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1. Platelet-derived growth factor receptor alpha/glial fibrillary acidic protein expressing peritumoral astrocytes associate with shorter median overall survival in glioblastoma patients SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Leiss, Lina | Mega, Alessandro ... - 《Glia》 - 2020,68(5) - 979～988 - 共10页 - 被引量：1

摘要：The microenvironment and architecture of peritumoral tissue have been suggested to affect permissiveness for infiltration of malignant cells. Astrocytes constitute a heterogeneous population of cells ...

关键词： astrocyte | biomarker | cell subset | glioblastoma | PDGFR alpha | tumor microenvironment

2. Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/beta-catenin signalling NSTL国家科技图书文献中心

Han, Mingzhi | Wang, Shuai ... - 《Brain: A journal of neurology》 - 2020,143(Pt.2) - 512～530 - 共19页 - 被引量：69

摘要：Long non-coding RNAs play critical roles in tumour progression. Through analysis of publicly available genomic datasets, found that MIR22HG, the host gene of microRNAs miR-22-3p and miR-22-Sp, is rank...

关键词： glioblastoma | lncRNA | miRNA | Wnt/beta-catenin signalling | small-molecule inhibitor

3. Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Golebiewska, Anna | Hau, Ann-Christin ... - 《Acta Neuropathologica》 - 2020,140(6) - 919～949 - 共31页 - 被引量：51

摘要：Patient-based cancer models are essential tools for studying tumor biology and for the assessment of drug responses in a translational context. We report the establishment a large cohort of unique org...

关键词： Glioma | Glioblastoma | Glioma recurrence | Patient-derived orthotopic xenograft | Organoid | Preclinical models | Precision medicine | IDH1 | MGMT | VAL-083

4. Mitochondrial DNA depletion in sporadic inclusion body myositis SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Bhatt, Padmanabh S. | Tzoulis, Charalampos ... - 《Neuromuscular disorders: NMD》 - 2019,29(3) - 242～246 - 共5页 - 被引量：5

摘要：Sporadic inclusion body myositis (sIBM) is a late onset disorder of unkown aetiology. Mitochondrial changes such as cytochrome oxidase deficient fibres are a well recognised feature and mitochondrial ...

关键词： Sporadic inclusion body myositis | Mitochondrial DNA depletion | Mitochondrial DNA deletion | Necrotising myopathy

5. Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Hossain, Jubayer A. | Latif, Md A.... - 《Neuro-oncology》 - 2019,21(7) - 890～900 - 共11页 - 被引量：16

摘要：Background Suicide gene therapy for malignant gliomas has shown encouraging results in the latest clinical trials. However, prodrug application was most often restricted to short-term treatment (14 da...

关键词： brain tumors | EGFR | glioblastoma | lentiviral vectors | suicide gene therapy

6. Genetic landscape of sporadic vestibular schwannoma SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Havik, Aril Loge | Bruland, Ove ... - 《Journal of neurosurgery.》 - 2018,128(3) - 911～922 - 共12页 - 被引量：27

摘要：OBJECTIVE Vestibular schwannoma (VS) is a benign tumor with associated morbidities and reduced quality of life. Except for mutations in NF2, the genetic landscape of VS remains to be elucidated. Littl...

关键词： vestibular schwannoma | NF2 | axonal guidance | next-generation sequencing | molecular biology | USP8 | CDC27

7. EGFR heterogeneity and implications for therapeutic intervention in glioblastoma SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Eskilsson, Eskil | Rosland, Gro V.... - 《Neuro-oncology》 - 2018,20(6) - 743～752 - 共10页 - 被引量：132

摘要：Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need of effective treatment strategies. Recent advances in sequencing techniques unraveled the complete genomic lan...

关键词： angiogenesis | EGFR | glioblastoma | invasion | targeted therapy | tumor heterogeneity

8. Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Aldape, Kenneth | Amin, Samirkumar B.... - 《Neuro-oncology》 - 2018,20(7) - 873～884 - 共12页 - 被引量：85

摘要：Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensi...

关键词： characterization | evolution | glioma | sequencing | subtypes

9. The angiogenic switch leads to a metabolic shift in human glioblastoma SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Talasila, Krishna M. | Rosland, Gro V.... - 《Neuro-oncology》 - 2017,19(3) - 383～393 - 共11页 - 被引量：20

摘要：Background. Invasion and angiogenesis are major hallmarks of glioblastoma (GBM) growth. While invasive tumor cells grow adjacent to blood vessels in normal brain tissue, tumor cells within neovascular...

关键词： angiogenesis | glioblastoma | glycolysis | hypoxia | invasion

10. Lentiviral HSV-Tk.007-mediated suicide gene therapy is not toxic for normal brain cells NSTL国家科技图书文献中心

Hossain, Jubayer A. | Ystaas, Lars Romo ... - 《The journal of gene medicine》 - 2016,18(9) - 234～243 - 共10页 - 被引量：4

摘要：Background Gene therapeutic strategies with suicide genes are currently investigated in clinical trials for brain tumors. Previously, we have shown that lentiviral vectors delivering the suicide gene ...