Le Collen L. |  Froguel P.... -  《Trends in Endocrinology and Metabolism》 - 2025,36(2) - 109～117 - 共9页

摘要：© 2024 Elsevier LtdThe demarcation between monogenic and polygenic type 2 diabetes (T2D) is less distinct than previously believed. Notably, recent research has highlighted a new entity, that we sugge...

关键词： monogenic |  oligogenic |  polygenic |  rare variant |  type 2 diabetes

Hager J. |  Francke S.... -  《Nature Genetics》 - 1998,20(3) - 304～308 - 共5页

摘要：Obesity, a common multifactorial disorder, is a major risk factor for type 2 diabetes, hypertension and coronary heart disease(1) (CHD). According to the definition of the World Health Organization (W...

关键词： Leptin receptor gene |  Human ob gene |  Quantitative trait |  Markers flanking |  Extreme obesity |  Pima-indians |  Linkage |  Mutation |  Absence |  Weight

Folon L. |  Baron M.... -  《The lancet. Diabetes & endocrinology.》 - 2023,11(3) - 182～190 - 共9页 - 被引量：10

摘要：? 2023 Elsevier LtdBackground: Rare biallelic pathogenic mutations in PCSK1 (encoding proprotein convertase subtilisin/kexin type 1 [PC1/3]) cause early-onset obesity associated with various endocrino...

Karamitri A. |  Plouffe B.... -  《Science Signaling》 - 2018,11(545) - 共18页 - 被引量：28

摘要：Copyright © 2018 The Authors, some rights reserved.Melatonin is produced during the night and regulates sleep and circadian rhythms. Loss-of-function variants in MTNR1B, which encodes the melatonin re...

Vaisse C. |  Guy-Grand B.... -  《Nature Genetics》 - 1998,20(2) - 113～114 - 共2页

关键词： Melanocortin receptors |  Leptin

Velho G. |  Froguel P. -  《Medecine Therapeutique》 - 1997,3(SPEC. ISS. 2) - 12～19

Clement K. |  Basdevant A.... -  《Sang Thrombose Vaisseaux》 - 1997,9(8) - 487～496

Froguel P. |  Velho G. -  《La revue du praticien》 - 1996,46(15) - 1813～1817