of pteridine reductase in wild-type and antimony-resistant Leishmania lines SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Moreira, Douglas de ... | Ferreira, Rafael Fer...... - 《Experimental parasitology》 - 2016,160 - 60～66 - 共7页 - 被引量：13

摘要：Pteridine reductase (PTR1) is an NADPH-dependent reductase that participates in the salvage of pteridines, which are essential to maintain growth of Leishmania. In this study, we performed the molecul...

关键词： Pteridine reductase | Leishmania | Drug resistance | ShIII | Antioxidant defense

8. Biological activities of ophiobolin K and 6-epi-ophiobolin K produced by the endophytic fungus Aspergillus calidoustus SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

de Carvalho, Camila ... | Almeida Vieira, Mari...... - 《Natural product research》 - 2016,30(4/6) - 478～481 - 共4页 - 被引量：15

摘要：Endophytic fungi represent ubiquitous microbial organisms able to live in the tissues of different plants around the world and represent a prolific source of bioactive metabolites. In the present stud...

关键词： cancer | endophytic fungi | Chagas' disease | secondary metabolites

9. Antibacterial, antifungal and antiprotozoal activities of fungal communities present in different substrates from Antarctica NSTL国家科技图书文献中心

Goncalves, Vivian N. | Carvalho, Camila R.... - 《Polar Biology》 - 2015,38(8) - 1143～1152 - 共10页 - 被引量：41

摘要：Antarctica is a pristine and extreme environment that represents a unique opportunity for taxonomic, ecological and biotechnological studies of the microorganisms. In the present work, the fungal comm...

关键词： Antarctica | Bioprospecting | Extremophiles | Fungi

10. Molecular phylogeny, diversity, symbiosis and discover of bioactive compounds of endophytic fungi associated with the medicinal Amazonian plant Carapa guianensis Aublet (Meliaceae) SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Ferreira, Mariana Co... | Almeida Vieira, Mari...... - 《Biochemical Systematics and Ecology》 - 2015,59 - 36～44 - 共9页 - 被引量：29

摘要：We investigated the endophytic fungal community associated with the Amazonian medicinal plant Carapa guianensis and its potential for providing bioactive compounds. A total of 162 endophytic fungal is...