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1. Increases in cytosolic Ca2+ induce dynamin- and calcineurin-dependent internalisation of CFTR SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Patel, Waseema | Moore, Patrick J.... - 《Cellular and molecular life sciences: CMLS》 - 2019,76(5) - 977～994 - 共18页 - 被引量：10

摘要：The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated, apical anion channel that regulates ion and fluid transport in many epithelia including the airways. We have previou...

关键词： CFTR | Calcium | Cigarette smoke | Calcineurin

2. Cigarette smoke modifies and inactivates SPLUNC1, leading to airway dehydration SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Moore, Patrick J. | Reidel, Boris ... - 《The FASEB Journal》 - 2018,32(12) - 6559～6574 - 共16页 - 被引量：7

摘要：Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality worldwide. Cigarette smoke (CS) exposure, a major cause of COPD, dysregulates airway epithelial ion transport...

关键词： BPIFA1 | -unsaturated aldehydes | airway surface liquid | ENaC | COPD

3. Dual oxic-anoxic co-culture enables direct study of anaerobe-host interactions at the airway epithelial interface

Moore, Patrick J. | Hoffman, Kayla ... - 《MBio》 - 2025,16(5) - 共22页

摘要：Strict and facultative anaerobic bacteria are widely associated with both acute and chronic airway diseases. However, their potential role(s) in disease pathophysiology remains poorly understood due t...

关键词： Fusobacterium nucleatum | airway epithelium | RNAseq | single-cell RNA sequencing | CHAIN FATTY-ACIDS | FUSOBACTERIUM-NUCLEATUM | PSEUDOMONAS-AERUGINOSA | PREVOTELLA-INTERMEDIA | BINDING-PROTEIN | ORAL BACTERIA...

4. Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

Fiege, Jessica K. | Thiede, Joshua M.... - 《plos pathogens》 - 2021,17(1) - 共15页 - 被引量：42

摘要：The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how the heterogeneity of this diverse cell population contr...

关键词： DYNAMICS

5. Tobacco exposure inhibits SPLUNC1-dependent antimicrobial activity

Moore, Patrick J. | Sesma, Juliana ... - 《Respiratory Research》 - 2019,20 - 共11页 - 被引量：4

摘要：BackgroundTobacco smoke exposure impairs the lung's innate immune response, leading to an increased risk of chronic infections. SPLUNC1 is a secreted, multifunctional innate defense protein that has a...

关键词： Sputum | COPD | Little cigars | BPIFA1 | OBSTRUCTIVE PULMONARY-DISEASE | CIGARETTE-SMOKE | HAEMOPHILUS-INFLUENZAE | LIPOPOLYSACCHARIDES | COLONIZATION | MECHANISMS...

6. Cigarette Smoke Exposure Induces Retrograde Trafficking of CFTR to the Endoplasmic Reticulum

Marklew, Abigail J. | Patel, Waseema ... - 《scientific reports》 - 2019,9 - 共17页 - 被引量：17

摘要：Chronic obstructive pulmonary disease (COPD), which is most commonly caused by cigarette smoke (CS) exposure, is the third leading cause of death worldwide. The cystic fibrosis transmembrane conductan...

关键词： TRANSMEMBRANE CONDUCTANCE REGULATOR | PLASMA-MEMBRANE | ENDOCYTIC TRAFFICKING | R-DOMAIN | PROTEIN | PHOSPHORYLATION | TRANSPORT | LUNG | CAMP | PATHOPHYSIOLOGY

7. Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease

Terryah, Shawn T. | Fellner, Robert C.... - 《American Journal of Physiology: Lung Cellular and Molecular Physiology (Print)》 - 2018,314(1) - L192～L205 - 共14页 - 被引量：19

摘要：In cystic fibrosis (CF) lungs, epithelial Na+ channel (ENaC) hyperactivity causes a reduction in airway surface liquid volume, leading to decreased mucocilliary clearance, chronic bacterial infection,...

关键词： SURFACE LIQUID VOLUME | ENAC-OVEREXPRESSING MICE | MUCUS TRANSPORT RATES | SODIUM-CHANNEL ENAC | EPITHELIAL CLONE 1 | MUCOCILIARY CLEARANCE | ENERGY-EXPENDITURE | AIRWAY HYDRATION | CELL-CULTURES | HUMAN SPLUNC1

8. Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor

Wu, Tongde | Huang, Julianne ... - 《nature communications》 - 2017,8 - 共10页

摘要：
Asthma is a chronic airway disease characterized by inflammation, mucus hypersecretion and abnormal airway smooth muscle (ASM) contraction. Bacterial permeability family ...

摘要：The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated, apical anion channel that regulates ion and fluid transport in many epithelia including the airways. We have previou...

关键词： CFTR | Calcium | Cigarette smoke | Calcineurin

摘要：Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality worldwide. Cigarette smoke (CS) exposure, a major cause of COPD, dysregulates airway epithelial ion transport...

关键词： BPIFA1 | -unsaturated aldehydes | airway surface liquid | ENaC | COPD

摘要：Strict and facultative anaerobic bacteria are widely associated with both acute and chronic airway diseases. However, their potential role(s) in disease pathophysiology remains poorly understood due t...

关键词： Fusobacterium nucleatum | airway epithelium | RNAseq | single-cell RNA sequencing | CHAIN FATTY-ACIDS | FUSOBACTERIUM-NUCLEATUM | PSEUDOMONAS-AERUGINOSA | PREVOTELLA-INTERMEDIA | BINDING-PROTEIN | ORAL BACTERIA...

