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1. Characterization of monoclonal antibodies and antibody-drug conjugates using native mass spectrometry and electron activated dissociation-based middle-down workflows NSTL国家科技图书文献中心

Haichuan Liu |  Elliott Jones... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.3》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 495968～495968 - 共1页

摘要：This poster highlights the combined power of orthogonal native mass spectrometry (MS) and electron activated dissociation (EAD)-based middle-down workflows for rapid and comprehensive characterization...
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2. Sensitive and selective quantitation of bimatoprost in human plasma using accurate mass spectrometry NSTL国家科技图书文献中心

Sujata Rajan |  Sashank Pillai... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.3》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 495828～495828 - 共1页

摘要：1. Bimatoprost is a widely used medication for treating glaucoma by reducing intraocular pressure. When one drop of 0.03% bimatoprost was administered to both eyes daily for 2 weeks, blood concentrati...
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3. Redefining bioanalysis: assessment of a mass spectrometer robustness versus complex matrix NSTL国家科技图书文献中心

Elliott Jones |  Rahul Baghla... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.3》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 495829～495829 - 共1页

摘要：1. To ensure accurate and precise results, analytical labs need reliable and robust instruments and methods. Bioanalytical methods that can handle the inherent variability of analyzing diverse samples...
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4. Leverage orthogonal technologies: cIEF, icIEF-UV/MS and LC-MS to facilitate biotherapeutics development NSTL国家科技图书文献中心

Marcia Santos |  Rashmi Madda... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.3》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 495373～495373 - 共1页

摘要：This poster describes the utility of orthogonal technologies, such as capillary isoelectric focusing (cIEF), imaged cIEF (icIEF)-UV/MS, and LC-MS based peptide mapping and middle-down workflows in the...
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5. Characterization of Antibody Binding Epitopes Using Carbene Chemical Footprinting and Electron Activated Dissociation NSTL国家科技图书文献中心

Fan Zhang |  Haichuan Liu... -  《72nd ASMS Conference on Mass Spectrometry and Allied Topics,Vol.3》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2024, - 495978～495978 - 共1页

摘要：Rapid assessment of antibody epitopes is important for supporting therapeutic candidate lead selection. Although X-ray crystallography and cryo-EM provide atomic-level resolution of binding epitopes, ...
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6. Application of Electro-Activated Dissociation Fragmentation Technique to Identifying Glucuronidation and Oxidative Metabolism Sites of Vepdegestrant by Liquid Chromatography-High Resolution Mass Spectrometry NSTL国家科技图书文献中心

Yifei He |  Pengyi Hou... -  《Drug Metabolism and Disposition》 - 2024,52(7) - 634～643 - 共10页

摘要：Drug metabolite identification is an integrated part of drug metabolism and pharmacokinetics studies in drug discovery and development. Definitive identification of metabolic modification sides of tes...
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7. Identification and differentiation of positional isomers of O-linked glycopeptides of etanercept using an alternative electron-based MS/MS approach NSTL国家科技图书文献中心

Haichuan Liu |  Xuezhi Bi... -  《71st ASMS Conference on Mass Spectrometry and Allied Topics, Vol.3: Houston, TX, USA.June 4-8 2023》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2023, - 475510.1-475510.1～ - 共1页

摘要：This poster highlights the power of electron-activated dissociation (EAD) for the confident identification and unambiguous localization of O-linked glycosylation in etanercept. The unique ability of E...
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8. Development of a streamlined single-injection workflow for middle-down analysis of protein therapeutics using electron activated dissociation (EAD) NSTL国家科技图书文献中心

Haichuan Liu |  Elliott Jones... -  《71st ASMS Conference on Mass Spectrometry and Allied Topics, Vol.3: Houston, TX, USA.June 4-8 2023》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2023, - 475509.1-475509.1～ - 共1页

摘要：This poster highlights the power of a single-injection, EAD-based middle-down workflow to achieve consistently high sequence coverages (70%-85%) between injections or across different monoclonal antib...
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9. A sensitive method for the quantitation of formoterol in human plasma NSTL国家科技图书文献中心

Sashank Pillai |  Lakshmanan Deenadaya...... -  《71st ASMS Conference on Mass Spectrometry and Allied Topics, Vol.3: Houston, TX, USA.June 4-8 2023》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2023, - 475112.1-475112.1～ - 共1页

摘要：Formoterol is a highly effective, long-acting beta-2-selective adrenoceptor agonist used to treat pulmonary disorders. The lowest recommended daily dose of formoterol for children 12 years of age and ...
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10. Localization of labile tyrosine sulfation using an alternative electron-based MS/MS approach in positive and negative ion modes NSTL国家科技图书文献中心

Haichuan Liu |  Takashi Baba... -  《71st ASMS Conference on Mass Spectrometry and Allied Topics, Vol.3: Houston, TX, USA.June 4-8 2023》 -  ASMS Conference on Mass Spectrometry and Allied Topics - 2023, - 475512.1-475512.1～ - 共1页

摘要：This poster highlights the unique ability of electron-activated dissociation (EAD) to achieve accurate localization of labile tyrosine sulfation in both positive and negative ion modes. This was the f...
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