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1. Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis NSTL国家科技图书文献中心

Choi, You-Jin |  Nam, Yoon Ah... -  《Autophagy》 - 2025,21(4) - 827~839 - 共13页

摘要:SORT1 (sortilin 1), a member of the the Vps10 (vacuolar protein sorting 10) family, is involved in hepatic lipid metabolism by regulating very low-density lipoprotein (VLDL) secretion and facilitating...
关键词: Carboxylesterase 1 |  chaperone-mediated autophagy |  nonalcoholic fatty liver |  sortilin 1 |  triglyceride hydorolysis

2. Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner NSTL国家科技图书文献中心

Lim, Jin Ju |  Noh, Sujin... -  《Autophagy》 - 2024,20(12) - 2752~2768 - 共17页

摘要:Aging is often accompanied by a decline in proteostasis, manifested as an increased propensity for misfolded protein aggregates, which are prevented by protein quality control systems, such as the ubi...
关键词: Autophagy |  foxo |  IU1 |  proteostasis |  ubiquitin-proteasome system |  ubiquitin-specific peptidase 14

3. Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense NSTL国家科技图书文献中心

Choi, Eun-Ji |  Oh, Hyun-Taek... -  《Autophagy》 - 2024,20(11) - 2490~2510 - 共21页

摘要:Co-occurring mutations in KEAP1 in STK11/LKB1-mutant NSCLC activate NFE2L2/NRF2 to compensate for the loss of STK11-AMPK activity during metabolic adaptation. Characterizing the regulatory crosstalk b...
关键词: AXIN |  KEAP1 |  lysosomal stress |  metabolic stress |  oxidative stress |  STK11/LKB1

4. Biallelic USP14 variants cause a syndromic neurodevelopmental disorder NSTL国家科技图书文献中心

Ebstein, Frederic |  Latypova, Xenia... -  《Genetics in medicine》 - 2024,26(6) - 101120~101120 - 共6页

摘要:Purpose: Imbalances in protein homeostasis affect human brain development, with the ubiquitin-proteasome system (UPS) and autophagy playing crucial roles in neurodevelopmental disorders (NDD). This st...
关键词: Loss-of-function variants |  N-terminal methionine excision |  Neurodevelopmental disorders |  Ubiquitin-proteasome system |  USP14 |  DEUBIQUITINATING ENZYME |  INTELLECTUAL DISABILITY |  PROTEINS |  UBIQUITINATION |  ASSOCIATION...

5. The role of SHMT2 in modulating lipid metabolism in hepatocytes via glycine-mediated mTOR activation SCIE Web of Science核心 NSTL国家科技图书文献中心

Choi, You-Jin |  Lee, Geunhye... -  《Amino acids》 - 2022,54(5) - 823~834 - 共12页 - 被引量:5

摘要:Serine hydroxymethyltransferase 2 (SHMT2) converts serine into glycine in the mitochondrial matrix, transferring a methyl group to tetrahydrofolate. SHMT2 plays an important role in the maintenance of...
关键词: SHMT2 |  Glycine |  Lipid metabolism |  mTOR |  PPAR gamma |  FATTY LIVER-DISEASE |  PPAR-GAMMA |  HEPATIC LIPOGENESIS |  GENE-EXPRESSION |  HEPATOCELLULAR-CARCINOMA...

6. Dislocation Structure in Hot Deformed Al-Zn-Mg Alloy by X-ray Line Profile Analysis NSTL国家科技图书文献中心

Lee, Gyeong-Seo |  Kim, Sang-Wook... -  《Journal of nanoscience and nanotechnology》 - 2020,20(1) - 177~182 - 共6页 - 被引量:1

摘要:The microstructure of extruded Cu-free Al-Zn-Mg alloy is studied. Hot torsion tests are performed on a Cu-free Al-Zn-Mg alloy to investigate the effect of large strain deformation on the dislocation b...
关键词: Al-Zn-Mg Alloy |  Hot Torsion Test |  X-ray Line Profile

7. Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Sim, Woo-Cheol |  Lee, Wonseok... -  《Metabolism: Clinical and Experimental》 - 2020,102 - 共10页 - 被引量:17

摘要:Objective: Supplementation with serine attenuates alcoholic fatty liver by regulating homocysteine metabolism and lipogenesis. However, little is known about scrine metabolism in fatty liver disease (...
关键词: 3-Phosphoglycerate dehydrogenase (PHGDH) |  Serine |  High-fat diet |  Non-alcoholic fatty liver disease (NAFID) |  NRF2 |  SIRT1

8. Protective effect of EX-527 against high-fat diet-induced diabetic nephropathy in Zucker rats NSTL国家科技图书文献中心

Kundu, Amit |  Richa, Sachan... -  《Toxicology and Applied Pharmacology》 - 2020,390 - 114899~114899 - 共5页 - 被引量:16

摘要:

High-fat diet (HFD)-induced obesity is implicated in diabetic nephropathy (DN). EX-527, a selective Sirtuin 1 (SIRT1) inhibitor, has multiple biological functions; howeve...

关键词: High-fat diet |  Diabetic nephropathy |  EX-527 |  Inflammation |  Oxidative stress |  SIRT |  GROWTH-FACTOR RECEPTOR |  INTERSTITIAL FIBROBLAST ACTIVATION |  INDUCED OXIDATIVE STRESS |  INHIBITS RENAL FIBROSIS...

9. Activation of SIRT1 by l-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes (l-serine activates SIRT1 in C2C12 myotubes) SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Sim, Woo-Cheol |  Kim, Dong Gwang... -  《Cell Biology and Toxicology》 - 2019,35(5) - 457~470 - 共14页 - 被引量:16

摘要:Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, and the function is linked to cellular metabolism including mitochondrial biogenesis. Hepa...
关键词: Insulin resistance |  l-Serine |  Mitochondrial biogenesis |  Nicotinamide adenine dinucleotide (NAD(+)) |  Silent information regulator 1 (SIRT1)

10. Hepatic upregulation of fetuin-A mediates acetaminophen-induced liver injury through activation of TLR4 in mice SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Lee, Kang-Yo |  Lee, Wonseok... -  《Biochemical Pharmacology》 - 2019,166 - 46~55 - 共10页 - 被引量:12

摘要:Acetaminophen (APAP)-induced liver injury (AILI) is initiated by the generation of a reactive metabolite and ultimately leads to hepatocyte necrosis. Necrotic cells secrete damage-associated molecular...
关键词: Acetaminophen |  Fetuin-A |  Hepatokine |  Chemokine |  Hepatotoxicity
检索条件作者:Lee, Byung-Hoon

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