NSTL国家科技图书文献中心

1. Volume and Permeability of White Matter Hyperintensity on Cognition: A DCE Imaging Study of an Older Cohort With and Without Cognitive Impairment NSTL国家科技图书文献中心

Lim, Changmok | Lee, Hunwoo ... - 《Journal of magnetic resonance imaging》 - 2025,61(5) - 2260～2270 - 共11页

摘要：Background: The impact of blood-brain barrier (BBB) leakage on white matter hyperintensity (WMH) subtypes (location) and its association with clinical factors and cognition remains unclear. Purpose: T...

关键词： blood-brain barrier | elderly | permeability | prospective | volume | white matter hyperintensity | blood–brain barrier

2. Roles of metabotropic signaling of nicotine receptors in the development and maintenance of nicotine reward through regulation of dopamine D 3 receptor expression NSTL国家科技图书文献中心

Kundu, Dooti | Acharya, Srijan ... - 《Journal of neurochemistry.》 - 2025,169(1) - e16271～e16271 - 共19页

摘要：The alpha 4 beta 2 nicotinic acetylcholine receptor (nAChR), an ionophore, has been suggested to signal through metabotropic pathways and interact with other receptor families, such as dopamine recept...

关键词： conditioned place preference | dopamine D-3 receptor | ligand | NF-kappa B | nicotine reward | alpha 4 beta 2 nicotinic receptors | dopamine D3 receptor | NF‐κB | α4β2 nicotinic receptors

3. Effect of genetic and vascular risk factors on rates of cognitive decline in early-onset and late-onset Alzheimer's disease NSTL国家科技图书文献中心

Li, Yunyi | Sanjay, Apoorva Bhar...... - 《Journal of Alzheimer's disease》 - 2025,103(3) - 920～930 - 共11页

摘要：Background: Although previous studies have shown that cognitive decline in Alzheimer's disease (AD) is associated with various risk factors, they primarily focused on late-onset AD (LOAD). Objective: ...

关键词： Alzheimer's disease | Apolipoprotein E4 (APOE epsilon 4) | cognitive decline

4. Impact and Interrelationships of Striatal Proteins, EPHB2, OPRM1, and PER2 on Mild Cognitive Impairment NSTL国家科技图书文献中心

Campomayor, Nicole B... | Kim, Hee Jin ... - 《Molecular Neurobiology》 - 2025,62(2) - 1478～1492 - 共15页

摘要：With the global increase in life expectancy, there has been a rise in the incidence of cognitive impairments attributed to diverse etiologies. Notably, approximately 50% of individuals diagnosed with ...

关键词： Mild cognitive impairment | Per2 | EPHB2 | OPRM1 | Amyloid beta

5. Evaluation of microstructure and toughness of SAW steel weld metals with optimum Al/O ratio NSTL国家科技图书文献中心

Seo, Kangmyung | Kang, Yongjoon ... - 《Welding in the World: Journal of the International Institute of Welding: Journal of the International Institute of Welding》 - 2024,68(8) - 2013～2021 - 共9页

摘要：A study was made to understand the possible effect of the Al/O ratio on the Charpy V-notch impact properties of submerged arc weld metals within the optimum range of Al/O ratio previously reported to ...

关键词： Weld microstructure | Acicular ferrite | Weld toughness | Grain size | Manganese-depleted zone (MDZ) | ACICULAR FERRITE | MECHANICAL-PROPERTIES | INCLUSIONS | TI | NUCLEATION...

6. Adult ADHD: it is old and new at the same time - what is it? NSTL国家科技图书文献中心

Custodio, Raly James... | Hengstler, Jan G.... - 《Reviews in the neurosciences》 - 2024,35(2) - 225～241 - 共17页

摘要：Even though the number of studies aiming to improve comprehension of ADHD pathology has increased in recent years, there still is an urgent need for more effective studies, particularly in understandi...

关键词： attention-deficit/hyperactivity disorder (ADHD) | adult ADHD | preclinical ADHD studies | clinical ADHD studies | ADHD presentations | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | DEFICIT HYPERACTIVITY DISORDER | DOPAMINE-D4 RECEPTOR | EXECUTIVE FUNCTION | QUANTITATIVE EEG...

7. Prediction of Amyloid Positivity in Patients with Subcortical Vascular Cognitive Impairment NSTL国家科技图书文献中心

Moon, Hasom | Ham, Hongki ... - 《Journal of Alzheimer's disease: JAD》 - 2024,99(3) - 1117～1127 - 共11页

摘要：Background: Amyloid-beta (A beta) commonly coexists and impacts prognosis in subcortical vascular cognitive impairment (SVCI).Objective: This study aimed to examine the differences in clinical and neu...

关键词： Alzheimer's disease | amyloid-beta | dementia | mild cognitive impairment | subcortical vascular cognitive impairment | SMALL VESSEL DISEASE | ALZHEIMERS-DISEASE | BETA BURDEN | DEMENTIA | MRI...

8. Extracts of Prunella vulgaris Enhanced Pentobarbital-Induced Sleeping Behavior in Mice Potentially via Adenosine A 2A Receptor Activity NSTL国家科技图书文献中心

Sayson, Leandro Val | Campomayor, Nicole B...... - 《Planta medica: Natural products and medicinal plant research》 - 2024,90(11) - 864～875 - 共12页

摘要：The increasing prevalence of sleep dysregulation cases has prompted the search for effective and safe sleep-enhancing agents. Numerous medications used in the treatment of sleep disorders function by ...

