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1. CP204L Is a Multifunctional Protein of African Swine Fever Virus That Interacts with the VPS39 Subunit of the Homotypic Fusion and Vacuole Protein Sorting Complex and Promotes Lysosome Clustering NSTL国家科技图书文献中心

Dolata, Katarzyna Ma... | Fuchs, Walter ... - 《Journal of Virology》 - 2023,97(2) - 共20页 - 被引量：5

摘要：African swine fever virus (ASFV) was first identified over a hundred years ago. Since then, much effort has been made to understand the pathogenesis of ASFV. Virus replication depends on a complex int...

关键词： African swine fever virus | ASFV | CP204L | VPS39 | HOPS complex | virus-host interaction | lysosomes | HOPS COMPLEX | MEMBRANE | SEQUENCE...

2. Investigating Environmental Matrices for Use in Avian Influenza Virus Surveillance-Surface Water, Sediments, and Avian Fecal Samples NSTL国家科技图书文献中心

Ahrens, Ann Kathrin | Selinka, Hans-Christ...... - 《Microbiology Spectrum》 - 2023,11(2) - 共16页 - 被引量：4

摘要：Avian influenza viruses (AIV) have a wide host range in the avian metapopulation and, occasionally, transmission to humans also occurs. Surface water plays a particularly important role in the epidemi...

关键词： avian influenza | surveillance | surface water | sediment | environment | filtration | feces | WILD BIRDS | RT-PCR | PERSISTENCE...

3. Genetic Determinants for Virulence and Transmission of the Panzootic Avian Influenza Virus H5N8 Clade 2.3.4.4 in Pekin Ducks SCIE Web of Science核心 NSTL国家科技图书文献中心

Scheibner, David | Breithaupt, Angele ... - 《Journal of Virology》 - 2022,96(13) - 共18页 - 被引量：6

摘要：Since 2014, several waves of avian influenza virus (AIV) H5N8 of clade 2.3.4.4 occurred globally on unprecedented levels. Unlike viruses in the first wave in 2014-2015 (H5N8-A), viruses in 2015-2016 (...

关键词： HPAI | hemagglutinin | virulence determinants | ducks | nucleoprotein | neuramindase | non-structural protein NS1 | highly pathogenic avian influenza virus | NS1 PROTEIN | HEMAGGLUTININ CLEAVAGE...

4. Evidence for Different Virulence Determinants and Host Response after Infection of Turkeys and Chickens with Highly Pathogenic H7N1 Avian Influenza Virus SCIE Web of Science核心 NSTL国家科技图书文献中心

Blaurock, Claudia | Pfaff, Florian ... - 《Journal of Virology》 - 2022,96(17) - 共25页 - 被引量：5

摘要：Wild birds are the reservoir for all avian influenza viruses (AIV). In poultry, the transition from low pathogenic (LP) AIV of H5 and H7 subtypes to highly pathogenic (HP) AIV is accompanied mainly by...

关键词： virulence determinants | avian influenza virus | high pathogenicity | turkeys | chickens | cleavage site | glycosylation | transcriptome | host response | CLEAVAGE SITE...

5. Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs NSTL国家科技图书文献中心

Kurtz, Stefanie | Lucas-Hahn, Andrea ... - 《Proceedings of the National Academy of Sciences of the United States of America.》 - 2021,118(2) - e2008743118～e2008743118 - 共9页 - 被引量：14

摘要：The sex-determining region on the Y chromosome (SRY) is thought to be the central genetic element of male sex development in mammals. Pathogenic modifications within the SRY gene are associated with a...

关键词： porcine SRY gene | sex reversal | CRISPR/Cas9 | RNPs | HMG domain | MAMMALIAN SEX | MOLECULAR-MECHANISMS | X-INACTIVATION | Y-CHROMOSOME | EVOLUTION...

6. Pitfalls in SARS-CoV-2 PCR diagnostics SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Wernike, Kerstin | Keller, Markus ... - 《Transboundary and emerging diseases》 - 2021,68(2) - 253～257 - 共5页 - 被引量：23

摘要：To combat the COVID-19 pandemic, millions of PCR tests are performed worldwide. Any deviation of the diagnostic sensitivity and specificity will reduce the predictive values of the test. Here, we repo...

关键词： contamination | coronavirus | COVID-19 | diagnostics | pooling | real-time PCR | swab

7. T-cell responses in domestic pigs and wild boar upon infection with the moderately virulent African swine fever virus strain 'Estonia2014' SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Schaefer, Alexander | Zani, Laura ... - 《Transboundary and emerging diseases》 - 2021,68(5) - 2733～2749 - 共17页 - 被引量：4

摘要：Infection with African swine fever virus (ASFV) causes a highly lethal haemorrhagic disease in domestic and Eurasian wild pigs. Thus, it is a major threat to pig populations worldwide and a cause of s...

关键词： African swine fever virus | domestic pig | experimental infection | iNKT cells | T& | 8208 | cell response | wild boar

8. Preferential Selection and Contribution of Non-Structural Protein 1 (NS1) to the Efficient Transmission of Panzootic Avian Influenza H5N8 Virus Clades 2.3.4.4A and B in Chickens and Ducks SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Blaurock, Claudia | Breithaupt, Angele ... - 《Journal of Virology》 - 2021,95(18) - ARTN e00445-21～ - 共17页 - 被引量：4

摘要：Highly pathogenic avian influenza virus H5N8 clade 2.3.4.4 caused outbreaks in poultry at an unprecedented global scale. The virus was spread by wild birds in Asia in two waves: clade 2.3.4.4A in 2014...

关键词： highly pathogenic avian influenza virus | H5N8 | clade 2.3.4.4 | evolution | NS1 | virulence | transmission | ducks | interferon antagonism | INNATE IMMUNE-RESPONSES...

9. Diazadispiroalkane Derivatives Are new Viral Entry Inhibitors SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Adfeldt, Rebekka | Schmitz, Janna ... - 《Antimicrobial agents and chemotherapy.》 - 2021,65(4) - 共12页 - 被引量：5

摘要：Herpesviruses are widespread and can cause serious illness. Many currently available antiviral drugs have limited effects, result in rapid development of resistance, and often exhibit dose-dependent t...

关键词： antiviral activity | entry inhibitors | heparan sulfate binding | human cytomegalovirus | new mode of action | pseudorabies virus | virus attachment

10. Influenza A H1N1 Induced Disturbance of the Respiratory and Fecal Microbiome of German Landrace Pigs - a Multi-Omics Characterization SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Gierse, Laurin Chris... | Meene, Alexander ... - 《Microbiology Spectrum》 - 2021,9(2) - ARTN e00182-21～ - 共17页 - 被引量：10

摘要：Seasonal influenza outbreaks represent a large burden for the health care system as well as the economy. While the role of the microbiome has been elucidated in the context of various diseases, the im...

关键词： 16S rRNA gene sequencing | influenza A | microbiome | biomedical model swine | metabolomics | metaproteomics | multi-omics | CHAIN FATTY-ACIDS | DIFFERENTIAL EXPRESSION ANALYSIS | BICINCHONINIC ACID...