NSTL国家科技图书文献中心

1. Aberrant accumulation of phosphorylated BRCA1 in brainstem-type and cortical-type Lewy bodies in Lewy body disease NSTL国家科技图书文献中心

Nakamura, Masataka | Murakami, Aya ... - 《Journal of Neuropathology and Experimental Neurology》 - 2025,84(4) - 276～285 - 共10页

摘要：BRCA1 plays important roles in several biological events during the DNA damage response (DDR). We aimed to determine whether cytoplasmic accumulation of BRCA1 or its phosphorylated form, pBRCA1, is sp...

关键词： alpha-synuclein | BARD1 | BRCA1 | DNA damage response | Lewy body disease

2. Widespread distribution of α-synuclein oligomers in LRRK2 -related Parkinson's disease NSTL国家科技图书文献中心

Sekiya, Hiroaki | Franke, Lukas ... - 《Acta Neuropathologica》 - 2025,149(1) - Article: 42～Article: 42 - 共15页 - 被引量：2

摘要：Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson's disease (PD). While the clinical features of patients with LRRK2-PD resemble those of t...

关键词： Alpha-synuclein | Lewy bodies | LRRK2 | Oligomers | Parkinson disease | Pathogenesis

3. LATE-NC Stage 3: a diagnostic rubric to differentiate severe LATE-NC from FTLD-TDP NSTL国家科技图书文献中心

Shahidehpour, Ryan K... | Katsumata, Yuriko ... - 《Acta Neuropathologica》 - 2025,149(1) - Article: 38～Article: 38 - 共21页

摘要：A diagnostic rubric is required to distinguish between limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and frontotemporal lobar degeneration with TDP-43 inclusion...

关键词： LNT | ALS | ARTAG | FTLD-MND | rs1990622 | ScanScope

4. High resolution autoradiography of [ 18 F]MK-6240 and [ 18 F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity NSTL国家科技图书文献中心

Ghatamaneni, Sujala | Hruska, Courtney ... - 《Acta Neuropathologica》 - 2025,149(1) - Article: 26～Article: 26 - 共11页

摘要：Recent developments in tau positron emission tomography (PET) radiotracers have enhanced the visualization of tau aggregates in Alzheimer's disease (AD). The maturity level of neurofibrillary tangles ...

关键词： [F-18]MK-6240 | [F-18]Flortaucipir | Tau | Alzheimer's disease | Corticobasal degeneration | Progressive supranuclear palsy | Tauopathy | Atypical Alzheimer's disease | svPPA | Frontotemporal dementia...

5. Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens NSTL国家科技图书文献中心

Di Liberto, Giovanni | Egervari, Kristof ... - 《Acta Neuropathologica》 - 2025,149(1) - Article: 35～Article: 35 - 共19页

摘要：Autoimmune encephalitis (AE) is an inflammatory syndrome of the central nervous system (CNS) triggered by aberrant immune responses against neuronal intracellular (IC-AE) or surface (NS-AE) autoantige...

关键词： Phagocytes | Neuroinflammation | Neurodegeneration | Synapses | Resident memory T cells

6. Frequency of Comorbid Pathologies and Their Clinical Impact in Multiple System Atrophy NSTL国家科技图书文献中心

Sekiya, Hiroaki | Koga, Shunsuke ... - 《Movement disorders》 - 2024,39(2) - 380～390 - 共11页 - 被引量：3

摘要：Background: Mixed pathology is common at autopsy for a number of age-associated neurodegenerative disorders; however, the frequency of comorbid pathologies in multiple system atrophy (MSA) and their c...

关键词： multiple system atrophy | comorbid pathology | clinicopathological | correlation | ALPHA-SYNUCLEIN OLIGOMERS | DEMENTIA | DISEASE | IMPAIRMENT | DIAGNOSIS | SPECTRUM...

7. Senile plaque-associated transactive response DNA-binding protein 43 in Alzheimer's disease: A case report spanning 16 years of memory loss NSTL国家科技图书文献中心

Carlos, Arenn F. | Koga, Shunsuke ... - 《Neuropathology :》 - 2024,44(2) - 115～125 - 共11页 - 被引量：1

摘要：Transactive response DNA-binding protein 43 (TDP-43) pathological inclusions are found in frontotemporal lobar degeneration (FTLD-TDP) and Alzheimer's disease (AD-TDP). While clinically different, TDP...

关键词： AD-TDP | case report | FTLD-TDP | limbic-predominant AD | neuritic plaque-associated TDP-43 | NEUROPATHOLOGIC ASSESSMENT | HIPPOCAMPAL SCLEROSIS | APOLIPOPROTEIN-E | TDP-43 | DEPOSITION...

8. TDP-43 Is Associated with Subiculum and Cornu Ammonis 1 Hippocampal Subfield Atrophy in Primary Age-Related Tauopathy NSTL国家科技图书文献中心

Youssef, Hossam | Gatto, Rodolfo G.... - 《Journal of Alzheimer's disease: JAD》 - 2024,99(3) - 1023～1032 - 共10页

摘要：Background: TAR DNA binding protein 43 (TDP-43) has been shown to be associated with whole hippocampal atrophy in primary age-related tauopathy (PART). It is currently unknown which subregions of the ...

关键词： Alzheimer's disease | Cornu Ammonis 1 | LATE-NC | primary age-related tauopathy | TAR DNA binding Protein 43 | type-alpha | ALZHEIMERS-DISEASE | PATHOLOGY | BETA | MRI...

9. Case report: pre-symptomatic clinical and metabolic profile in posterior cortical atrophy and dementia with Lewy bodies NSTL国家科技图书文献中心

Shir, Dror | Corriveau-Lecavalier...... - 《Neurocase: case studies in neuropsychology, neuropsychiatry, and behavioural neurology》 - 2024,30(1/2) - 1～7 - 共7页

摘要：A research participant was monitored over nearly two decades at Mayo Clinic, undergoing annual neurologic assessments, neuropsychological tests, and multimodal imaging. Initially, he was cognitively n...

关键词： Posterior cortical atrophy | diffuse Lewy Body Disease | FDG-PET | Alzheimer's disease | ALZHEIMERS-DISEASE

10. A rapidly progressive multiple system atrophy-cerebellar variant model presenting marked glial reactions with inflammation and spreading of α-synuclein oligomers and phosphorylated α-synuclein aggregates NSTL国家科技图书文献中心

Yamaguchi, Hiroo | Nishimura, Yuji ... - 《Brain, Behavior, and Immunity》 - 2024,121 - 122～141 - 共20页

摘要：Multiple system atrophy (MSA) is a severe alpha-synucleinopathy facilitated by glial reactions; the cerebellar variant (MSA-C) preferentially involves olivopontocerebellar fibres with conspicuous demy...

关键词： Multiple system atrophy | alpha-synuclein | alpha-synuclein oligomer | Phosphorylated alpha-synuclein aggregate | Demyelination | Microglia | Transgenic mouse model | Tet-Off system