摘要：The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how the heterogeneity of this diverse cell population contr...

关键词： DYNAMICS

摘要：BackgroundTobacco smoke exposure impairs the lung's innate immune response, leading to an increased risk of chronic infections. SPLUNC1 is a secreted, multifunctional innate defense protein that has a...

关键词： Sputum | COPD | Little cigars | BPIFA1 | OBSTRUCTIVE PULMONARY-DISEASE | CIGARETTE-SMOKE | HAEMOPHILUS-INFLUENZAE | LIPOPOLYSACCHARIDES | COLONIZATION | MECHANISMS...

摘要：Chronic obstructive pulmonary disease (COPD), which is most commonly caused by cigarette smoke (CS) exposure, is the third leading cause of death worldwide. The cystic fibrosis transmembrane conductan...

关键词： TRANSMEMBRANE CONDUCTANCE REGULATOR | PLASMA-MEMBRANE | ENDOCYTIC TRAFFICKING | R-DOMAIN | PROTEIN | PHOSPHORYLATION | TRANSPORT | LUNG | CAMP | PATHOPHYSIOLOGY

摘要：In cystic fibrosis (CF) lungs, epithelial Na+ channel (ENaC) hyperactivity causes a reduction in airway surface liquid volume, leading to decreased mucocilliary clearance, chronic bacterial infection,...

关键词： SURFACE LIQUID VOLUME | ENAC-OVEREXPRESSING MICE | MUCUS TRANSPORT RATES | SODIUM-CHANNEL ENAC | EPITHELIAL CLONE 1 | MUCOCILIARY CLEARANCE | ENERGY-EXPENDITURE | AIRWAY HYDRATION | CELL-CULTURES | HUMAN SPLUNC1

摘要：
Asthma is a chronic airway disease characterized by inflammation, mucus hypersecretion and abnormal airway smooth muscle (ASM) contraction. Bacterial permeability family ...

关键词： OPERATED CA2+ ENTRY | CYSTIC-FIBROSIS | AIRWAY EPITHELIUM | CELLS | SPLUNC1 | RELEASE | INFLAMMATION | ASTHMA | PROTEINS | PLUNC

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated, apical anion channel that regulates ion and fluid transport in many epithelia including the airways. We have previou...

关键词： CFTR | Calcium | Cigarette smoke | Calcineurin

摘要：Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality worldwide. Cigarette smoke (CS) exposure, a major cause of COPD, dysregulates airway epithelial ion transport...

关键词： BPIFA1 | -unsaturated aldehydes | airway surface liquid | ENaC | COPD

摘要：Strict and facultative anaerobic bacteria are widely associated with both acute and chronic airway diseases. However, their potential role(s) in disease pathophysiology remains poorly understood due t...

关键词： Fusobacterium nucleatum | airway epithelium | RNAseq | single-cell RNA sequencing | CHAIN FATTY-ACIDS | FUSOBACTERIUM-NUCLEATUM | PSEUDOMONAS-AERUGINOSA | PREVOTELLA-INTERMEDIA | BINDING-PROTEIN | ORAL BACTERIA...

摘要：The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how the heterogeneity of this diverse cell population contr...

关键词： DYNAMICS

摘要：BackgroundTobacco smoke exposure impairs the lung's innate immune response, leading to an increased risk of chronic infections. SPLUNC1 is a secreted, multifunctional innate defense protein that has a...

关键词： Sputum | COPD | Little cigars | BPIFA1 | OBSTRUCTIVE PULMONARY-DISEASE | CIGARETTE-SMOKE | HAEMOPHILUS-INFLUENZAE | LIPOPOLYSACCHARIDES | COLONIZATION | MECHANISMS...

摘要：Chronic obstructive pulmonary disease (COPD), which is most commonly caused by cigarette smoke (CS) exposure, is the third leading cause of death worldwide. The cystic fibrosis transmembrane conductan...

关键词： TRANSMEMBRANE CONDUCTANCE REGULATOR | PLASMA-MEMBRANE | ENDOCYTIC TRAFFICKING | R-DOMAIN | PROTEIN | PHOSPHORYLATION | TRANSPORT | LUNG | CAMP | PATHOPHYSIOLOGY

摘要：In cystic fibrosis (CF) lungs, epithelial Na+ channel (ENaC) hyperactivity causes a reduction in airway surface liquid volume, leading to decreased mucocilliary clearance, chronic bacterial infection,...

关键词： SURFACE LIQUID VOLUME | ENAC-OVEREXPRESSING MICE | MUCUS TRANSPORT RATES | SODIUM-CHANNEL ENAC | EPITHELIAL CLONE 1 | MUCOCILIARY CLEARANCE | ENERGY-EXPENDITURE | AIRWAY HYDRATION | CELL-CULTURES | HUMAN SPLUNC1

摘要：Asthma is a chronic airway disease characterized by inflammation, mucus hypersecretion and abnormal airway smooth muscle (ASM) contraction. Bacterial permeability family ...

关键词： OPERATED CA2+ ENTRY | CYSTIC-FIBROSIS | AIRWAY EPITHELIUM | CELLS | SPLUNC1 | RELEASE | INFLAMMATION | ASTHMA | PROTEINS | PLUNC

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：
Asthma is a chronic airway disease characterized by inflammation, mucus hypersecretion and abnormal airway smooth muscle (ASM) contraction. Bacterial permeability family ...