NSTL国家科技图书文献中心

1. Detecting Misfolded α-Synuclein in Blood Years before the Diagnosis of Parkinson's Disease NSTL国家科技图书文献中心

Kluge, Annika | Schaeffer, Eva ... - 《Movement disorders》 - 2024,39(8) - 1289～1299 - 共11页 - 被引量：15

摘要：BackgroundIdentifying individuals with Parkinson's disease (PD) already in the prodromal phase of the disease has become a priority objective for opening a window for early disease-modifying therapies...

关键词： Parkinson's disease | alpha-synuclein | seed amplification assay | neuron-derived extracellular vesicles | biomarker | SLEEP BEHAVIOR DISORDER | SCREENING QUESTIONNAIRE | PLASMA | CSF | VALIDATION...

2. How specific are non-motor symptoms in the prodrome of Parkinson's disease compared to other movement disorders? SCIE Web of Science核心 NSTL国家科技图书文献中心

Moscovich, Mariana | Heinzel, Sebastian ... - 《Parkinsonism & related disorders》 - 2020,81 - 213～218 - 共6页 - 被引量：8

摘要：The clinical diagnosis of Parkinson's disease (PD) based on motor signs is often preceded by several non-motor symptoms that can indicate early prodromal neurodegenerative processes. Such prodromal sy...

关键词： Marker | Neurodegeneration | Non-motor | Presymptomatic | Prodromal | SLEEP BEHAVIOR DISORDER | PROGRESSIVE SUPRANUCLEAR PALSY | HUNTINGTONS-DISEASE | NEURODEGENERATIVE DISEASE | RESEARCH CRITERIA...

3. The effect of age and gender on anti-saccade performance: Results from a large cohort of healthy aging individuals SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Mack, David J. | Heinzel, Sebastian ... - 《The European Journal of Neuroscience》 - 2020,52(9/10) - 4165～4184 - 共20页 - 被引量：6

摘要：By 2050, the global population of people aged 65 years or older will triple. While this is accompanied with an increasing burden of age-associated diseases, it also emphasizes the need to understand t...

关键词： eye movements | eye tracking | gender differences | healthy aging | humans | main sequence | trial history

4. Tipping points of gastric pH regulation and energetics in the sea urchin larva exposed to CO2-induced seawater acidification SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Lee, Hae-Gyeong | Stumpp, Meike ... - 《Comparative biochemistry and physiology, Part A. Molecular and integrative physiology》 - 2019,234 - 87～97 - 共11页 - 被引量：25

摘要：Sea urchin larvae reduce developmental rates accompanied by changes in their energy budget when exposed to acidified conditions. The necessity to maintain highly alkaline conditions in their digestive...

关键词： Ocean acidification | Echinoderm larvae | Acid-base regulation | Midgut pH | Physiology | Development | Strongylocentrotus purpuratus

5. Structural Ultrasound of the Medial Temporal Lobe in Alzheimer's Disease SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Yilmaz, Rezzak | Pilotto, Andrea ... - 《Ultraschall in der Medizin: Organ der Deutschen Gesellschaft fu?r Ultraschall in der Medizin, [der] O?sterreichischen Gesellschaft fu?r Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft fu?r Ultraschall in Medizin und Biologie》 - 2017,38(3) - 294～300 - 共7页 - 被引量：7

摘要：Purpose One of the anatomical hallmarks of Alzheimer's disease (AD) is the atrophy of the medial temporal lobe (MTL), yet cost-effective and broadly available methodological alternatives to the curren...

关键词： transcranial sonography | medial temporal lobe | Alzheimer's disease

6. Application of the Movement Disorder Society Prodromal Parkinson's Disease Research Criteria in 2 Independent Prospective Cohorts SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Pilotto, Andrea | Heinzel, Sebastian ... - 《Movement disorders》 - 2017,32(7) - 1025～1034 - 共10页 - 被引量：64

摘要：Background: The research criteria for prodromal PD of the MDS propose a new approach for the assessment of the individual probability of prodromal PD. These criteria require a testing of their reliabi...

关键词： Prodromal markers | research criteria | Parkinson's disease | early detection | premotor

7. Motor dual-tasking deficits predict falls in Parkinson's disease: A prospective study SCIE Web of Science核心 NSTL国家科技图书文献中心

Heinzel, Sebastian | Maechtel, Mirjam ... - 《Parkinsonism & related disorders》 - 2016,26 - 73～77 - 共5页 - 被引量：66

摘要：Introduction: Falls severely affect lives of Parkinson's disease (PD) patients. Cognitive impairment including dual-tasking deficits contribute to fall risk in PD. However, types of dual-tasking defic...

关键词： Parkinson's disease | Fall prediction | Dual-task | Motor coordination | Cognition

8. State-dependent altered connectivity in late-life depression: a functional near-infrared spectroscopy study SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Rosenbaum, David | Hagen, Katja ... - 《Neurobiology of Aging: Experimental and Clinical Research》 - 2016,39 - 57～68 - 共12页 - 被引量：32

摘要：There is a large body of evidence showing a substantial relationship between depression and deficits in cognitive functioning. Especially in late-life depression, cognitive impairments are associated ...

关键词： Late-life depression | Functional connectivity | Network analysis | Near-infrared spectroscopy | Cognitive control network | Executive functioning

9. Association of Plasma A beta(40) Peptides, But Not A beta(42), with Coronary Artery Disease and Diabetes Mellitus NSTL国家科技图书文献中心

Roeben, Benjamin | Maetzler, Walter ... - 《Journal of Alzheimer's disease: JAD》 - 2016,52(1) - 161～169 - 共9页 - 被引量：12

摘要：Background/Objective: Plasma levels of amyloid-beta (A beta) 1-40 peptide have been proposed to be associated with cardiovascular mortality in patients with coronary artery disease (CAD). Therefore, w...

关键词： Alzheimer's disease | amyloid-beta | APOE genotype | coronary artery disease | diabetes mellitus | vascular

10. Methods in Neuroepidemiology Characterization of European Longitudinal Cohort Studies in Parkinson's Disease - Report of the JPND Working Group BioLoC-PD SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Lerche, Stefanie | Liepelt-Scarfone, In...... - 《Neuroepidemiology》 - 2015,45(4) - 282～297 - 共16页 - 被引量：16

摘要：Background: Enormous effort is being put into the identification and characterization of symptoms that may be used as predictive and progression markers in Parkinson's disease (PD). An impressive numb...