关键词： Prunella vulgaris | Lamiaceae | sleep | adenosine A(2A) receptor | EEG | sleep-wake cycle | caffeine | REM | DISORDERS | INJECTION...

9. Fabrication and evaluation of stable amorphous polymer-drug composite particles via a nozzle-free ultrasonic nebulizer NSTL国家科技图书文献中心

Lee, Jieun | Han, Chang Hun ... - 《International Journal of Pharmaceutics》 - 2024,657 - 124177～124177 - 共6页

摘要：We present a promising method for producing amorphous drug particles using a nozzle-free ultrasonic nebulizer with polymers, specifically polyvinylpyrrolidone (PVP), poly(acrylic acid) (PAA), and Eudr...

关键词： Ultrasonic nebulizer | Amorphous solid dispersion | Composite particle | Crystalline drug | Polymer | Bioavailability | HOT-MELT EXTRUSION | SOLID DISPERSION | DISSOLUTION | STABILITY...

10. Clinical and Pathological Validation of CT-Based Regional Harmonization Methods of Amyloid PET NSTL国家科技图书文献中心

Kim, Soo-Jong | Jang, Hyemin ... - 《Clinical nuclear medicine》 - 2024,49(1) - 1～8 - 共8页

摘要：Purpose: The CT-based regional direct comparison Centiloid (dcCL) method was developed to harmonize and quantify regional beta-amyloid (A beta) burden. In the present study, we aimed to investigate co...

摘要：Background: The impact of blood-brain barrier (BBB) leakage on white matter hyperintensity (WMH) subtypes (location) and its association with clinical factors and cognition remains unclear. Purpose: T...

关键词： blood-brain barrier | elderly | permeability | prospective | volume | white matter hyperintensity | blood–brain barrier

摘要：The alpha 4 beta 2 nicotinic acetylcholine receptor (nAChR), an ionophore, has been suggested to signal through metabotropic pathways and interact with other receptor families, such as dopamine recept...

关键词： conditioned place preference | dopamine D-3 receptor | ligand | NF-kappa B | nicotine reward | alpha 4 beta 2 nicotinic receptors | dopamine D3 receptor | NF‐κB | α4β2 nicotinic receptors

摘要：Background: Although previous studies have shown that cognitive decline in Alzheimer's disease (AD) is associated with various risk factors, they primarily focused on late-onset AD (LOAD). Objective: ...

关键词： Alzheimer's disease | Apolipoprotein E4 (APOE epsilon 4) | cognitive decline

摘要：With the global increase in life expectancy, there has been a rise in the incidence of cognitive impairments attributed to diverse etiologies. Notably, approximately 50% of individuals diagnosed with ...

关键词： Mild cognitive impairment | Per2 | EPHB2 | OPRM1 | Amyloid beta

摘要：A study was made to understand the possible effect of the Al/O ratio on the Charpy V-notch impact properties of submerged arc weld metals within the optimum range of Al/O ratio previously reported to ...

关键词： Weld microstructure | Acicular ferrite | Weld toughness | Grain size | Manganese-depleted zone (MDZ) | ACICULAR FERRITE | MECHANICAL-PROPERTIES | INCLUSIONS | TI | NUCLEATION...

摘要：Even though the number of studies aiming to improve comprehension of ADHD pathology has increased in recent years, there still is an urgent need for more effective studies, particularly in understandi...

关键词： attention-deficit/hyperactivity disorder (ADHD) | adult ADHD | preclinical ADHD studies | clinical ADHD studies | ADHD presentations | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | DEFICIT HYPERACTIVITY DISORDER | DOPAMINE-D4 RECEPTOR | EXECUTIVE FUNCTION | QUANTITATIVE EEG...

摘要：Background: Amyloid-beta (A beta) commonly coexists and impacts prognosis in subcortical vascular cognitive impairment (SVCI).Objective: This study aimed to examine the differences in clinical and neu...

关键词： Alzheimer's disease | amyloid-beta | dementia | mild cognitive impairment | subcortical vascular cognitive impairment | SMALL VESSEL DISEASE | ALZHEIMERS-DISEASE | BETA BURDEN | DEMENTIA | MRI...

摘要：The increasing prevalence of sleep dysregulation cases has prompted the search for effective and safe sleep-enhancing agents. Numerous medications used in the treatment of sleep disorders function by ...

关键词： Prunella vulgaris | Lamiaceae | sleep | adenosine A(2A) receptor | EEG | sleep-wake cycle | caffeine | REM | DISORDERS | INJECTION...

摘要：We present a promising method for producing amorphous drug particles using a nozzle-free ultrasonic nebulizer with polymers, specifically polyvinylpyrrolidone (PVP), poly(acrylic acid) (PAA), and Eudr...

关键词： Ultrasonic nebulizer | Amorphous solid dispersion | Composite particle | Crystalline drug | Polymer | Bioavailability | HOT-MELT EXTRUSION | SOLID DISPERSION | DISSOLUTION | STABILITY...

摘要：Purpose: The CT-based regional direct comparison Centiloid (dcCL) method was developed to harmonize and quantify regional beta-amyloid (A beta) burden. In the present study, we aimed to investigate co...

关键词： amyloid PET | CT | Centiloid | neuropathological assessments | clinical utility | POSITRON-EMISSION-TOMOGRAPHY | BETA PLAQUES

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