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1. In vitro and in vivo (cyto)toxicity assays using PVC and LDPE as model materials. SCIE Web of Science核心 NSTL国家科技图书文献中心

Van Tienhoven EA | Korbee D ... - 《Journal of biomedical materials research, Part A》 - 2006,78(1) - 175～182 - 共8页

摘要：The choice for a biomaterial is partly based on the outcome of (cyto)toxicity assays. The rationales behind the selection of certain parameters, such as cell lines, controls, and animals, were evaluat...

关键词： Biocompatible Materials | Biological Assay | Polyethylene | Polyvinyl Chloride | 生物相容性材料 | 生物学鉴定法 | 聚氯乙烯 | 假体和植入物

2. Tissue response to partially in vitro predegraded poly-L-lactide implants. SCIE Web of Science核心 NSTL国家科技图书文献中心

De Jong WH | Eelco Bergsma J ... - 《Biomaterials》 - 2005,26(14) - 1781～1791 - 共11页

摘要：The in vivo local reaction of as-polymerized poly-L-lactide composed of 96% L-lactide and 4% D-lactide (PLA96) was investigated by histology at 2, 13 and 26 weeks after subcutaneous implantation in ra...

关键词： poly-96L 4D-lactide | week | Macrophages | In Vitro | poly(L-lactide) | 巨噬细胞

3. Long-term exposure to silicone breast implants does not induce antipolymer antibodies. SCIE Web of Science核心 NSTL国家科技图书文献中心

De Jong WH | Kallewaard M ... - 《Biomaterials》 - 2004,25(6) - 1095～1103 - 共9页

摘要：The focus of our studies was to determine whether the antipolymer antibody assay (APA) as an objective laboratory assay could contribute to the diagnosis in women with a silicone breast implant (SBI) ...

关键词： APA | Human Females | assay | Complaint | NOS

4. The Benign Concentric Annular Macular Dystrophy Locus Maps to 6p12.3-q16. SCIE Web of Science核心 NSTL国家科技图书文献中心

Van Lith Verhoeven J... | Hoyng CB ... - 《Investigative ophthalmology & visual science》 - 2004,45(1) - 30～35 - 共6页

摘要：PURPOSE. To describe the clinical findings and to identify the genetic locus in a Dutch family with autosomal dominant benign concentric annular macular dystrophy (BCAMD). METHODS. All family members ...

关键词： Genes | Benign | Phenotype | Mutation | Analysis of substances | 基因 | 表型 | 突变

5. Effect of prolonged exposure to low antigen concentration for sensitization. SCIE Web of Science核心 NSTL国家科技图书文献中心

van Och FM | Vandebriel RJ ... - 《Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems》 - 2003,184(1) - 23～30 - 共8页

摘要：The local lymph node assay (LLNA) is an assay in mice to identify potential allergens. Compounds that do not induce a stimulation index (SI)>/=3 are not considered sensitizers. Of the chemicals that d...

关键词： Local Lymph Node Assay | Silicon | Dinitrochlorobenzene | Classification of information | 硅 | 二硝基氯苯

6. Impact of exposure duration by low molecular weight compounds on interferon-gamma and interleukin-4 mRNA expression and production in the draining lymph nodes of mice. SCIE Web of Science核心 NSTL国家科技图书文献中心

Vandebriel RJ | De Jong WH ... - 《Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems》 - 2003,188(1) - 1～13 - 共13页

摘要：The local lymph node assay (LLNA) is used to identify allergens by means of dermal exposure. For hazard identification, besides identification also the distinction between contact and respiratory alle...

关键词： Allergens | Dinitrochlorobenzene | Interferon Type II | Interleukin-4 | Local Lymph Node Assay | 变应原 | 二硝基氯苯 | 干扰素Ⅱ型 | 白细胞介素4 | 淋巴结...

7. Medical devices manufactured from latex: European regulatory initiatives. SCIE Web of Science核心 NSTL国家科技图书文献中心

De Jong WH | Geertsma RE ... - 《Methods: A Companion to Methods in Enzymology》 - 2002,27(1) - 93～98 - 共6页

摘要：In Europe the marketing of medical devices manufactured from latex is regulated by directives describing the essential (safety) requirements that products have to fulfill to obtain marketing approval....

关键词： Latex | device aspects | Hypersensitivity | EUROPEAN | Marketing | 胶乳 | 超敏反应

8. Cytokine production induced by low-molecular-weight chemicals as a function of the stimulation index in a modified local lymph node assay: an approach to discriminate contact sensitizers from respiratory sensitizers. SCIE Web of Science核心 NSTL国家科技图书文献中心

Van Och FM | Van Loveren H ... - 《Toxicology and Applied Pharmacology》 - 2002,184(1) - 46～0 - 共1页

摘要：In general, contact sensitizers have been shown to selectively induce Th1 immune responses, such as interferon-gamma (IFN-gamma) production, whereas Th2 responses, such as interleukin (IL)-4 productio...

