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- (1)2023

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1. Quantitative analytics for protein refolding states NSTL国家科技图书文献中心

Chika Linda Igwe | Jan Niklas Pauk ... - 《Process biochemistry》 - 2024,136(Jan.) - 191～201 - 共11页 - 被引量：2

摘要：Development and optimization of inclusion body (IB) refolding processes is often based on empirical strategies. Thus, generation of in-depth process understanding is crucial to shift towards more know...

关键词： Inclusion body | Refolding dynamics | Protein state | Process analytical technology | Signal-to-noise-ratio

2. Workflow for adaptation, analysis and application of mechanistic models for experimental planning of protein refolding processes NSTL国家科技图书文献中心

Jan Niklas Pauk | Chika Linda Igwe ... - 《33rd European Symposium on Computer Aided Process Engineering: ESCAPE-33, volume 1》 - European Symposium on Computer Aided Process Engineering - 2023, - 481～486 - 共6页

摘要：Mechanistic models are an important tool as they allow storage of process knowledge and enable model-based techniques to plan, monitor, and control biological processes. Fundamental to these operation...

关键词： Mechanistic Model | Identifiability | Fisher Information | Protein Refolding | MBDOE

3. Comprehensive evaluation of recombinant lactate dehydrogenase production from inclusion bodies OA开放获取

Chika Linda Igwe | Jan Niklas Pauk ... - 《Journal of Biotechnology.X》 - 2024,379 - 65～77 - 共13页

摘要：A broad application spectrum ranging from clinical diagnostics to biosensors in a variety of sectors, makes the enzyme Lactate dehydrogenase (LDH) highly interesting for recombinant protein production...

关键词： Recombinant production | Lactate dehydrogenase | Inclusion body | Refolding dynamics | Processing chain | Enzyme characterization

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作者：Jan Niklas Pauk

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