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1. Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis NSTL国家科技图书文献中心

Choi, You-Jin | Nam, Yoon Ah ... - 《Autophagy》 - 2025,21(4) - 827～839 - 共13页

摘要：SORT1 (sortilin 1), a member of the the Vps10 (vacuolar protein sorting 10) family, is involved in hepatic lipid metabolism by regulating very low-density lipoprotein (VLDL) secretion and facilitating...

关键词： Carboxylesterase 1 | chaperone-mediated autophagy | nonalcoholic fatty liver | sortilin 1 | triglyceride hydorolysis

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2. Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner NSTL国家科技图书文献中心

Lim, Jin Ju | Noh, Sujin ... - 《Autophagy》 - 2024,20(12) - 2752～2768 - 共17页

摘要：Aging is often accompanied by a decline in proteostasis, manifested as an increased propensity for misfolded protein aggregates, which are prevented by protein quality control systems, such as the ubi...

关键词： Autophagy | foxo | IU1 | proteostasis | ubiquitin-proteasome system | ubiquitin-specific peptidase 14

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3. Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense NSTL国家科技图书文献中心

Choi, Eun-Ji | Oh, Hyun-Taek ... - 《Autophagy》 - 2024,20(11) - 2490～2510 - 共21页

摘要：Co-occurring mutations in KEAP1 in STK11/LKB1-mutant NSCLC activate NFE2L2/NRF2 to compensate for the loss of STK11-AMPK activity during metabolic adaptation. Characterizing the regulatory crosstalk b...

关键词： AXIN | KEAP1 | lysosomal stress | metabolic stress | oxidative stress | STK11/LKB1

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4. Biallelic USP14 variants cause a syndromic neurodevelopmental disorder NSTL国家科技图书文献中心

Ebstein, Frederic | Latypova, Xenia ... - 《Genetics in medicine》 - 2024,26(6) - 101120～101120 - 共6页

摘要：Purpose: Imbalances in protein homeostasis affect human brain development, with the ubiquitin-proteasome system (UPS) and autophagy playing crucial roles in neurodevelopmental disorders (NDD). This st...

关键词： Loss-of-function variants | N-terminal methionine excision | Neurodevelopmental disorders | Ubiquitin-proteasome system | USP14 | DEUBIQUITINATING ENZYME | INTELLECTUAL DISABILITY | PROTEINS | UBIQUITINATION | ASSOCIATION...

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5. The role of SHMT2 in modulating lipid metabolism in hepatocytes via glycine-mediated mTOR activation SCIE Web of Science核心 NSTL国家科技图书文献中心

Choi, You-Jin | Lee, Geunhye ... - 《Amino acids》 - 2022,54(5) - 823～834 - 共12页 - 被引量：5

摘要：Serine hydroxymethyltransferase 2 (SHMT2) converts serine into glycine in the mitochondrial matrix, transferring a methyl group to tetrahydrofolate. SHMT2 plays an important role in the maintenance of...

关键词： SHMT2 | Glycine | Lipid metabolism | mTOR | PPAR gamma | FATTY LIVER-DISEASE | PPAR-GAMMA | HEPATIC LIPOGENESIS | GENE-EXPRESSION | HEPATOCELLULAR-CARCINOMA...

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6. Dislocation Structure in Hot Deformed Al-Zn-Mg Alloy by X-ray Line Profile Analysis NSTL国家科技图书文献中心

Lee, Gyeong-Seo | Kim, Sang-Wook ... - 《Journal of nanoscience and nanotechnology》 - 2020,20(1) - 177～182 - 共6页 - 被引量：1

摘要：The microstructure of extruded Cu-free Al-Zn-Mg alloy is studied. Hot torsion tests are performed on a Cu-free Al-Zn-Mg alloy to investigate the effect of large strain deformation on the dislocation b...

关键词： Al-Zn-Mg Alloy | Hot Torsion Test | X-ray Line Profile

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7. Protective effect of EX-527 against high-fat diet-induced diabetic nephropathy in Zucker rats NSTL国家科技图书文献中心

Kundu, Amit | Richa, Sachan ... - 《Toxicology and Applied Pharmacology》 - 2020,390 - 114899～114899 - 共5页 - 被引量：16

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High-fat diet (HFD)-induced obesity is implicated in diabetic nephropathy (DN). EX-527, a selective Sirtuin 1 (SIRT1) inhibitor, has multiple biological functions; howeve...

关键词： High-fat diet | Diabetic nephropathy | EX-527 | Inflammation | Oxidative stress | SIRT | GROWTH-FACTOR RECEPTOR | INTERSTITIAL FIBROBLAST ACTIVATION | INDUCED OXIDATIVE STRESS | INHIBITS RENAL FIBROSIS...

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8. Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Sim, Woo-Cheol | Lee, Wonseok ... - 《Metabolism: Clinical and Experimental》 - 2020,102 - 共10页 - 被引量：17

摘要：Objective: Supplementation with serine attenuates alcoholic fatty liver by regulating homocysteine metabolism and lipogenesis. However, little is known about scrine metabolism in fatty liver disease (...

