Leko, Maria |  Filippova, Polina... -  《Journal of peptide science》 - 2025,31(4) - 共8页

摘要：Peptide hydrazides are widely applied as precursors of peptide thioesters, valuable building blocks for the synthesis of proteins by native chemical ligation. In addition, they can be applied for the ...

关键词： CMR‐free protocols |  green chemistry |  peptide hydrazides |  SPPS |  CMR-free protocols

Chelushkin, Pavel S. |  Leko, Maria V.... -  《Journal of peptide science: An official publication of the European Peptide Society》 - 2017,23(1) - 13～15 - 共3页 - 被引量：3

摘要：Oxime ligation is a powerful tool in various bioconjugation strategies. Nevertheless, high reaction rates and quantitative yields are typically reported for aldehyde-derived compounds. In contrary, ke...

关键词： oxime ligation |  polymer-peptide conjugates |  peptide-steroids conjugates |  aminooxy-peptides

Akasov, Roman |  Zaytseva-Zotova, Dar...... -  《International Journal of Pharmaceutics》 - 2016,506(1/2) - 148～157 - 共10页 - 被引量：26

摘要：Development of novel anticancer formulations is a priority challenge in biomedicine. However, in vitro models based on monolayer cultures (2D) which are currently used for cytotoxicity tests leave muc...

关键词： Cell self-assembly |  Multicellular tumor spheroids |  Cyclic RGD-peptides |  Cytotoxicity |  Drug screening

Chelushkin, Pavel S. |  Polyanichko, Ksenia ...... -  《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 - 2015,56(4) - 619～622 - 共4页 - 被引量：9

摘要：Peptide hydrazides can be easily synthesized using a new hydrazone resin, obtained via acylation of aminomethyl polystyrene by Fmoc-hydrazone of pyruvic acid. It was shown that the hydrazone linker is...

关键词： Peptide hydrazides |  Solid-phase peptide synthesis |  Hydrazone resin |  Hydrazone ligation strategy

Bruckdorfer, Thomas |  Chelushkin, Pavel S.... -  《Journal of peptide science: An official publication of the European Peptide Society》 - 2018,24(S2) - S82～S82 - 共1页

Leko, Maria |  Pokhvoshcheva, Anna... -  《Journal of peptide science: An official publication of the European Peptide Society》 - 2018,24(S2) - S86～S87 - 共2页

Haq, Sabah |  Samuel, Vanessa... -  《oncotargets and therapy》 - 2017,10 - 2427～2447 - 共21页 - 被引量：4

摘要：Background: Prostaspheres-based three dimensional (3D) culture models have provided insight into prostate cancer (PCa) biology, highlighting the importance of cell-cell interactions and the extracellu...

关键词： PC3 and DU145 cell lines |  cadherin |  oseltamivir phosphate |  gemcitabine |  chemoresistance |  neuraminidase |  EMT |  spheroid |  PROSTATE-CANCER |  TUMOR SPHEROIDS...

Akasov, Roman |  Drozdova, Maria... -  《advanced pharmaceutical bulletin》 - 2017,7(4) - 593～601 - 共9页

摘要：Purpose: Multidrug resistance (MDR) of tumors to chemotherapeutics often leads to failure of cancer treatment. The aim of the study was to prepare novel MDR-overcoming chemotherapeutics based on doxor...

关键词： Aantitumor drug screening assays |  Microencapsulation |  Multicellular spheroids |  Multiple drug resistance |  Serum albumin |  MULTICELLULAR TUMOR SPHEROIDS |  ALBUMIN-BINDING PRODRUG |  DRUG-DELIVERY SYSTEMS |  MULTIDRUG-RESISTANCE |  ANTICANCER...