Karst, Henk |  Llobet, Arianna Rier...... -  《Behavioural Brain Research》 - 2025,476 - 115233～115233 - 共10页 - 被引量：1

摘要：The prefrontal cortex (PFC) plays an important role in social behavior and is sensitive to stressful circumstances. Challenging life conditions might change PFC function and put individuals at risk fo...

关键词： Enriched environment |  Electrophysiology |  mIPSC |  mEPSC |  Corticosterone |  PFC layer 2/3

Karst, Henk |  den Boon, Femke S.... -  《Molecular and Cellular Endocrinology》 - 2022,541 - 111501～111501 - 共5页 - 被引量：10

摘要：Corticosteroid receptors in the mammalian brain mediate genomic as well as non-genomic actions. Although receptors mediating genomic actions were already cloned 35 years ago, it remains unclear whethe...

关键词： Mineralocorticoid receptor |  Non-genomic |  Membrane localization |  Internalization |  Beta-arrestin |  LONG-TERM POTENTIATION |  ENDOCANNABINOID RELEASE |  PLASMA-MEMBRANE |  GLUCOCORTICOID-RECEPTORS |  BETA-ARRESTINS...

Huffels, Christiaan ... |  van Dijk, Roland E.... -  《Journal of Alzheimer's disease: JAD》 - 2022,89(1) - 283～297 - 共15页

摘要：Background: Aging is characterized by systemic alterations and forms an important risk factor for Alzheimer's disease (AD). Recently, it has been indicated that blood-borne factors present in the syst...

关键词： Aging |  Alzheimer's disease |  calcium |  calcium channels |  hippocampus |  neuronal plasticity |  plasma |  LONG-TERM POTENTIATION |  BASAL FOREBRAIN NEURONS |  CALCIUM CURRENTS...

Karst, Henk |  Sarabdjitsingh, R. A...... -  《Neuropharmacology》 - 2020,180 - 共12页 - 被引量：7

摘要：In this study we tested the hypothesis i) that age-dependent shifts in the excitation-inhibition balance of pre-frontal neurons are accelerated by early life stress, a risk factor for the etiology of ...

关键词： Early life stress |  Glutamate |  GABA |  Prefrontal cortex |  Electrophysiology |  Gene expression |  Morphology |  Mineralocorticoid receptor

Karst, Henk |  Joels, Marian -  《Neuropharmacology》 - 2016,110(Pt.A) - 175～180 - 共6页 - 被引量：27

摘要：Shortly after stress, basolateral amygdala neurons are exposed to sequential yet partly overlapping waves of hormones. We examined how these hormonal waves can change activity of basolateral amygdala ...

关键词： Corticosterone |  Norad renal ine |  Metaplasticity |  mEPSC |  PTSD |  Consolidation

den Boon, Femke Susa... |  de Vries, Tessa... -  《Endocrinology》 - 2019,160(4) - 791～802 - 共12页 - 被引量：12

摘要：The hypothalamic-pituitary-adrenal axis involves timed signaling between the hypothalamus, pituitary, and adrenal glands and back to the brain, causing an inherently oscillating system. Corticosteroid...

Harschnitz, Oliver |  van den Berg, Leonar...... -  《Annals of neurology》 - 2016,80(1) - 71～88 - 共18页 - 被引量：38

摘要：Objective: We investigated the pathogenicity of immunoglobulin M (IgM) anti-GM1 antibodies in serum from patients with multifocal motor neuropathy (MMN) using human induced pluripotent stem cell (iPSC...

Joels, Marian |  Fernandez, Guillen... -  《Psychoneuroendocrinology: An International Journal》 - 2015,61 - 13～13 - 共1页 - 被引量：1

Joels, Marian |  Sarabdjitsingh, R. A...... -  《Pharmacological reviews》 - 2012,64(4) - 901～938 - 共38页 - 被引量：249

摘要：Brain cells are continuously exposed to corticosteroid hormones, although the levels vary (e. g., after stress). Corticosteroids alter neural activity via two receptor types, mineralocorticoid (MR) an...

Varderidou-Minasian,... |  Verheijen, Bert M.... -  《acs omega》 - 2021,6(51) - 35375～35388 - 共14页 - 被引量：7

摘要：Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder characterized by loss of motor neurons (MN) in the spinal cord leading to progressive muscle atrophy and weakness. SM...

关键词： DETERMINING GENE-PRODUCT |  PLURIPOTENT STEM-CELLS |  MESSENGER-RNA |  SMN PROTEIN |  SINGLE NUCLEOTIDE |  MOUSE MODELS |  SURVIVAL |  DEFICIENCY |  COMPLEX |  IDENTIFICATION