关键词： Allergens | Production | Respiratory | Dinitrochlorobenzene | oxytocin | Asp(5)- | 变应原 | 二硝基氯苯

9. Determination of the sensitising activity of the rubber contact sensitisers TMTD, ZDMC, MBT and DEA in a modified local lymph node assay and the effect of sodium dodecyl sulfate pretreatment on local lymph node responses. SCIE Web of Science核心 NSTL国家科技图书文献中心

De Jong WH | Tentij M ... - 《Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems》 - 2002,176(1/2) - 123～134 - 共12页

摘要：A modified local lymph node assay (LLNA) was used to determine the sensitising activity of four chemicals used for the production of natural rubber latex products. Tetramethylthiuramdisulfide (TMTD), ...

关键词： lymph nodes | Thiram | Rubber | Local Lymph Node Assay | Silicon | 塞兰姆 | 橡胶 | 硅

10. Developmental toxicity but no immunotoxicity in the rat after prenatal exposure to diethylstilbestrol. SCIE Web of Science核心 NSTL国家科技图书文献中心

Piersma AH | Verhoef A ... - 《Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems》 - 2002,174(3) - 173～181 - 共9页

摘要：Studies with dioxins and PCB's have shown that the developing immune system may be especially vulnerable to xenobiotics during the perinatal period. However, current guidelines for reproductive toxici...

摘要：The choice for a biomaterial is partly based on the outcome of (cyto)toxicity assays. The rationales behind the selection of certain parameters, such as cell lines, controls, and animals, were evaluat...

关键词： Biocompatible Materials | Biological Assay | Polyethylene | Polyvinyl Chloride | 生物相容性材料 | 生物学鉴定法 | 聚氯乙烯 | 假体和植入物

摘要：The in vivo local reaction of as-polymerized poly-L-lactide composed of 96% L-lactide and 4% D-lactide (PLA96) was investigated by histology at 2, 13 and 26 weeks after subcutaneous implantation in ra...

关键词： poly-96L 4D-lactide | week | Macrophages | In Vitro | poly(L-lactide) | 巨噬细胞

摘要：The focus of our studies was to determine whether the antipolymer antibody assay (APA) as an objective laboratory assay could contribute to the diagnosis in women with a silicone breast implant (SBI) ...

关键词： APA | Human Females | assay | Complaint | NOS

摘要：PURPOSE. To describe the clinical findings and to identify the genetic locus in a Dutch family with autosomal dominant benign concentric annular macular dystrophy (BCAMD). METHODS. All family members ...

关键词： Genes | Benign | Phenotype | Mutation | Analysis of substances | 基因 | 表型 | 突变

摘要：The local lymph node assay (LLNA) is an assay in mice to identify potential allergens. Compounds that do not induce a stimulation index (SI)>/=3 are not considered sensitizers. Of the chemicals that d...

关键词： Local Lymph Node Assay | Silicon | Dinitrochlorobenzene | Classification of information | 硅 | 二硝基氯苯

摘要：The local lymph node assay (LLNA) is used to identify allergens by means of dermal exposure. For hazard identification, besides identification also the distinction between contact and respiratory alle...

关键词： Allergens | Dinitrochlorobenzene | Interferon Type II | Interleukin-4 | Local Lymph Node Assay | 变应原 | 二硝基氯苯 | 干扰素Ⅱ型 | 白细胞介素4 | 淋巴结...

摘要：In Europe the marketing of medical devices manufactured from latex is regulated by directives describing the essential (safety) requirements that products have to fulfill to obtain marketing approval....

关键词： Latex | device aspects | Hypersensitivity | EUROPEAN | Marketing | 胶乳 | 超敏反应

摘要：In general, contact sensitizers have been shown to selectively induce Th1 immune responses, such as interferon-gamma (IFN-gamma) production, whereas Th2 responses, such as interleukin (IL)-4 productio...

关键词： Allergens | Production | Respiratory | Dinitrochlorobenzene | oxytocin | Asp(5)- | 变应原 | 二硝基氯苯

摘要：A modified local lymph node assay (LLNA) was used to determine the sensitising activity of four chemicals used for the production of natural rubber latex products. Tetramethylthiuramdisulfide (TMTD), ...

关键词： lymph nodes | Thiram | Rubber | Local Lymph Node Assay | Silicon | 塞兰姆 | 橡胶 | 硅

摘要：Studies with dioxins and PCB's have shown that the developing immune system may be especially vulnerable to xenobiotics during the perinatal period. However, current guidelines for reproductive toxici...

关键词： Toxic effect | Diethylstilbestrol | prenatal | Protocols documentation | immunotoxicity | 己烯雌酚

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