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1. G3BP1, a stress granule core protein, ameliorates metabolic dysfunction-associated fatty liver disease by attenuating hepatocyte lipid deposition NSTL国家科技图书文献中心

Liu, Xingjing |  Yu, Huimei... -  《Diabetes, obesity & metabolism.》 - 2025,27(6) - 2985～2995 - 共11页

摘要：AimAbnormal lipid accumulation is an important cause of metabolic dysfunction-associated fatty liver disease (MAFLD) progression and can induce several stress responses within cells. This study is the...
关键词： APOC3 |  fatty acid |  G3BP1 |  Metabolic dysfunction-associated fatty liver disease |  stress granule |  Metabolic dysfunction‐associated fatty liver disease
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2. Astaxanthin reduces inflammation and promotes a chondrogenic phenotype by upregulating SIRT1 in osteoarthritis NSTL国家科技图书文献中心

Qin, Haonan |  Liu, Xingjing... -  《The Knee》 - 2024,48 - 83～93 - 共11页

摘要：Objective: To investigate the effects of astaxanthin (AST) on mouse osteoarthritis (OA) and lipopolysaccharide (LPS)-induced ATDC5 cell damage and to explore whether SIRT1 protein plays a role. Method...
关键词： Osteoarthritis |  Inflammation |  Astaxanthin |  SIRT1
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3. Specific Deletion of CASK in Pancreatic beta-Cells Affects Glucose Homeostasis and Improves Insulin Sensitivity in Obese Mice by Reducing Hyperinsulinemia SCIE Web of Science核心 NSTL国家科技图书文献中心

Liu, Xingjing |  Sun, Peng... -  《Diabetes: A Journal of the American Diabetes Association》 - 2022,71(1) - 104～115 - 共12页

摘要：Calcium/calmodulin-dependent serine protein kinase (CASK) is involved in the secretion of insulin vesicles in pancreatic beta-cells. The current study revealed a new in vivo role of CASK in glucose ho...
关键词： SERINE PROTEIN-KINASE |  PROMOTES OBESITY |  DOWN-REGULATION |  EXPRESSION |  RESISTANCE |  SECRETION |  LINKS
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4. CASK, APBA1, and STXBP1 collaborate during insulin secretion NSTL国家科技图书文献中心

Zhang, Kai |  Wang, Tianyuan... -  《Molecular and Cellular Endocrinology》 - 2021,520 - 共10页

摘要：Calcium/calmodulin-dependent serine protein kinase (CASK) knockdown reduces insulin vesicle docking to cell membranes. Here, we explored CASK interactions with other proteins during insulin secretion....
关键词： CASK |  APBA1 |  STXBP1 |  T2DM |  Insulin secretion
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5. STAT3-mediated upregulation of TRIM6 promotes hepatocellular carcinoma invasion through the DDX58-Snail1 axis

Wang, Yiqiao |  Wang, Jie... -  《scientific reports》 - 2025,15(1) - 共16页

摘要：Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with poor prognosis, driven by complex molecular mechanisms that remain inadequately understood. Among these, the ubiquitin-proteasome ...
关键词： Hepatocellular carcinoma |  TRIM6 |  E3 ubiquitin ligase |  STAT3 |  DDX58 |  Epithelial-mesenchymal transition (EMT) |  Metastasis |  PROGRESSION |  SNAIL |  EMT
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6. Tiaogan Bushen Xiaoji Formula Enhances the Sensitivity of Estrogen Receptor- Positive Breast Cancer to Tamoxifen by Inhibiting the TGF-β/SMAD Pathway

Lu, Jiafeng |  Li, Zhaoyan... -  《cancer management and research》 - 2024,16 - 1189～1204 - 共16页

摘要：Background: The resistance to endocrine therapy can lead to recurrence and metastasis of breast cancer (BC), affecting the survival period. Tiaogan Bushen Xiaoji (TGBSXJ) Formula, a traditional Chines...
关键词： estrogen receptor-positive breast cancer |  network pharmacology |  traditional Chinese medicine |  endocrine resistance |  MECHANISMS |  RESISTANCE |  TGF-BETA-1 |  CHEMORESISTANCE |  CADHERIN
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7. The biological functions and pathological mechanisms of CASK in various diseases

Liu, Xingjing |  Qin, Haonan... -  《Heliyon》 - 2024,10(8) - 共10页

摘要：Background: As a scaffold protein, calcium/calmodulin-dependent serine protein kinase (CASK) has been extensively studied in a variety of tissues throughout the body. The Cask gene is ubiquitous in se...
关键词： CASK |  Nervous system |  Diabetes |  Tumour |  Genetic mutations |  PANCREATIC BETA-CELLS |  SERINE PROTEIN-KINASE |  DOWN-REGULATION |  PROTEOMIC ANALYSIS |  INSULIN-SECRETION...
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