NSTL国家科技图书文献中心

1. Fetal MR Imaging Anatomy of the Transverse Temporal Gyrus (Heschl Gyrus) NSTL国家科技图书文献中心

Piccirilli, Eleonora | Marchetti, Chiara ... - 《AJNR. American journal of neuroradiology》 - 2023,44(11) - 1325～1331 - 共7页

摘要：BACKGROUND AND PURPOSE: The human auditory system develops early in fetal life. This retrospective MR imaging study describes the in vivo prenatal anatomic development of the transverse temporal gyrus...

关键词： GA = gestational age | HG = Heschl gyrus | SI = sulcus intermedius | ssFSE = single-shot fast spin-echo | NORMAL GESTATIONAL LANDMARKS | PRIMARY AUDITORY-CORTEX

2. MRI-Based Radiomics Approach Predicts Tumor Recurrence in ER+/HER2-Early Breast Cancer Patients NSTL国家科技图书文献中心

Chiacchiaretta, Pier... | Mastrodicasa, Domeni...... - 《Journal of digital imaging: the official journal of the Society for Computer Applications in Radiology》 - 2023,36(3) - 1071～1080 - 共10页

摘要：Oncotype Dx Recurrence Score (RS) has been validated in patients with ER + /HER2 - invasive breast carcinoma to estimate patient risk of recurrence and guide the use of adjuvant chemotherapy. We inves...

关键词： Artificial intelligence | Breast cancer | Oncotype DX | Machine learning | Magnetic resonance imaging | ONCOTYPE DX | CLINICAL-USE | BIOMARKERS | REGRESSION | DECISIONS...

3. Substituted Naphthalenedimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Vo, Tam | Oxenford, Sally ... - 《ACS medicinal chemistry letters》 - 2020,11(5) - 991～999 - 共9页 - 被引量：21

摘要：Interactions are reported of three representative naphthalene-diimide derivatives with three quadruplex targets, from the promoter region of the telomerase (hTERT) gene, a human telomeric DNA quadrupl...

关键词： Quadruplex | naphthalene diimides | surface plasmon resonance | fluorescence | modeling

4. Fragment-based approaches to TB drugs SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Marchetti, Chiara | Chan, Daniel S. H.... - 《Parasitology》 - 2018,145(2) - 184～195 - 共12页 - 被引量：14

摘要：Tuberculosis is an infectious disease associated with significant mortality and morbidity worldwide, particularly in developing countries. The rise of antibiotic resistance in Mycobacterium tuberculos...

关键词： tuberculosis | fragment-based approaches | medicinal chemistry | cytochrome P450 | pantothenate synthetase | EthR | BioA

5. Novel polyamine-based Histone deacetylases-Lysine demethylase 1 dual binding inhibitors NSTL国家科技图书文献中心

Milelli, Andrea | Marchetti, Chiara ... - 《Bioorganic and Medicinal Chemistry Letters》 - 2018,28(6) - 1001～1004 - 共4页 - 被引量：19

摘要：Epigenetic modulators Histone deacetylases (HDACs) and Lysine demethylase (LSD1) are validated targets for anticancer therapy. Both HDAC1/2 and LSD1 are found in association with the repressor protein...

关键词： Dual-binding agents | Epigenetics | tone deacetylase inhibitors | Lysine demethylase inhibitors | Polyamines

6. Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Milelli, Andrea | Marchetti, Chiara ... - 《European Journal of Medicinal Chemistry: Chimie Therapeutique》 - 2017,128 - 107～122 - 共16页 - 被引量：14

摘要：Naphthalene diimides (NDIs) have been widely used as scaffold to design DNA-directed agents able to target peculiar DNA secondary arrangements endowed with relevant biochemical roles. Recently, we hav...

关键词： Naphthalene diimides | Drug design | DNA | G-quadruplex | Telomeric DNA | Topoisomerase | Antiproliferative

7. Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Tarozzi, Andrea | Marchetti, Chiara ... - 《European Journal of Medicinal Chemistry: Chimie Therapeutique》 - 2016,117 - 283～291 - 共9页 - 被引量：12

摘要：Epidermal growth factor receptor inhibitors (EGFR-TKIs) represent a class of compounds widely used in anticancer therapy. An increasing number of studies reports on combination therapies in which the ...

关键词： EGFR-TK inhibitors | Multitarget agents | Sulforaphane | Isothiocyanate | Akt phosphorylation

8. Late Isometric Assessment of Hip Abductor Muscle and Its Relationship with Functional Tests in Elderly Women Undergoing Replacement of Unilateral Hip Joint SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Melchiorri, Giovanni | Viero, Valerio ... - 《American Journal of Physical Medicine and Rehabilitation》 - 2015,94(10) - 758～767 - 共10页 - 被引量：3

摘要：Objective The aim of this study was to evaluate the recovery of muscle strength and measure autonomy 3 yrs after hip replacement surgery in a sample of patients.

关键词： Hip Arthroplasty | Muscular Strength | Hip Rehabilitation | Strength Curve

9. Macrocyclic naphthalene diimides as G-quadruplex binders SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Marchetti, Chiara | Minarini, Anna ... - 《Bioorganic and medicinal chemistry》 - 2015,23(13) - 3819～3830 - 共12页 - 被引量：28

摘要：The synthesis, biological and molecular modeling evaluation of a series of macrocyclic naphthalene diimides is reported. The present investigation expands on the study of structure-activity relationsh...

关键词： G-quadruplex | Naphthalene diimide | Telomeric DNA | c-KIT | Docking

10. Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Zuccari, Guendalina | Milelli, Andrea ... - 《Journal of Controlled Release: Official Journal of the Controlled Release Society》 - 2015,211 - 44～52 - 共9页 - 被引量：35

摘要：Neuroblastoma is a childhood cancer with poor long-term prognosis in advanced stages. A major aim in neuroblastoma therapy is to develop targeted drug delivery systems to ameliorate drug therapeutic i...