关键词： 3-Phosphoglycerate dehydrogenase (PHGDH) | Serine | High-fat diet | Non-alcoholic fatty liver disease (NAFID) | NRF2 | SIRT1

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9. Activation of SIRT1 by l-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes (l-serine activates SIRT1 in C2C12 myotubes) SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Sim, Woo-Cheol | Kim, Dong Gwang ... - 《Cell Biology and Toxicology》 - 2019,35(5) - 457～470 - 共14页 - 被引量：16

摘要：Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, and the function is linked to cellular metabolism including mitochondrial biogenesis. Hepa...

关键词： Insulin resistance | l-Serine | Mitochondrial biogenesis | Nicotinamide adenine dinucleotide (NAD(+)) | Silent information regulator 1 (SIRT1)

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10. Hepatic upregulation of fetuin-A mediates acetaminophen-induced liver injury through activation of TLR4 in mice SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Lee, Kang-Yo | Lee, Wonseok ... - 《Biochemical Pharmacology》 - 2019,166 - 46～55 - 共10页 - 被引量：12

摘要：Acetaminophen (APAP)-induced liver injury (AILI) is initiated by the generation of a reactive metabolite and ultimately leads to hepatocyte necrosis. Necrotic cells secrete damage-associated molecular...

关键词： Acetaminophen | Fetuin-A | Hepatokine | Chemokine | Hepatotoxicity

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摘要：SORT1 (sortilin 1), a member of the the Vps10 (vacuolar protein sorting 10) family, is involved in hepatic lipid metabolism by regulating very low-density lipoprotein (VLDL) secretion and facilitating...

关键词： Carboxylesterase 1 | chaperone-mediated autophagy | nonalcoholic fatty liver | sortilin 1 | triglyceride hydorolysis

摘要：Aging is often accompanied by a decline in proteostasis, manifested as an increased propensity for misfolded protein aggregates, which are prevented by protein quality control systems, such as the ubi...

关键词： Autophagy | foxo | IU1 | proteostasis | ubiquitin-proteasome system | ubiquitin-specific peptidase 14

摘要：Co-occurring mutations in KEAP1 in STK11/LKB1-mutant NSCLC activate NFE2L2/NRF2 to compensate for the loss of STK11-AMPK activity during metabolic adaptation. Characterizing the regulatory crosstalk b...

关键词： AXIN | KEAP1 | lysosomal stress | metabolic stress | oxidative stress | STK11/LKB1

摘要：Purpose: Imbalances in protein homeostasis affect human brain development, with the ubiquitin-proteasome system (UPS) and autophagy playing crucial roles in neurodevelopmental disorders (NDD). This st...

关键词： Loss-of-function variants | N-terminal methionine excision | Neurodevelopmental disorders | Ubiquitin-proteasome system | USP14 | DEUBIQUITINATING ENZYME | INTELLECTUAL DISABILITY | PROTEINS | UBIQUITINATION | ASSOCIATION...

摘要：Serine hydroxymethyltransferase 2 (SHMT2) converts serine into glycine in the mitochondrial matrix, transferring a methyl group to tetrahydrofolate. SHMT2 plays an important role in the maintenance of...

关键词： SHMT2 | Glycine | Lipid metabolism | mTOR | PPAR gamma | FATTY LIVER-DISEASE | PPAR-GAMMA | HEPATIC LIPOGENESIS | GENE-EXPRESSION | HEPATOCELLULAR-CARCINOMA...

摘要：The microstructure of extruded Cu-free Al-Zn-Mg alloy is studied. Hot torsion tests are performed on a Cu-free Al-Zn-Mg alloy to investigate the effect of large strain deformation on the dislocation b...

关键词： Al-Zn-Mg Alloy | Hot Torsion Test | X-ray Line Profile

摘要：High-fat diet (HFD)-induced obesity is implicated in diabetic nephropathy (DN). EX-527, a selective Sirtuin 1 (SIRT1) inhibitor, has multiple biological functions; howeve...

关键词： High-fat diet | Diabetic nephropathy | EX-527 | Inflammation | Oxidative stress | SIRT | GROWTH-FACTOR RECEPTOR | INTERSTITIAL FIBROBLAST ACTIVATION | INDUCED OXIDATIVE STRESS | INHIBITS RENAL FIBROSIS...

摘要：Objective: Supplementation with serine attenuates alcoholic fatty liver by regulating homocysteine metabolism and lipogenesis. However, little is known about scrine metabolism in fatty liver disease (...

关键词： 3-Phosphoglycerate dehydrogenase (PHGDH) | Serine | High-fat diet | Non-alcoholic fatty liver disease (NAFID) | NRF2 | SIRT1

摘要：Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, and the function is linked to cellular metabolism including mitochondrial biogenesis. Hepa...

关键词： Insulin resistance | l-Serine | Mitochondrial biogenesis | Nicotinamide adenine dinucleotide (NAD(+)) | Silent information regulator 1 (SIRT1)

摘要：Acetaminophen (APAP)-induced liver injury (AILI) is initiated by the generation of a reactive metabolite and ultimately leads to hepatocyte necrosis. Necrotic cells secrete damage-associated molecular...

关键词： Acetaminophen | Fetuin-A | Hepatokine | Chemokine | Hepatotoxicity

4008-161-200 800-990-8900

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摘要：
High-fat diet (HFD)-induced obesity is implicated in diabetic nephropathy (DN). EX-527, a selective Sirtuin 1 (SIRT1) inhibitor, has multiple biological functions; howeve...